Yu-Cheng Lin’s research while affiliated with National Cheng Kung University and other places

Aim This study depicts the age trajectories of loneliness and gender differences among older adults in Taiwan and Japan. Methods Two nationally representative data sets for older adults in Taiwan and Japan were obtained from the Taiwan Longitudinal Study on Aging (TLSA, 1996–2011) and the National Survey of the Japanese Elderly (NSJE, 1996–2012), respectively. The analytic sample included 3037 and 1974 older adults aged 65 and over at baseline in Taiwan and Japan, respectively. Results The prevalence rate of loneliness for adults aged 65+ living in the community was 23.64% in Taiwan and 17.03% in Japan. Higher average levels (β Taiwan = 0.1508, P < 0.001) and rates of increment (β Taiwan*age = 0.0068, P < 0.05) in loneliness development were found in Taiwan as compared with Japan. In addition, although women reported higher levels of loneliness compared with men at age 65 (29.0% vs. 19.4% in Taiwan, and 19.3% vs. 13.9% in Japan), a soaring development of loneliness with accelerated rates of increment after age 65 was observed in men in both countries. Conclusions Lonliness in old age is very different between men and women. Women's loneliness curve shows an inverted U state: Although they feel more lonely than men during midlife, it has a downward trend as they get older. On the contrary, men's loneliness curve shows an upward U‐shaped curve: After retirement, both Japanese and Taiwanese men continue to rise. Geriatr Gerontol Int 2025; ••: ••–•• .

The field of music generation using Large Language Models (LLMs) is evolving rapidly, yet existing music notation systems, such as MIDI, ABC Notation, and MusicXML, remain too complex for effective fine-tuning of LLMs. These formats are difficult for both machines and humans to interpret due to their variability and intricate structure. To address these challenges, we introduce YNote, a simplified music notation system that uses only four characters to represent a note and its pitch. YNote's fixed format ensures consistency, making it easy to read and more suitable for fine-tuning LLMs. In our experiments, we fine-tuned GPT-2 (124M) on a YNote-encoded dataset and achieved BLEU and ROUGE scores of 0.883 and 0.766, respectively. With just two notes as prompts, the model was able to generate coherent and stylistically relevant music. We believe YNote offers a practical alternative to existing music notations for machine learning applications and has the potential to significantly enhance the quality of music generation using LLMs.

We simulate quench dynamics of the Su-Schrieffer-Heeger (SSH) chain on IBM quantum computers, calculating the Rényi entanglement entropy, the twist order parameter, and the Berry phase. The latter two quantities can be deduced from a slow-twist operator defined in the Lieb-Schultz-Mattis theorem. The Rényi entropy is obtained using a recently developed randomized measurement scheme. The twist order parameter and the Berry phase are measured without the need for additional gates or ancilla qubits. We consider quench protocols in which a trivial initial state evolves dynamically in time under the topological SSH Hamiltonian in the fully dimerized limit (the flat-band limit). During these quenches, there are persistent and periodic oscillations in the time evolution of both entanglement entropy and twist order parameter. Through the implementation of error mitigation techniques using a global depolarizing ansatz and postselection, our simulations on the IBM devices yield results that closely match exact solutions. Published by the American Physical Society 2025

This study aimed to investigate the relationship between the IL-28B SNP rs8099917 genotype, miRNA-122 expression, and the immune mechanism of ACR after LT using anti-HCV antibody calibration. A total of 45 patients with HCV received LT. IL-28B SNP rs8099917 genotyping was used to divide patients into TT and GT groups. The relative expression levels of miRNA-122 were calculated by quantitative PCR. Anti-HCV titers before and after LT were tracked to observe the relationship with ACR. The ACR rates were 27.6% for genotype TT and 62.5% for genotype GT, indicating a significantly higher rate in the GT group compared to the TT group (p = 0.024). In the rs8099917 genotype, TT was significantly associated with higher serum miRNA-122 levels than GT (p < 0.001). The TT group had significantly better outcomes than the GT group (p = 0.005). The Mann–Whitney U test showed significant differences in pre-LT and post-LT anti-HCV titers between the IL-28B genotypes (TT and GT) (p values of 0.006 and 0.027, respectively). These results suggested that the IL-28B rs8099917 genotype TT may play a significant role in modulating immune responses, both in terms of anti-HCV titers and the risk of ACR, possibly mediated through miRNA-122 levels.

Background The aim of this study is to investigate the real-world efficacy and safety of nivolumab in combination with chemotherapy for patients with advanced human epidermal growth factor receptor 2 (HER2)-negative gastric cancer (GC). Methods We enrolled patients diagnosed with unresectable advanced or metastatic GC who received nivolumab plus chemotherapy as first-line systemic treatment. The combined positive score (CPS), indicating the number of programmed cell death-ligand 1 (PD-L1)-stained cells, was utilized. Progression-free survival (PFS) and overall survival (OS) were analyzed using the Kaplan–Meier method. Adverse events (AEs) were graded, and treatment was ceased upon disease progression or intolerance. Results A total of 27 patients were included in the study, comprising 15 patients with CPS ≥ 5 and 12 patients with CPS < 5. The objective response rate (ORR) was 55.6%, with a disease control rate (DCR) of 74.1%. Patients in the CPS ≥ 5 group exhibited higher ORR and DCR compared to those in the CPS < 5 group. Median PFS and OS were 6.1 months and 14.6 months, respectively; patients with CPS ≥ 5 showed a trend towards better PFS and OS than those with CPS < 5. Most AEs were grade 1–2, with a few instances of grade 3–4 toxicities reported, including neutropenia, thrombocytopenia, diarrhea, and anemia. There were no grade 5 AEs reported in our cohort. Furthermore, 64.7% of patients received subsequent anticancer treatment following disease progression on nivolumab plus chemotherapy. Conclusions The results of our study demonstrate the efficacy and safety of nivolumab plus chemotherapy in real-world practice support its adoption as a new standard first-line treatment for patients with advanced HER2-negative GC, particularly those with CPS ≥ 5.

In a multiuser multiple-input multiple-output (MU-MIMO) downlink system, users are susceptible to interuser interference (IUI) because of data being simultaneously transmitted over the same time–frequency resources. Conventionally, precoding algorithms aim to eliminate the IUI. However, constructive interference (CI) precoding can achieve better error performance by exploiting the IUI. This article presents a high-throughput CI precoder. Design optimization across the algorithm and the architecture layers is conducted, reducing the complexity for multiplications by %. As the number of iterations for convergence varies, dynamic resource allocation is utilized to support each modulation mode with maximized utilization: time-multiplexing for the 4-QAM mode and parallel-processing for the 16-QAM mode. The proposed symbol updater also allows more efficient scheduling. As a proof of concept, a CI precoder chip that supports up to 16 \ttimes 16 MU-MIMO systems is designed based in a 40-nm CMOS technology. The performance gains at a bit error rate (BER) = 10 $^{-4}$ are 10.7 and 12.5 dB for 4-QAM and 16-QAM, respectively, compared with conventional regularized zero-forcing (RZF) schemes. The precoder delivers a maximum throughput of 3.2 Gb/s at a clock frequency of 200 MHz for the 16 \ttimes 16 MU-MIMO configuration.

This paper discusses the fabrication of three-dimensional dendritic Ag nanostructures, showcasing pronounced Localized Surface Plasmon Resonance (LSPR) effects. These nanostructures, employed in surface-enhanced Raman scattering (SERS), function as sensors for lactic acid in artificial sweat. The dendritic structures of the silver nanoparticles (AgNPs) create an effective SERS substrate, with additional hotspots at branch junctures enhancing LSPR. We achieve differential LSPR effects by varying the distribution and spacing of branches and the overall morphology. Adjustments to electrodeposition parameters, such as current and plating solution protective agents on an anodized aluminum oxide (AAO) base, allow for precise control over LSPR intensities. By pre-depositing AgNPs, the electron transmission paths during electrodeposition are modified, which leads to optimized dendritic morphology and enhanced LSPR effects. Parameter optimization produces elongated rods with main and secondary branches, covered with uniformly sized, densely packed, non-overlapping spherical AgNPs. This configuration enhances the LSPR effect by generating additional hotspots beyond the branch tips. Fine-tuning the electrodeposition parameters improved the AgNPs’ morphology, achieving uniform particle distribution and optimal spacing. Compared to non-SERS substrates, our structure amplified the Raman signal for lactic acid detection by five orders of magnitude. This method can effectively tailor SERS substrates for specific analytes and laser-based detection.