October 2021
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9 Reads
Placenta
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October 2021
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9 Reads
Placenta
November 2019
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9 Reads
Placenta
November 2018
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10 Reads
Journal of Reproductive Immunology
May 2018
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14 Reads
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3 Citations
Gan to kagaku ryoho. Cancer & chemotherapy
A 33-year-old woman became aware of a right breast mass at her 28th week of pregnancy. From the biopsy results, we diagnosed her with right breast cancer. At her 33rd week of pregnancy, she underwent modified radical mastectomy (pT2N3aM0, Stage III C, ER-negative, PR-negative, HER2-positive), and she elected to receive adjuvant therapy after the surgery during her pregnancy. She received the first course of EC (epirubicin plus cyclophosphamide) therapy on the 13th postoperative day (35 weeks of gestation) and gave a natural, vaginal delivery at 36 weeks and 5 days of gestation. On the 4th day after birth, the patient noticed a contralateral left breast mass and was diagnosed with left breast cancer, after core needle biopsy. She received 4 courses of EC therapy and is currently undergoing PTX plus HER (paclitaxel plus trastuzumab) therapy. Regarding chemotherapy during pregnancy, we recommend that there is no need to perform artificial preterm birth, because chemotherapy has little influence on children after their second-trimester. After the second-trimester, chemotherapy can be safely performed.
November 2017
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31 Reads
Journal of Reproductive Immunology
January 2017
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141 Reads
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10 Citations
Open Journal of Obstetrics and Gynecology
Aim: The aim of the present study was to examine associations among maternal stress level, general health, mother to infant bonding, maternal depression level, and mode of delivery. Methods: Mothers who delivered a single baby at term were recruited with a total 435 mothers participating in the study. Outcome measures: Data were collected 6 months after delivery using General Health Questionnaire (GHQ-28), Mother-to-Infant Bonding Scale (MIBS), Edinburgh Postnatal Depression Scale (EPDS) as well as socio-demographic and medical information at 6 months. Additionally, salivary cortisol and chromogranin levels were determined. Results: The proportion of breast-feeding mothers in the vaginal delivery group (51.4%) was significantly higher than that of the cesarean section group (24%). GHQ-28 scores were significantly related to EPDS scores and MIBS scores (P Conclusion: Maternal general health is associated with maternal psychological health. These results suggest that the support of maternal health is important to maintain maternal psychological status and bonding to infants. Because EPDS scores were significantly worse in the planned cesarean section group (4.2 ± 3.3), careful management is needed of mothers who deliver by planned cesarean section.
December 2014
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623 Reads
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20 Citations
Sexual Medicine
IntroductionFemale sexual function changes considerably during pregnancy and the postpartum period. In addition, women's physical and mental health, endocrine secretion, and internal and external genitalia vary during these times. However, there are limited studies on the relationship between delivery and sexual function.AimThe present study aimed to demonstrate the association between sexual function and delivery mode.Methods Mothers who delivered a single baby at term were recruited for the study, and 435 mothers were analyzed.Main Outcome MeasuresThe Female Sexual Function Questionnaire (SFQ28) scores and mothers' backgrounds were assessed at 6 months after delivery.ResultsThe delivery mode affected the SFQ28 partner domain. Episiotomy affected the arousal (sensation) domain. Multiple regression analysis revealed that maternal age and cesarean section were significantly associated with several SHQ28 domains.Conclusion This study suggests that routine episiotomies at delivery should be avoided to improve postpartum maternal sexual function. Maternal age and cesarean section were found to affect postpartum sexual health. Song M, Ishii H, Toda M, Tomimatsu T, Katsuyama H, Nakamura T, Nakai Y, and Shimoya K. Association between sexual health and delivery mode. Sex Med **;**:**–**.
October 2014
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32 Reads
Placenta
May 2014
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190 Reads
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3 Citations
Oncology Reports
Cisplatin-based concurrent chemoradiotherapy (CCRT) has become a standard treatment for cancer of the uterine cervix. However, there have been no investigations into the optimum timing for administration of anticancer drugs using animal models. The aim of the present study was to determine the appropriate timing for administration of the anticancer drug cisplatin in relation to delivery of radiation by assessing the antitumor activity and adverse effects of 3 different regimens in αT3 transgenic mice bearing lens epithelial tumors. CCRT showed the strongest antitumor activity. There was a significant difference between CCRT and administration of cisplatin before radiotherapy (neoadjuvant therapy) with regard to the apoptotic effect detected by TUNEL staining, but there was no significant difference between CCRT and administration of cisplatin after radiotherapy (adjuvant therapy). Assessment of adverse effects showed that there were no significant differences in the mortality rate, weight loss, anemia and leukopenia among the 3 regimens. In conclusion, these findings obtained in an animal model suggest that cisplatin should probably not be administered before irradiation, since the antitumor effect is significantly weaker than that of CCRT or administration after irradiation, while adverse effects are similar.
October 2012
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68 Reads
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2 Citations
International Cancer Conference Journal
Because the number of hemodialysis patients is increasing, chemotherapy will need to be performed on more of these patients in the future. Carboplatin is metabolized by the kidneys and excreted in the urine, so delayed excretion caused by renal dysfunction can lead to severe adverse effects. Here, we report on the successful and safe performance of chemotherapy in a hemodialysis patient with stage IV ovarian cancer, based on alteration of the dialysis time and pharmacokinetic monitoring. A 60-year-old woman on hemodialysis for chronic renal failure was referred to our hospital with a left ovarian tumor and multiple metastases. After surgery, she received adjuvant chemotherapy with paclitaxel and carboplatin on a weekly basis. Initially, hemodialysis was done the next morning (16 h after chemotherapy), and grade 3 neutropenia occurred on day 8 of her first course. Pharmacokinetic analysis revealed the persistence of a high total blood platinum concentration until the start of hemodialysis. Therefore, hemodialysis was performed only 2 h after the second course of chemotherapy. At that time, the total platinum concentration had decreased to the range found in patients with normal renal function, and adverse effects were mild. For the third to sixth courses, chemotherapy was performed safely on an outpatient basis. Her multiple metastases were eliminated by chemotherapy. At 14 months after surgery, there is no evidence of recurrence.
... Two articles were reviews examining trastuzumab administration during pregnancy [11,13], while 31 articles were deemed irrelevant. There were 5 additional cases where the patient declined chemotherapy during pregnancy and thus treatment with trastuzumab was withhold until after delivery [14][15][16][17][18]. These articles were not eligible for our study. ...
May 2018
Gan to kagaku ryoho. Cancer & chemotherapy
... ideas, and outright rejection of the child 19 . Numerous further studies provide evidence for an association between PPD and mother-child bonding disorders 14,[18][19][20]24,31 . A possibility to prevent adverse outcomes such as PPD and an impaired mother-child-bonding might be breastfeeding. ...
January 2017
Open Journal of Obstetrics and Gynecology
... There have been few cases of the PC chemotherapy in HD patients with ovarian cancer. [3][4][5][6][7][8][9][10][11][12] The dose and time interval between the administration of carboplatin and HD are difficult to determine. This study presents the course of treatment for a HD patient with ovarian cancer. ...
October 2012
International Cancer Conference Journal
... Clinical trial [21][22][23] Cross-sectional study [18,[24][25][26][27][28][29][30][31][32][33][34][35][36][37] Prospective cohort study [20,[38][39][40][41][42][43][44][45][46][47][48][49] Iranian version of 19-item FSFI [18,[50][51][52] Hungarian version of 19-item FSFI [35] Taiwan version of 19-item FSFI [44,53] The Turkish version of 19-item FSFI [46,54] German version of Female Sexual Function Index (FSFI-d) [38,55] SFQ28 [56] 2002 Sexual health Cross-sectional study [57] ----PISQ-12 [58] 2003 Sexual function in women with pelvic organ prolapse and/or urinary incontinence ...
December 2014
Sexual Medicine
... Each treatment group was made of five young mice of similar weight and age. They were treated with five doses of cisplatin (1, 2, 4, 6, and 8 mg/kg body wt) for 3 days by a continuous intraperitoneal treatment based on previous publication 37 and our standardization of procedure. After 3 days of CDDP treatment of transgenic mice, the liver tissue was dissected and the bone marrow cells were isolated for further experimentation. ...
May 2014
Oncology Reports
... ROS are also lipid-peroxidation-inducing agents and 4-HNE is formed during lipid peroxidation of 6-polyunsaturated fatty acids by superoxide. This α,β-unsaturated aldehyde is highly reactive with proteins and DNA and induces cyclooxygenase-2, which controls prostaglandin production during inflammation, and interferes with nuclear factor-kappa beta (NF-κB) signalling pathways, whose activation is associated with inflammation and oxidative stress [34][35][36]. Mitochondrial proteins are targets of 4-HNE adduct formation and may influence mitochondrial uncoupling, transport and pore functions [37][38][39]. ...
August 2011
Gynecologic and Obstetric Investigation
... Finally, at 12 months postpartum, Parry et al. (2003) found that lower cortisol was linked to depression. In contrast to these significant associations between cortisol and depression across the first year postpartum, null results were identified by a number of investigators (e.g., Cheng & Pickler 2010;Davis et al. 2007;Field & Diego 2008;Nazzari et al. 2020;Tsubouchi et al. 2011). ...
April 2011
Journal of Obstetrics and Gynaecology Research