Yu-Ming Fan's research while affiliated with Cardinal Tien Hospital and other places

Publications (29)

Article
Purpose Alzheimer disease (AD) is an irreversible neurodegenerative disease that causes progressive cognitive decline. Co-existing thymoma should be considered when rapid deterioration of cognition was noted in AD patients and removal of thymoma may improve cognition in AD. Case report We report a 72-year-old woman with initial complaints of memory...
Article
We present a 56-year-old woman with metastatic follicular thyroid cancer at the nose tip with I uptake that is clinically rare, mimicking physiological uptake in the nose, a common finding seen after routine I therapeutic imaging. The lesion revealed a metastatic follicular thyroid cancer with I uptake and response to I therapy. Surgical removal, h...
Article
Full-text available
Rationales: Restless leg syndrome (RLS) is a common complication in patients with end-stage renal disease (ESRD). However, there is a lack of biomarkers linking uremic RLS to dopaminergic neurons. Previous studies demonstrated that Tc-99m TRODAT-1 SPECT was a biomarker for RLS but the correlation between the physiologic parameter was lacking. Meth...
Article
Purpose: This study aimed to characterize changes in regional cerebral blood flow (rCBF) in patients who experienced carbon monoxide (CO) poisoning and subsequently developed severe delayed neuropsychiatric sequelae (DNS) with akinetic mutism. We determined whether these changes were reversible in parallel with improvements in neuropsychological f...
Article
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Sleep-related movement disorders (SRMD) are sleep disorders. As poor sleep quality is associated with cognitive impairment, we hypothesized that SRMD patients were exposed to a great risk for developing dementia. The present study was aimed to retrospectively examine the association of SRMD and dementia risk. A retrospective longitudinal study was...
Article
Restless legs syndrome (RLS) is a neurological sensory motor disorder of which pathophysiology remains sketchy. The present study was aimed to determine the diagnostic accuracy and potential of SPECT-TRODAT imaging in discriminating patients with RLS from normal individuals. A total of 34 subjects, 22 diagnosed with RLS and 12 classified as normal,...
Article
Detection of regional cerebral blood flow (rCBF) and/or brain magnetic resonance imaging (MRI) has been used to investigate functional defect of brain caused by carbon monoxide (CO) poisoning. In this report, we attempted to demonstrate the correlation of changes in brain singlephoton emission computed tomography (SPECT) and diffusion-tensor MR ima...
Article
We propose a new method to help physicians assess, using a hepatobiliary iminodiacetic acid scan image, whether or not there is bile reflux into the stomach. The degree of bile reflux is an important index for clinical diagnosis of stomach diseases. The proposed method applies image-processing technology combined with a hydrodynamic model to determ...
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Purpose: Several reports have suggested that multilingualism has a protective effect against semantic dementia. Here, we provide further evidence for this effect. Case reports first: The patient was a 75-year-old right-handed Taiwanese woman who had retired after working as a tailor. She was able to speak Taiwanese, Japanese and Mandarin Chinese...
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This is a case report of hyperbaric oxygen therapy (HBO2T) for ischemic stroke. HBO2T should be the potential or additional treatment (with thrombolytic therapy) for ischemic stroke according to the preclinical and clinical studies. Hereby, we present a 56-year-old Chinese man with vascular risk factors. He had an acute ischemic stroke on the left...
Article
The pathophysiology of complex regional pain syndrome type 1 (CRPS 1) correlates with variances in both the peripheral and central nerve system. We attempted to explore the topographic correlation between changes in regional cerebral blood flow (rCBF) and 3-phase bone scans during treatments of a series of somatic nerve blocks. The case we present...
Article
Enterogastric reflux (EGR) is regarded as an unavoidable consequence of distal gastrectomy. We evaluated the efficacy of Roux-en-Y (RY) gastrojejunostomy and Braun enteroenterostomy (BEE) for preventing EGR. Between January 2002 and January 2005, 60 patients who underwent distal gastrectomy for gastric cancer or peptic ulcers were divided into RY,...
Article
Mediastinal lymphadenopathy is usually a sign of serious underlying disease. A patient who had nodular patchy opacity of the right hilum from a routine screening chest radiograph was referred for the whole-body PET/CT scan with FDG. The initial PET/CT scan demonstrated mediastinal lymphadenopathy and a 2-month follow-up PET/CT revealed the progress...
Article
A 60-year-old woman with prior right upper lobe lobectomy for adenocarcinoma of the lung was referred for a combined F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging to evaluate an enlarging right cervical node. The F-18 FDG PET/CT images showed a level III nodular lesion with increased FDG uptake in...
Article
When using F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) in the detection of various malignant tumors, those with normal or low metabolic activity may lead to false-negative results. In combination with computed tomography (CT) and anatomic concepts, we successfully identified a patient with renal cell carcinoma, which showed...
Article
Uterine leiomyoma may cause slightly or moderately increased F-18 fluorodeoxyglucose (F-18 FDG) uptake in the low pelvis. However, severely intense FDG accumulation resulting from the disease is rare. We present a patient with uterine leiomyoma and metastatic clear cell carcinoma from the ovary, whose F-18 FDG positron emission tomography/computed...
Article
Analyzing changes in regional cerebral blood flow (rCBF) with SPECT in complex regional pain syndrome type 1 (CRPS 1), formerly known as reflex sympathetic dystrophy, is an optimal method for evaluating effective pain relief. We attempted to investigate the correlation of changes in rCBF with pain relief during treatments of sympathetic blockade an...
Article
Malignant struma ovarii is a rare disease in gynecology and the optimal treatment regimen for the tumor remains obscure. We present a patient who bad malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases shown on posttreatment iodine I-131 single-photon emission tomography (SPECT) and low-dose computed tomograp...
Article
Full-text available
18 F- fluorodeoxyglucose positron emission tomography (FDG-PET) to evaluate the nature of the nodule. FDG- PET images showed downward displacement of both diaphragms with flattened upper boarder of the liver, elongated vertical dimension of the thoracic cavity, and increased radioactivity in the region of the stomach, while there was no definite le...
Article
A 4-year-old boy was hospitalized for anemia. Because he had dark stool after admission, technetium-99m pertechnetate scintigraphy was performed to screen for ectopic gastric mucosa. Incidental accumulation of Tc-99m pertechnetate in the transverse colon was noticed, and it was seen early and then faded, which indicated lesions with increased blood...
Article
Several clinical conditions, such as deep vein thrombosis, cerebral infarct, pulmonary infarct, skin ulcers, renal failure, and habitual abortion, are thought to be associated with the antiphospholipid syndrome. The authors describe a 32-year-old woman who had characteristics of the antiphospholipid syndrome including increased immunoglobulin G-car...
Article
Background: The purpose of this investigation was to study the effects of adrenergic stimulation on left ven- tricular systolic and diastolic functions in the patients with coronary artery disease (CAD) and following suc- cessful percutaneous transluminal coronary angioplasty (PTCA). Methods: Twelve normal subjects (M 8, F 4; aged 61 ± 7) and twent...
Article
201 Tl-thallous chloride ( 201 Tl) on myocar- dial scintigraphy. We reported such a case. The 38- year-old woman with a one-year-old lactating infant suf- fered from intermittent chest distress for several months. Electrocardiogram showed intermittent ventric- ular tachycardia. 201 Tl myocardial perfusion scintigraphy was performed and revealed nor...
Article
Full-text available
We present a case of Gorham's disease of the skull by using 99m Tc-MDP bone SPECT-CT to demonstrate simultaneously a large defect of the skull corresponding to the photon-deficient area in the left parietal skull. An important advantage of the combined SPECT-CT is that it can be acquired without moving the patient, and thus this imaging modality is...

Citations

... Anemia was associated with neuron function in patients with CKD. Our previous study demonstrated that hemoglobin concentration was negatively correlated with striatum function in patients with ESRD (Hou et al., 2020). Mazumder et al. (2019) reported that mitochondrial dysfunction and oxidative stress accumulation within the brain were the main molecular mechanisms involved in cognitive impairment in an adenine-induced CKD animal model. ...
... Language and verbal functioning are relatively resistant to the effects of neurotoxicant exposure. Although akinetic mutism has been reported in patients with carbon monoxide poisoning (Chen et al., 2016;Sakamoto et al., 1998) when present, performance deficits on tests of language and verbal function such as dysarthria and word finding problems (anomia) are often more likely to be consistent with cerebrovascular injury and AD respectively than with toxic encephalopathy . (Note: neuropsychological testing is explained in greater detail in a dedicated chapter.) ...
... 1 Evidence has grown over the past several years that sleep disturbances are a risk factor for dementia. 1,2,[5][6][7][8] For example, idiopathic rapid eye movement sleep behavior disorder often predicts the onset of neurodegenerative disease in 10-15 years. 1 Only five hours of sleep per night can increase dementia risk by 30% for adults 50 and older, 7 and sleep-related movement disorders, one of the classes of sleep disorders, increases the risk of all-cause dementia by 3.95 times for middle-aged and older adults. 6 It is likely that sleep deprivation and insomnia increase amyloid-β levels in plasma and the brain-a major clinical indicator of and pathological agent in Alzheimer's disease. ...
... [123I]N-ω-fluoropropyl-2βcarbomethoxy-3β-(4-iodophenyl)nortropane ( 123 I-FP-CIT), which is the most widely used radiotracer, while the latest radiotracer of this category 99m Tc-TRODAT-1 has been also accepted to be used in clinical settings [7]. The SBR in normal individuals, reported in studies with 123 I-FP-CIT, ranging from 1.9 to 5.5 [1,8,9], which was higher than the SBR value reported by studies using this radiotracer 99m Tc-TRODAT-1 (with values usually <1) [10,11]. Considering the lower value of SBR obtained by 99m Tc-TRODAT-1 SPECT, we decided to compare ordered subsets expectation-maximization (OSEM) with filtered back-projection (FBP) reconstruction in order to study the impact of different iteration and cut-off frequencies on SBR values amongst patients with different stages of DAT reduction upon visual assessment. ...
... Similarly, perfusion SPECT neuroimaging has proven useful in the evaluation of delayed neuropsychiatric sequalae of CO poisoning, as well in assessing response to treatments (301,314,315,(322)(323)(324)(325). Hypoperfusion of the basal ganglia have been correlated with the well-established finding of T2 hyperintensities in the globus pallidus by MRI (314,320,324). ...
... Computational simulations, which would account for the dynamic interaction between the choledynamics and wall deformation, are known as fluid-structure interaction (FSI) simulations, providing realistic results to obtain relevant choledynamic factors. Numerical and analytical CFD models applied to bile flow study have been proposed by several research groups Li et al. 2007;Li et al. 2008a;Maiti and Misra 2011;Agarwal et al. 2012a;Kuchumov et al. 2013aKuchumov et al. , 2014Lo et al. 2015;Agarwal and Singh 2016). Ooi et al. (2004) proposed two-dimensional and three-dimensional computational models of the bile flow in the cystic duct considered as a channel with baffles. ...
... Currently, the mechanisms of the negative effect of smoke components on the human and animal body when inhaled are well-known; however, their toxic effects are often evaluated independently of each other without taking into account the possible combined effect. Neurotoxic effects have been widely studied in acute severe CO poisoning and are characterized by impaired complex brain functions, such as perception, processing and analysis of information, memorization, and learning [32][33][34]. With prolonged exposure to low concentrations of CO, the impairment of the functional state of the nervous system does not correlate with the content of COHb in the blood and can also manifest itself some time after the end of contact [35,36]. ...
... In 1955 Gorham and Stout (8) stated that, "the progressive osteolysis is always associated with an angiomatosis of blood and sometimes by lymphatic vessels, which seemingly are responsible for it". Progressive bone resorption may occur spontaneously or following trauma and about 57% of patients point out trauma in their medical history (7,(9)(10)(11)(12)(13). The exact bone loss mechanism is not known yet. ...
... Furthermore, the first symptom of language decline was most commonly word retrieval impairment in L2 (Costa et al., 2019). Five case-studies measuring language decline longitudinally, but without any intervention, were included in the review papers (Druks & Weekes, 2013;Filley et al., 2006;Larner, 2012;Liu et al., 2012;Machado et al., 2010). In all five cases, L2 declined before or in parallel with L1, but as the disease progressed, both L1 and L2 were impaired in a similar manner. ...
... Studies have proposed a variety of mechanisms that allow for HBOT's positive effects, such as reducing inflammation and stabilizing the BBB. [43][44][45][46] These mechanisms are associated with the destruction of mitochondria which led the current study to research the role of mitochondria as a target of HBOT. [47,48] After stroke, the transfer of mitochondria was observed lining up with the research. ...