Yung-Hun Yang's research while affiliated with Konkuk University and other places
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Publications (316)
Petrochemical-based plastics are hardly biodegradable and a major cause of environmental pollution, and polyhydroxybutyrate (PHB) is attracting attention as an alternative due to its similar properties. However, the cost of PHB production is high and is considered the greatest challenge for its industrialization. Here, crude glycerol was used as a...
Biomass gasification produces syngas, mainly comprised of CO and H2 along with H2S, CO2, N2, and tar compounds. Inorganic carbon present in syngas as CO and CO2 can be utilized for the production of several value-added chemicals including ethanol, higher alcohols, fuels, and hydrogen. However, chemical sequestration operates at a high temperature o...
Identification of novel, electricity-producing bacteria has garnered remarkable interest because of the various applications of electricigens in microbial fuel cell and bioelectrochemical systems. Shewanella marisflavi BBL25, an electricity-generating microorganism, uses various carbon sources and shows broader sugar utilization than the better-kno...
Indigo dye is an organic compound with a distinctive blue color. Most of the indigo currently used in industry is produced via chemical synthesis, which generates a large amount of wastewater. Therefore, several studies have recently been conducted to find ways to produce indigo eco-friendly using microorganisms. Here, we produced indigo using reco...
Coffee waste is an abundant biomass that can be converted into high value chemical products, and is used in various renewable biological processes. In this study, oil was extracted from spent coffee grounds (SCGs) and used for polyhydroxyalkanoate (PHA) production through Pseudomonas resinovorans. The oil–extracted SCGs (OESCGs) were hydrolyzed and...
Dyes are coloring agents widely used in the textile and leather industries. Synthetic dyes are the major contributor to global wastewater exhibiting toxic effects on humans, aquatic organisms, and the environment. The conventional decolorization treatments are less effective due to high dye concentration in wastewater, complex chemical structure, a...
In this study, fourteen types of biochar produced using seven biomasses at temperatures 300 °C and 600 °C were screened for phenolics (furfural and hydroxymethylfurfural (HMF)) removal. Eucheuma spinosum biochar (EB-BC 600) showed higher adsorption capacity to furfural (258.94±3.2 mg/g) and HMF (222.81±2.3 mg/g). Adsorption kinetics and isotherm ex...
Polyhydroxybutyrate (PHB) is a biodegradable bioplastic with potential applications as an alternative to petroleum-based plastics. However, efficient PHB production remains difficult. The main cost of PHB production is attributed to carbon sources; hence, finding inexpensive sources is important. Galactose is a possible substrate for polyhydroxyalk...
Methicillin-resistant Staphylococcus aureus (MRSA), one of the most well-known human pathogens, houses many virulence factors and regulatory proteins that confer resistance to diverse antibiotics. Although they have been investigated intensively, the correlations among virulence factors, regulatory proteins and antibiotic resistance are still elusi...
Polyhydroxyalkanoates (PHAs) are regarded as alternatives to petroleum-based plastics and can be produced through marine bacteria that have adapted to high-salt and low-temperature conditions. In this study, Halomonas sp. YLGW01 was used to produce PHAs using volatile fatty acids as carbon sources, and its utilization ability and optimization were...
Hydrogen has gained attention as an alternative source of energy because of its non-polluting nature as on combustion it produces only water. Biological methods are eco-friendly and have benefits in waste management and hydrogen production simultaneously. The use of algal biomass as feedstock in dark fermentation is advantageous because of its low...
Phasin is a surface-binding protein of polyhydroxyalkanoate (PHA) granules that is encoded by the phaP gene. As its expression increases, PHA granules become smaller, to increase their surface area, and are densely packed inside the cell, thereby increasing the PHA content. A wide range of PHA-producing bacteria have phaP genes; however, their PHA...
Antibiotics are powerful and reliable substances that can control microorganism growth. However, microbes employ several countermeasures to adapt to external stresses such as extreme salt concentrations and antibiotics. Among them, microbes can regulate the fatty acid composition of their cell membrane. Our previous study reported that Halomonas so...
Linifanib is known as an inhibitor of receptor tyrosine kinase. Even though it has been widely recognized as efficient inhibitor of receptor tyrosine kinases, anti-carcinogenic effect has not been investigated enough in ovarian cancer. In this study, we investigated the anti-cancer effect of linifanib on human ovary cancer SKOV3 cells. WST-1, cell...
Polybutylene succinate (PBS) is a bioplastic substitute for synthetic plastics that are made from petroleum-based products such as polyethylene and polypropylene. However, the biodegradation rate of PBS is still low and similar to that of polylactic acid (PLA). Moreover, our knowledge about degrader species is limited to a few fungi and mixed conso...
Using lignocellulosic biomass is immensely beneficial for the economical production of biochemicals. However, utilizing mixed sugars from lignocellulosic biomass is challenging because of bacterial preference for specific sugar such as glucose. Although previous studies have attempted to overcome this challenge, no studies have been reported on iso...
Polyhydroxybutyrate (PHB) is a bio-based, biodegradable and biocompatible plastic that has the potential to replace petroleum-based plastics. Lignocellulosic biomass is a promising feedstock for industrial fermentation to produce bioproducts such as polyhydroxybutyrate (PHB). However, the pretreatment processes of lignocellulosic biomass lead to th...
With increasing interest in biohydrogen as an alternative fuel to petroleum, it is essential to identify a hyper biohydrogen producer. In the present study, Clostridium sp. YD09 was isolated from a brewery wastewater upflow anaerobic sludge blanket digestion reactor; its 16 S ribosomal RNA sequencing analysis showed 96% similarity to Clostridium be...
Clostridioides difficile is a gram-positive anaerobic bacterium that causes antibiotic-associated infections in the gut. C. difficile infection develops in the intestine of a host with an imbalance of the intestinal microbiota and, in severe cases, can lead to toxic megacolon, intestinal perforation, and even death. Despite its severity and importa...
As a biodegradable plastic, polyhydroxybutyrate (PHB) has relatively poor mechanical properties, preventing its wider use. Various plasticizers have been studied to improve the mechanical properties of PHB; however, due to the slow degradation speed in the soil environment and lack of evaluation methods, studies on the degradation of PHB with plast...
Sphingobium yanoikuyae BBL01 can produce exopolysaccharides (EPS) and polyhydroxyalkanoates (PHAs). The effect of side products (furfural, hydroxymethylfurfural (HMF), vanillin, and acetate) produced during pretreatment of biomass was evaluated on S. yanoikuyae BBL01. It was observed that a certain concentration range (0.01-0.03%) of these compound...
The increasing interest in bioplastics, with regard to future environmental issues, has rendered research on bioplastic biodegradation highly important. However, only a few tools directly monitor the degradation of bioplastics without measuring the levels of gaseous products, such as carbon dioxide. Classical nonquantitative methods, such as clear...
Bacteria can evade antibiotics by acquiring resistance genes, as well as switching to a non-growing dormant state without accompanying genetic modification. Bacteria in this quiescent state are called persisters, and this non-inheritable ability to withstand multiple antibiotics is referred to as antibiotic tolerance. Although all bacteria are cons...
6‐Bromoindirubin (6BrIR), found in Murex sea snails, is a precursor of indirubin‐derivatives anticancer drugs. However, its synthesis remains limited due to uncharacterized biosynthetic pathways and difficulties in site‐specific bromination and oxidation at indole ring. Here, we present an efficient 6BrIR production strategy in E. coli by using fou...
Polyhydroxyalkanoate (PHA) is a biodegradable plastic that can be used to replace petroleum-based plastic. In addition, as a medium-chain-length PHA (mcl-PHA), it can be used to provide elastomeric properties in specific applications. Because of these characteristics, recently, there has been much research on mcl-PHA production using inexpensive bi...
The present study deals with the utilization of lignocellulosic hydrolysate-based carbon source for exopolysaccharide (EPS) production using newly reported marine Echinicola sediminis BBL-M-12. This bacterium produced 7.56 g L–1 and 5.32 g L–1 of EPS on supplementing 30 g L–1 glucose and 10 g L–1 xylose as the sole carbon source, respectively. Wher...
Continuous urbanization and modernization have increased the burning of fossil fuels to meet energy needs across the globe, emanating environmental pollution and depleting fossil fuels. Therefore, a shift towards sustainable and renewable energy is necessary. Several techniques to exploit biomass to yield energy are trending, with pyrolysis one of...
Urbanization and pollution are the major issues of the current time own to the exhaustive consumption of fossil fuels which have a detrimental effect on the nation's economies and air quality due to greenhouse gas (GHG) emissions and shortage of energy reserves. Algae, an autotrophic organism provides a green substitute for energy as well as commer...
Biohydrogen is a clean and efficient source of energy produced easily by anaerobic systems. Therefore, the discovery of novel and efficient production methods and utilization of inexpensive starting material are crucial for economical biohydrogen production. In this study, novel hydrogen producing bacterial strain Clostridium sp. SH25 was screened...
Anammox is a novel and autotrophic anaerobic ammonium oxidation process distinguished from the conventional biological nitrogen removal system. Unique features of this process are low biomass yield, airing free, and do not require external carbon addition, that makes anammox more promising and significant. Phylum Planctomycetes and its six genera c...
Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that causes severe diseases in humans. For decades, MRSA has acquired substantial resistance against conventional antibiotics through regulatory adaptation, thereby posing a challenge for treating MRSA infection. One of the emerging strategies to combat MRSA is the combina...
Staphylococcus aureus is a major human bacterial pathogen that carries a large number of virulence factors. Many virulence factors of S. aureus are regulated by the accessory gene regulator (agr) quorum-sensing system. Phenol-soluble modulins (PSMs) are one of the agr-mediated virulence determinants known to play a significant role in S. aureus pat...
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections and poses a global healthcare challenge. The utilization of novel molecules which confer synergistical effects to existing MRSA-directed antibiotics is one of the well-accepted strategies in lieu of de novo development of new antibiotics. Thymol is a key component of the es...
The one-carbon recursive ketoacid elongation pathway is responsible for making various branched-chain amino acids, aldehydes, alcohols, and acetate esters in living cells. Controlling selective microbial biosynthesis of these target molecules at high efficiency is challenging due to enzyme promiscuity, regulation, and metabolic burden. In this stud...
Background
Remdesivir is an anti-viral drug that inhibits RNA polymerase. In 2020, remdesivir was recognized as the most promising therapeutic agents against coronavirus disease 2019 (COVID-19). However, the effects of remdesivir on cancers have hardly been studied.
Purpose
Here, we reported that the anti-carcinogenic effect of remdesivir on SKOV3...
In the bioproduction of glutaric acid, an emerging bioplastic monomer, α-ketoglutaric acid (α-KG) is required as an amine acceptor for 4-aminobutyrate aminotransferase (GabT)-driven conversion of 5-aminovalerate (5-AVA) to glutarate semialdehyde. Herein, instead of using expensive α-KG, an indirect α-KG supply system was developed using a relativel...
![Annual production of Cannabis in Canada [36, 37]](publication/359256956/figure/fig4/AS:1135538639765506@1647744917150/Annual-production-of-Cannabis-in-Canada-36-37_Q320.jpg)
The global cannabis (Cannabis sativa) market was 17.7 billion in 2019 and is expected to reach up to 40.6 billion by 2024. Canada is the 2nd nation to legalize cannabis with a massive sale of $246.9 million in the year 2021. Waste cannabis biomass is managed using disposal strategies (i.e., incineration, aerobic/anaerobic digestion, composting, and...
The one-carbon recursive ketoacid elongation pathway is responsible for making various branched-chain amino acids, aldehydes, alcohols, and acetate esters in living cells. Controlling selective microbial biosynthesis of these target molecules at high efficiency is challenging due to enzyme promiscuity, regulation, and metabolic burden. In this stud...
Poly(butylene adipate-co-terephthalate) (PBAT), a bioplastic consisting of aliphatic hydrocarbons and aromatic hydrocarbons, was developed to overcome the shortcomings of aliphatic and aromatic polyesters. Many studies report the use of PBAT as a blending material for improving properties of other bioplastics. However, there are few studies on micr...
Acetylshikonin is a shikonin derivative originated from Lithospermum erythrorhizon roots that exhibits various biological activities, including granulation tissue formation, promotion of inflammatory effects, and inhibition of angiogenesis. The anticancer effect of acetylshikonin was also investigated in several cancer cells; however, the effect ag...
Excessive generation of wastewater is a matter of concern around the globe. Wastewater treatment utilizing a microalgae-mediated process is considered an eco-friendly and sustainable method of wastewater treatment. However, low biomass productivity, costly harvesting process, and energy extensive cultivation process are the major bottleneck. The us...
Polyhydroxybutyrate (PHB) is a potential substitute for plastics derived from fossil fuels, owing to its biodegradable and biocompatible properties. Lignocellulosic biomass could be used to reduce PHB production costs; however, the co-utilization of sugars, such as glucose and xylose, without catabolite repression is a difficult problem to be solve...
Background:
Gallbladder cancer is commonly associated with inflammation, which indicates that inflammation-related cytokines and cytokine receptors are related to the progression of gallbladder cancers. Interleukin 4 (IL4) is a well-known cytokine that promotes the differentiation of naive helper T cells (Th0) to T helper type 2 cells (Th2). IL13...
The existing study deals with adsorptive removal of the endocrine-disrupting chemical bisphenol-A and toxic azo dye solvent black-3 from single and binary solutions. These two contaminants are commonly used as an additive in the synthetic plastic industries. Among the tested twenty pristine and modified biochars, the pristine pinecone biochar produ...
In this study, to engineer a polyhydroxybutyrate (PHB) biopolymer, pyomelanin pigment was coproduced in a single Escherichia coli host and incorporated into PHB. The cells convert l-tyrosine into pyomelanin via the formation of homogentisate by expressing hydroxyphenylpyruvate dioxygenase (hppd), while producing PHB by expressing bktB, phaB, and ph...
The hydrogen (H2) economy has been recognized globally from a socio-economic, and environmental viewpoint. Hydrogen can be produced using technologies such as electrolysis, thermochemical, photoelectrochemical, and biological methods. Biological methods help in waste management and energy production simultaneously. To make the biohydrogen process e...
Faecalibacterium prausnitzii , a major commensal bacterium in the human gut, is well known for its anti-inflammatory effects, which improve host intestinal health. Although several studies have reported that inulin, a well-known prebiotic, increases the abundance of F. prausnitzii in the intestine, the mechanism underlying this effect remains uncle...
Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid act as a major neurotransmitter inhibitor in the nervous system of mammals. It also used as a precursor of bioplastics synthesis such as N-methylpyrolidone and polyamide 4. Chemical-based synthesis methods have many environmental-related issues, so efforts have been made to develop bi...
Quantum dots (QDs) are getting special attention due to their commendable optical properties and applications. Conventional metal-based QDs have toxicity and non-biodegradability issues, thus it becomes necessary to search for renewable precursor molecules for QDs synthesis. In recent years, biomass-based carbon rich QDs (CQDs) have been introduced...
Polyhydroxyalkanoates (PHAs) and their derivatives are biopolymers that have the potential of replacing petroleum-based plastics and can be produced and degraded via bacterial metabolism. However, there are only a few
studies on polyhydroxybutyrate (PHB) production using lactate, one of the major waste organic acids that could
be implemented in the...
Having the advantage of eco-friendly decomposition, bioplastics could be used to replace petroleum-based plastics. In particular, poly(3-hydroxybutyrate) (PHB) is one of the most
commercialized bioplastics, however, necessitating the introduction of PHB-degrading bacteria for
its effective disposal. In this study, Microbulbifer sp. SOL66 (94.18% 16...
The cellular components of Akkermansia muciniphila are considered potential biotherapeutics for the improvement of obesity, diabetes, and metabolic diseases. However, the molecular-based mechanism of A. muciniphila for treatment of obesity, which can provide important evidence for human research, has rarely been explored. Here, we applied integrati...
The efficiency of anaerobic digestion could be increased by promoting microbial retention through biofilm development. The inclusion of certain types of biofilm carriers has differentiated existing AD biofilm reactors through their respective mode of biofilm growth. Bacteria and archaea engaged in methanogenesis during anaerobic processes potential...
Cellulosic ethanol production has received global attention to use as transportation fuels with gasoline blending virtue of carbon benefits and decarbonization. However, due to changing feedstock composition, natural resistance, and a lack of cost-effective pretreatment and downstream processing, contemporary cellulosic ethanol biorefineries are fa...
Broussochalcone A (BCA) is a chalcone compound extracted from the cortex of Broussonetiapapyrifera (L.) Ventenat that exerts various effects, such as potent antioxidant, antiplatelet, and anticancer effects. However, the effects of BCA against cancers have been seldom studied. This study is aimed at demonstrating the apoptotic mechanisms of BCA in...
Ever since bioplastics were introduced to a wide range of industries globally, disposal of the used bioplastics has become an inseparable issue with their application. Unlike petroleum-based plastics, bioplastics can be completely decomposed into water and carbon dioxide by microorganisms in a relatively short time, which is an advantage. However,...
L-pipecolic acid (L-PA) is a key chiral intermediate in the synthesis of many important drugs. However, there is a lack of research on the efficient extraction and purification process for L-PA. Here, eleven different organic solvents were evaluated for selective extraction of L-PA by physical extraction. Among these solvents, methyl ethyl ketone (...
Petroleum-based plastic is a widely used commodity in modern living due to its extensive industrial and domestic applications. Polyethylene and polypropylene account for more than 50% of total plastic usage, and they resist decomposition in a natural environment. In this study, Lysinibacillus sp., isolated and identified as a novel strain, was inve...
Clostridium acetobutylicum is an attractive industrial microorganism for biochemical production, but there have been few attempts for bio-hydrogen production based on metabolic engineering. In this study, metabolically engineered C. acetobutylicum carrying glucose-6-phosphate dehydrogenase (zwf) and FeFe hydrogenase (hydA) were constructed as recom...
Phasin (PhaP), one of the polyhydroxyalkanoate granule-associated protein, enhances cell growth and polyhydroxybutyrate (PHB) biosynthesis by regulating the number and size of PHB granules. However, few studies have applied phasins to various PHB production conditions. In this study, we identified novel phasin genes from the genomic data of Arctic...
Carbon constraints, as well as the growing hazard of greenhouse gas emissions, have
accelerated research into all possible renewable energy and fuel sources. Microbial electrolysis cells (MECs), a novel technology able to convert soluble organic matter into energy such as hydrogen gas, represent the most recent breakthrough. While research into ene...
![Various microbial metabolic products and their uses [28,55,63].](profile/Piyush-Gupta-66/publication/353638190/figure/tbl1/AS:1052314383155201@1627902708543/Various-microbial-metabolic-products-and-their-uses-28-55-63_Q320.jpg)
Crude oil is a major energy source that is exploited globally to achieve economic growth.
To meet the growing demands for oil, in an environment of stringent environmental regulations and economic and technical pressure, industries have been required to develop novel oil salvaging techniques. The remaining ~70% of the world’s conventional oil (one-...
The present study was aimed to investigate brilliant green (BG) dye sorption onto soybean straw biochar (SSB) prepared at 800⁰C and further understanding the sorption mechanism. Sorption kinetic models such as pseudo-first and second order were executed for demonstrating sorption mechanism between the dye and biochar. Results of kinetics study were...
In this study, a newly isolated halotolerant strain Oceanisphaera arctica YHY1, capable of hydrolyzing seafood processing waste chitin biomass, is reported. Microbial fuel cells fed with 1% chitin and 40 g L−1 as the optimum salt concentration demonstrated stable electricity generation until 216 h (0.228 mA/cm2). N-acetyl-D-glucosamine (GlcNAc) was...
Tremendous population growth and industrialization have increased energy consumption unprecedentedly. The depletion of fossil-based energy supplies necessitates the exploration of solar, geothermal, wind, hydrogen, biodiesel, etc. as a clean and renewable energy source. Most of these energy sources are intermittent, while bioelectricity, biodiesel,...
The present investigation deals with production of biochar using various agricultural and non-agricultural waste biomass followed by sorption of methylene blue (MB) dye. The optimization of pyrolysis temperature, dye solution pH, incubation temperature, and time was performed using response surface methodologies (RSM). Analytical tools like Fourier...
Community-associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) is notorious as a leading cause of soft tissue infections. Despite several studies on the Agr regulator, the mechanisms of action of Agr on the virulence factors in different strains are still unknown. To reveal the role of Agr in different CA-MRSA, we investigated the LACΔa...
Polyhydroxyalkanoates (PHAs) are bioplastic substitutes for petroleum-derived plastics that may help to reduce the increasing environmental impact of plastic pollution. Among them, polyhydroxybutyrate (PHB) is a promising biopolymer, incentivizing many researchers to search for PHB-producing and PHB-degrading bacteria for improved PHB utilization....
Biodiesel is an environmentally friendly, biodegradable, and renewable source of energy. It can be used as an alternate source of energy to reduce overburden on fossil-based fuels. The use of waste cooking oil (WCO) for biodiesel production may solve its management problem and provide additional revenue. Rhodococcus is an oleaginous microbe that ca...