Yongjie Wang's research while affiliated with Jilin University and other places

Publications (10)

Article
Full-text available
Polyetheretherketone (PEEK) has gradually become the mainstream material for preparing orthopedic implants due to its similar elastic modulus to human bone, high strength, excellent wear resistance, radiolucency, and biocompatibility. Since the 1990s, PEEK has increasingly been used in orthopedics. Yet, the widespread application of PEEK is limited...
Article
Persistent fungal infections caused by biofilms seriously endanger human health. In this study, a photosensitizer‐polypeptide conjugate (PPa‐cP) comprising a photosensitizer, pyropheophorbide a (PPa), and a cationic polypeptide (cP) was readily synthesized for effective antifungal and antibiofilm treatment. Compared with free PPa, the cationic PPa‐...
Article
Full-text available
Retinal vein occlusion (RVO) is the second most prevalent retinal disease. Despite this, the pathogenic mechanisms and risk factors are not entirely clear. In this article, we review recent publications on the classification, pathogenesis, risk factors, ischemic changes, cytokines, and vital complications of RVO. Risk factors and cytokines are impo...
Article
Full-text available
Postoperative infections following implant-related spinal surgery are severe and disastrous complications for both orthopaedic surgeons and patients worldwide. They can cause neurological damage, disability, and death. To better understand the mechanism of these destructive complications and intervene in the process, further research is needed. The...
Article
Full-text available
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on. The pathological changes of...
Article
Full-text available
Objective: To study the effectiveness of a new spinal protection device for preventing and treating osteoporotic vertebral compression fractures (OVCFs) by finite element analysis (FEA). Methods: One healthy volunteer and one patient with 1-segment lumbar vertebral compression fractures were included in this experimental study. The DICOM files o...
Article
Bacterial infections and antibiotic resistance have become a global healthcare crisis. Herein, we designed and synthesized a series of cationic amphiphilic dendrons with cationic dendrons and hydrophobic alkyl chains for potential antibacterial applications. Our results showed that the antimicrobial activities of the cationic amphiphilic dendrons w...
Article
Full-text available
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma, genetic susceptibility, and other factors. It is closely associated with changes in tissue stru...
Article
Surgical site infections (SSIs) after spinal surgery are one of the serious complications of spinal surgery, which can lead to failure of spinal surgery, central nervous system infection, and even threaten patient lives. Although existing antibiotics can effectively control and treat postoperative infections in the spine, bacterial resistance conti...

Citations

... Therefore, IDD is difficult to repair by itself and is irreversible. In view of this feature, more and more teams have begun to use stem cells to intervene in the IDD process in order to slow down the IDD process or repair the degenerated intervertebral disc, including mesenchymal stem cells (MSC), intervertebral disc-derived stem cells (IVDSC), and pluripotent stem cells (PSC) [55]. ...
... The nature of vertebral degeneration is osteoporosis, which manifests as decreased calcium deposition in vertebral bone and obvious bone loss, resulting in bone microstructure destruction and a decreased elastic modulus. The weight bearing capacity of the vertebral body is significantly reduced, and spinal compression fracture may occur after even a minor trauma [13]. The composition of the spine and the pathogenesis of degenerative disease are shown in Fig. 1. ...
... 21,22 Recently, small amphiphilic dendrimers composed of hydrophobic entities and hydrophilic dendrons were shown to have antibacterial activity that was frequently related to low dendrimer generation, terminal charge, and hydrophilicity/ hydrophobicity balance. [23][24][25][26][27][28][29][30][31][32] Specifically, various peptide, polylysine and poly(amide) dendrimers were synthesized to improve their antimicrobial activity, [23][24][25][26][27] whereas polyester dendrimers were explored for imparting biodegradability while reducing toxicity. [30][31][32] Also, amphiphilic dendrimers with carbosilane entities 28 and poly(aryl ether) backbones 29 were studied for antibacterial activity. ...
... To date, a series of studies have demonstrated that proinflammatory molecules are potent factors in initiation and progression of IDD [11,12]. Many important 10 Oxidative Medicine and Cellular Longevity inflammatory biomarkers have been investigated and have the potential to guide diagnosis and therapeutics [13]. ...
... The L-shaped stainless steel implant (0.1 mm in diameter) was then placed into the defect. The long arm of the implant was longitudinally placed along the spine heading cranially with the short arm in the spine, as shown in our previous study 54 . An inoculation of sterile saline or 1 Â 10 2 , 1 Â 10 3 , or 1 Â 10 4 CFUs of bioluminescent Xen36 S. aureus was applied to the 90 bend of the stainless steel. ...