Young-Jae Lee's research while affiliated with Gachon University and other places
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Publications (38)
Rationale: Hereditary hemorrhagic telangiectasia (HHT) is a genetic disease caused by mutations in ENG, ALK1, or SMAD4. Since proteins from all three HHT genes are components of signal transduction of TGF-β family members, it has been hypothesized that HHT is a disease caused by defects in the ENG-ALK1-SMAD4 linear signaling. However, in vivo evide...
SMAD7 is a general inhibitor of transforming growth factor β (TGF-β) signaling that acts through interaction and degradation of TGF-β receptors. SMAD7 has been demonstrated to be transcriptionally upregulated in chemical-induced skin tumors and TGF-β-treated normal keratinocytes. To evaluate the function of SMAD7 in skin carcinogenesis in vivo, Sma...
This research is an extension of a previous research [1] on the different effects of sensor location that is relatively suitable for heart rate sensing. This research aimed to elucidate the causes of wide variations in heart rate measurements from the same sensor position among subjects, as observed in previous research [1], and to enhance designs...
Various forms of wearable bio-signal monitoring systems have been developed recently. Acquisition of stable bio-signal data for health care purposes needs to be unconscious and continuous without hindrance to the users` daily activities. The garment type is a suitable form of a wearable bio-signal monitoring system; however, motion artifacts caused...
In this study, a new type of electrode device is implemented to measure the capacitance energy and interpret it as the ECG (Electrocardiogram) data. The main idea of this new electrode system is to estimate the capacitance on the skin by assembling a capacitive-coupled circuits and translate into the ECG signal. To measure the coupling energy and e...
A robust new algorithm for R wave detection named for Multiscale-based Peak Detection(MSPD) is assessed in this paper using MIT/BIH Arrhythmia Database. MSPD algorithm is based on a matrix composed of local maximum and find R peaks using result of standard deviation in the matrix. Furthermore, By reducing needless procedure of Proposed algorithm, i...
Typically, studies through the simulation system have been progressed, because the evaluation of the driver`s arousal state about the service of a actual train has risk of safety for the driver. When configured event same as the real in simulation system, the ability to cope with an accident situation may be the same each other. But the difference...
There are many types of devices which help to manage a personal health conditions such as heartbeat chest belt, pedometer and smart watch. And the most common device has the relationship with heart rate or ECG data. However, users have to attach some electrode or fasten the belt on the bare skin to measure bio-signal information. Therefore, most of...
Objective:
Hereditary hemorrhagic telangiectasia is a genetic disorder characterized by visceral and mucocutaneous arteriovenous malformations (AVMs). Clinically indistinguishable hereditary hemorrhagic telangiectasia 1 and hereditary hemorrhagic telangiectasia 2 are caused by mutations in ENG and ALK1, respectively. In this study, we have compare...
Arteriovenous malformation (AVM) refers to a vascular anomaly where arteries and veins are directly connected through a complex, tangled web of abnormal AV fistulae without a normal capillary network. Hereditary hemorrhagic telangiectasia (HHT) types 1 and 2 arise from heterozygous mutations in endoglin (ENG) and activin receptor-like kinase 1 (ALK...
In order to detect blood volume changes, we proposed the new magnetic plethysmographic sensor using time-varying magnetic fields, and thereby, measuring the change of impedance of exciting coil. The change of coil impedance was proportional to the change of blood volume passing through a volume-of-interests, which inductively coupled with exciting...
In the research related to heart rate measurement, few studies have been done using magnetic-induced conductivity sensing methods to measure the heart rate. The aim of this study was to analyze the effect of the position of a textile-based inductive coil sensor on the measurement of the heart rate. In order to assess the capability of the textile-b...
In this study, physiological status of locomotive engineers were measured through EEG, ECG, EDA, PPG and respiration signals from 6 subjects to evaluate their arousal status during train operating. Existence of tunnels and mechanical vibration of train using 3-axes acceleration sensors were recorded simultaneously and were correlated with operator'...
For diagnostic and therapeutic purposes, the joint angle measurement of a patient after an accident or a surgical operation is significant for monitoring and evaluating the recovering process. This paper proposed an optical fiber sensor for the measurement of angular displacement. The effect of beveled fiber angle on the detected light signal was i...
A method for correcting life patterns for providing feedback for an exercise program periodically or in real time is disclosed. The method of the present invention detects a starting point of a dynamic activity interval periodically or in real time by sensing movement of a user in daily life, and provides an exercise program for filling a deficient...
The study for the passenger's comfortableness of vehicles and the arousal of car drivers has been done widely. On the other hand, there are few studies for the locomotive engineers. Human error means that the mistakes made by human, recently it receives attention in the field of safety engineering and human engineering. Comparing the operating cond...
In this study, a new blood pressure measuring system was proposed and implemented. An additional small-cuff was placed on the center of a inner cuff to measure morphological signals and new oscillometric ratio. The proposed BP-measuring system is composed of an external cuff, an inner cuff and a small-cuff. Oscillation signal from small-cuff is int...
Due to the possible occurrence of periodontal disease at an early age, it is important to have proper toothbrushing habits as early as possible. With this aim, the feasibility and concept of a smart toothbrush (ST) capable of tracing toothbrushing motion and orientation information was suggested. In this study, we proposed the advanced ST system an...
Purpose
The purpose of this paper is to study the conceptual design and optimisation of a compound gyroplane. A study of a compound gyroplane configuration and its characteristics was performed to develop a sizing program.
Design/methodology/approach
The vertical takeoff and landing capabilities of a helicopter are particularly important. The need...
This paper presents a low power discrete-time receiver supporting three broadcast services FM, T-DMB and DAB. To meet the requirement of sensitivity, three LNAs are implemented to cover each band. The proposed mixer core is terminated by a common-gate current buffer to improve linearity and merged with a switched-capacitor sampled filter in current...
A title listing the PCR primers for ACVRL1 and ENG genomic PCR. PCR primer sequences that were used for amplifying exons and their flanking intronic sequences for sequencing ACVRL1 and ENG genes.
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder, characterized by recurrent epistaxis, mucocutaneous telangiectases, and arteriovenous malformations (AVMs) in various visceral organs. Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1; ALK1), receptors for transforming growth factor-β (TGF-β) superfamil...
In this paper, we described the intelligent toothbrush system which is capable of monitoring three-dimensional brushing motion of toothbrush and analyzing brushing regions based on sensor signals measured from built-in accelerometer and magnetic sensors. In order to evaluate the efficacy of the proposed toothbrush system, we performed two experimen...
In this study, we proposed the system that calculates the algorithm with an accelerometer signal and detects the fall shock and it's direction. In order to gather the activity patterns of fall status and attach on the subject's body without consciousness, the device needs to be small. With this aim, it is attached on the right side of subject's wai...
Color is discerned due to the reflectance of object and its hue is determined by the Ratio of RGB spectrum. The aim of this study is to evaluate the Color information using by the optical system in terms of convenience and simplicity. Firstly, the differential Ratio of RGB is evaluated by photodiode Sensor which achieves a high efficiency with quic...
We measured the electrical activity signals of the heart through vital signs monitoring garments that have textile electrodes in conductive yarns while the subject is in stable and dynamic motion conditions. To measure the electrical activity signals of the heart during daily activities, four types of monitoring garment were proposed. Two experimen...
A portable and wireless activity monitoring system was developed for the estimation of temporal gait parameters. The new system was built using three-axis accelerometers to automatically detect walking steps with various walking speeds. The accuracy of walking step-peak detection algorithm was assessed by using a running machine with variable speed...
The purpose of this paper is to examine the unique features and current issues of National Health Insurance (NHI) in Korea and to propose future tasks and recommendations. NHI has improved the equity of insurance contributions and the efficiency of managerial operations by converting a society-based corporatist system with multiple insurers into a...
In order to monitor electrical activity of the heart during daily life, we present an electrode of a medical instrument system which is able to measure the body surface potential difference by minimizing the electrode distance. The designed electrode is composed of concentric circles. It was made from the basis of the Laplacian equation, and implem...
Wearable physiological signal monitoring systems are regarded as an important sensing unit platforms in ubiquitous/mobile healthcare application. In this paper, we suggested the modified bipolar electrodes implemented on the portable heart activity monitoring system, which minimized the distance of electrodes formed on a attachable pad. The propose...
To obtain a natural antioxidant from a marine biomass, this study investigated the antioxidative activity of methanolic extracts from the marine brown alga, Ishige okamurae collected off Jeju Island. A potent free radical scavenging activity was detected in the ethyl acetate fraction containing polyphenolic compounds, and the potent antioxidant elu...
An edible marine red alga, Grateloupia filicina, collected from Jeju Island of Korea was hydrolyzed by cheap food-grade carbohydrases (Viscozyme, Celluclast, AMG, Termamyl, and Ultraflo) to investigate its anticoagulant activity. Among the tested enzymatic extracts of G. filicina, a Termamyl extract showed the highest anticoagulant activity. Anion-...
The wearable patch-style heart activity monitoring system (HAMS) which was used for recording ECG signal in this study is self-developed. This electrode design helps the non-restricted, non-aware and non-invasive ECG measurement. The modified bipolar electrode is convenient in use because it is designed for easy attachment and detachment with ECG m...
Surface plasmon resonance is an important technique for studying molecular interactions and was used to investigate the molecular
interaction of anticoagulant sulfated polysaccharides purified from an enzymatic hydrolysate of the brown alga Ecklonia cava (ECA) with blood coagulation factors. In a direct binding assay, binding affinity between ECA/a...
The enzymatic extracts from seven species of microalgae (Pediastrum duplex, Dactylococcopsis fascicularis, Halochlorococcum porphyrae, Oltmannsiellopsis unicellularis, Achnanthes longipes, Navicula sp. and Amphora coffeaeformis) collected from three habitats (freshwater, tidal pool, and coastal benthic) at Jeju Island in Korea were investigated for...
The enzymatic extracts from seven species of micro-algae (Pediastrum duplex, Dactylococcopsis fascicula-ris, Halochlorococcum porphyrae, Oltmannsiellopsis unicellularis, Achnanthes longipes, Navicula sp. and Amphora coffeaeformis) collected from three habi-tats (freshwater, tidal pool, and coastal benthic) at Jeju Island in Korea were investigated...
The preventive effect of Lentinus edodes extract (LE) against constipation was studied in rats. Rats were pretreated with LE contained in drinking water at the concentration of 10%, 20% and 40% over 30 days. Constipation was induced by subcutaneous injection of loperamide (4 mg/kg/day) 3 days prior to sacrifice. Treatment of loperamide resulted in...
Effect of Cheonnyuncho extract on the liver injury of rats treated carbon tetrachloride was studied. Cheonnyuncho extract was administerd at dose of 0.5 and 1 g/kg/day, p.o. for 2 weeks. was treated at dose of , i.p. 3 hours later from the last pretreatment of Cheonnyuncho extract. Administration of Cheonnyuncho extract at a dose of 1 g/kg decrease...
Citations
... In order to validate this result and to assess the therapeutic potential of BMP9 or BMP10 in HHT, we performed the supplementation experiment on Scl-CreER( +);Eng 2f/2f (Eng-iKO) mice. We have previously shown that Eng deletion by an EC-specific Scl-CreER induced retinal AVM development [45]. The numbers of AVMs in the retinas of PBS-treated control and Eng-iKO mice (Fig. 8a, b) were compared with those of BMP9, BMP10, or both BMP9 and BMP10-treated Eng-iKO mice (Fig. 8c-e). ...
... Based on the hypothesis that SMAD7 deregulation is linked to several types of cancers (Ha et al., 2019;Tong et al., 2020;Troncone and Monteleone, 2019), we aimed to perform a bibliometric analysis on SMAD7 research in the scope of oncology. With the help of visualization analysis software such as CiteSpace and VOSviewer, the significance, centrality, and quality of publications, as well as their correlations, can be intuitively observed in the relationship network (Synnestvedt et al., 2005;van Eck and Waltman, 2010). ...
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... These can measure cardiac activity only in a state where certain parts of the body and the electrodes are completely compressed and in contact [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], which makes it difficult to acquire unconstrained and unconscious biosignals. To overcome this problem, some studies have been conducted on cardiac activity measurements using the noncontact capacitive method and magnetic-field-induction conductivity [16][17][18][19][20][21][22][23]. ...
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... These can measure cardiac activity only in a state where certain parts of the body and the electrodes are completely compressed and in contact [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], which makes it difficult to acquire unconstrained and unconscious biosignals. To overcome this problem, some studies have been conducted on cardiac activity measurements using the noncontact capacitive method and magnetic-field-induction conductivity [16][17][18][19][20][21][22][23]. ...
... This midday peak led to several hypotheses about the influence of certain passenger types at stations (the elderly, children) on incident propagation, with only a limited importance placed on the number of trains. Previous research suggests that the drastic change of environment at tunnel exit/entrance positively affects arousal levels, 33 but the preliminary assessment did not find this to be the case for Metro drivers, thus it requires further investigation. These findings generated the need for the following additional indicators and data: ...
... and highly angiogenic character of the vascular bed during development versus the relatively stable and quiescent nature of the vasculature at the adult stage. Accordingly, in adult mice, regional or tissue-specific CKO of Eng or Alk1 produced AVMs in the lung, brain and gastrointestinal tract but only if angiogenesis was simultaneously stimulated by VEGF [301][302][303] . This 'second hit' theory 304 postulates that a genetic predisposition (the first hit) in combination with an angiogenic trigger (for example, a repetitive injury; the second hit) leads to the reactivation of several developmental angiogenic pathways (for example, the TGFβ pathway) 303 . ...
... The HPM covering technical skills and non-technical skills in the transportation field is quite diverse. It relies on traditional and novel techniques, such as simulators [30], physiological data [31][32][33][34], and visual reality (VR) [30]. Meta-analytic research validated the use of cognitive ability, structured interviews, and several personality factors as predictors of training performance [35]. ...
... Recent studies indicate also potential utilizations of cactus cladodes and fruits (juices, concentrates and powders) as functional ingredients for the soft drink market ( Kim et al., 2013). The scientific community has been focused in the nutritional and health-promoting benefits of Opuntia spp (e.g., Ammar, Ennouri, & Attia, 2015;Chahdoura, Barreira, Barros, SantosBuelga, Ferreira, & Achour, 2014);Gopi, Kanimozhi, & Kavitha, 2015;Kwon & Song, 2005;Lee, Kim, & Lee, 2004;Park, Lee, & Kang, 2005;Stintzing, & Carle, 2005). Furthermore, cactus pear fruit is one of the most representative fruits in some cultures and has recently gained attention for its nutritional value. ...
... These results suggest that bifidus enhancer yogurt has a superior effect on relieving loperamide-induced constipation in rats. The results are similar to previous studies that examined the effects of mulberry leaves and lenitinus edodes extract on loperamide-induced constipation Park et al., 2007). ...
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... . 국내의 경우 전북대 연구팀에서는 동작분석시스템을 이용하 여 낙상시 신체 주요부위의 거동을 분석하고 충격량을 예측시 뮬레이션을 실시함과 동시에 낙상시 발생하는 가속도를 측정 함과 동시에 골절방지시스템을 고안한 바 있다 (5) . 한편 KIST와 건국대는 공동연구를 통하여 고령노인의 낙상 시 충격량을 측정하고 기립여부를 판단할 수 있는 시스템을 개 발하였다 (6) . 기존의 고분자물질로 제작되는 두꺼운 패드형태의 엉덩이 보 호대는 그 효과는 어느 정도 입증된 바 있으나 장시간 사용할 (2) . ...
