Yun Zhu's research while affiliated with Fudan University and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (8)
Objective:
Mask positive pressure ventilation could lead to inhomogeneity of lung ventilation, potentially inducing lung function impairments, when compared with spontaneous breathing. The inhomogeneity of lung ventilation can be monitored by chest electrical impedance tomography (EIT), which could increase our understanding of mask ventilation-de...
Background:
The systemic inflammatory has been suggested to predict the prognosis of cancer patients. There are two kinds of methods for evaluating the systemic inflammatory response, namely, composite ratios and cumulative scores. The aim of our study was to compare the prognostic effect of scores and ratios in patients undergoing surgery for liv...
Objective
An acute severe stress response associated with major surgery can adversely affect the inflammatory and hormonal responses. We hypothesised that total intravenous anaesthesia (TIVA) combined with thoracic epidural anaesthesia and analgesia (TEA) attenuates the stress response and postoperative pain in patients undergoing radical oesophage...
This study aimed to investigate the protective effects of oridonin (ORI) on cecal ligation and puncture (CLP)-induced sepsis in mice. Male C57BL/6 mice weighing 22–30 g and aged 8–10 weeks were randomly assigned to three groups: Sham group, CLP group, or CLP plus ORI group. In the CLP group and ORI group, CLP was induced, and intraperitoneal inject...
Perioperative hyperglycemia is a common clinical metabolic disorder. Hyperglycemia could induce endothelial apoptosis, dysfunction and inflammation, resulting in endothelial injury. Propofol is a widely used anesthetic drug in clinical settings. Our previous studies indicated that propofol attenuated high glucose-induced endothelial apoptosis, dysf...
Volatile anesthetics modulate endothelial cell apoptosis and inhibit nuclear factor-κB (NF-κB) signaling. In this study, we aimed to assess whether desflurane preconditioning protects human umbilical vein endothelial cells (HUVECs) agaist anoxia/reoxygenation (A/R) injury. HUVECs were pre-conditioned with desflurane (1.0 MAC) for 30 min, followed b...
The activation of renin angiotensin system is involved in multiple pathological processes. The neuroprotective effect of propofol has been reported. We hypothesized that propofol may attenuate Ang II-induced apoptosis in mouse hippocampal HT22cells and aimed to identify the underlying mechanisms.
Mouse hippocampal HT22cells were pre-treated with pr...
Fentanyl-induced cough (FIC) should be effectively prevented in patients requiring stable induction of general anesthesia. Our study was to evaluate the suppressive effects of different doses of intravenous dezocine on FIC during the induction of general anesthesia. A total of 400 patients of American Society of Anesthesiologists (ASA) physical sta...
Citations
... By reading 30 full-text articles, 3 articles with duplicate data and four articles that could not provide effect size were eliminated. Ultimately, 23 studies 9-11 [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] were included in the meta-analysis (figure 1). The basic characteristics of 23 studies are presented in table 1. ...
... In support of the ameliorative role of EA, serum cytokines' levels were significantly increased at 24-hr after surgery than in preoperative and immediately PO samples. Similarly, previous two studies found the combination of EA and TIVA [33] or GA [34] significantly attenuated the intraoperative stress response and serum cytokines' levels. Also, a previous comparative study between remifentanil and EA during one-lung ventilation anesthesia detected higher cytokines' concentrations with remifentanil than with [35]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1159992786845697-1653575240423_Q64/Jing-Zhong-22.jpg)
... Besides its anticancer activity, oridonin possesses an extensive range of biological activities, such as anti-inflammatory (Cummins et al., 2019), neuroprotective (Lin et al., 2019), anti-microbial , anti-fibrotic (Bohanon et al., 2014), anti-sepsis (Zhao et al., 2016), immune-modulating (Guo et al., 2013), and analgesic effects (Zang et al., 2016). A search of the PubMed.gov ...
... Inhibition of NF-B can reduce the production of chemotactic factors in endothelial, epithelial, and resident macrophages in mouse lung [33,34]. Therefore, we speculated that desflurane may influence the production of proinflammatory cytokines through an NF-B-mediated pathway [35,36]. In the current study, the levels of NF-B protein were significantly increased after lipopolysaccharide administration and mechanical ventilation but significantly decreased by desflurane. ...
... Furthermore, the treadmill exercise could restore the dendritic complexity ( Figure S1, Repeated two-way ANOVA, radius factor x treat factor, F = 2.855, df 50/300, p < 0.0001). Since a previous study showed that Ang II could lead to mouse hippocampal neuronal cell apoptosis [34], we intend to study whether treadmill exercise could preserve the neuron cell under 2K1C-induced hypertension. As previously described, we evaluated the pyknotic neuronal cell numbers from CA1 and the dentate gyrus (DG) by H&E staining [35]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/278591549001743-1443432809608_Q64/Changhong-Miao-3.jpg)
... Additionally, dezocine possesses norepinephrine uptake inhibitory activity, which could synergize with mu agonists in the case of acute pain treatment and possibly endow the drug with good pain relief in neuropathic pain conditions [33]. Previously, we and others found that that the use of dezocine during the induction of anesthesia suppressed the occurrence of sufentanyl-induced coughing, including RCTs [34][35][36] and meta-analyses [37,38]. For these reasons, owing to the preference of anesthesiologists, in our practice, some patients received approximately 0.1-0.15 ...
