Yonggui Robin Chi’s research while affiliated with Nanyang Normal University and other places

... [22] Numerous researchers have already realized the potential advantages of the generation of glycosyl radicals under photoredox conditions. [23] Correspondingly, multiple anomeric derivatives, such as glycosyl halides, [24][25][26] sulfoxides, [27,28] sulfinates, [29,30] sulfones, [31][32][33] and dihydropyridyl esters, [34][35][36][37][38] amongst others [39] have been developed as photoredox activatable precursors of glycosyl radicals. However, in the vast majority of cases, reactions either involved photoredox activation of protected carbohydrate derivatives, or in the few cases where unprotected glycosyl radicals were formed, protecting group manipulations were required in order to make the glycosyl radical precursors themselves. ...

Reference:

One‐Step Aqueous Synthesis of Glycosyl Pyridinium Salts, Electrochemical Study, and Assessment of Utility as Precursors of Glycosyl Radicals Using Photoredox Catalysis

... For the construction of optically active sulfonimidamides, the traditional approach mainly relied on a chiral substrate strategy, through the nucleophilic substitution reaction of chiral sulfonimidoyl halides with different amines. [9][10][11][12][13][14] In 2021, Willis and co-workers reported that para-methoxybenzyl (PMB) protected N,N 0 -sulfonimidamides are prone to rapid tautomerization under a variety of conditions, such as in toluene, upon treatment with KOH, or upon addition of triuoroacetic acid, creating opportunities for asymmetric catalysis. Using bisquaternized cinchona alkaloid Cat. 1 as the phase-transfer catalyst, Willis and co-workers developed the rst catalytic enantioselective desymmetrization of sulfonimidamides via an asymmetric alkylation reaction, generating enantiomerically enriched sulfonimidamides in excellent yields and enantioselectivities (Scheme 1a). ...

Reference:

Pyridine-N-oxide catalyzed asymmetric N-acylative desymmetrization of sulfonimidamides

... [98][99][100][101][102] The DFT method has been confirmed to be a good choice to study the reaction mechanism in QM part. [103][104][105][106][107][108] Fig. 2 depicts the uricase-catalyzed oxidation reaction pathway for 8-HX in detail. In this process, the first step involves the transfer of protons from the substrate 8-HX to the N z atom of the residue K9 with the assistance of residue T69, while electron transfer occurs from 8-HX to the oxygen molecule to activate O 2 via transition state 2ts t (10.0 kcal mol À1 ). ...

Reference:

Unraveling proton-coupled electron transfer in cofactor-free oxidase- and oxygenase-catalyzed oxygen activation: a theoretical view

... Plant diseases cause huge losses in the world's crops every year, resulting in reduced crop yields and threatening food safety. 1 Different types of fungicides have been widely used in agriculture to solve these problems. 2,3 However, the long-term use of current commercial fungicides has resulted in increasing resistance of plant pathogenic fungi, which not only makes plant disease control less efficient but also increases the cost of pesticide usage and the threat of pesticide residue to the environment. 4 Therefore, it is particularly important to develop new chemical fungicides that are efficient, environmentally friendly, and broad-spectrum to overcome the developed resistance. ...

Reference:

Synthesis, antifungal activity, and molecular simulation study of nootkatone‐based thiazole‐hydrazone compounds as novel succinate dehydrogenase inhibitor

... 51−54 Very recently, the group of Tan has demonstrated an intriguing enantioselective condensation approach to access S-chiral sulfinate esters with readily accessible potassium sulfinates through catalytically generated enantioenriched mixed anhydride intermediates ( Figure 1C). 55 Prompted by these remarkable successes and our broad interest in the catalytic construction of unique heteroatomstereogenic compounds, 56,57 we envisioned the activation of feedstock phosphinic acids through the formation of mixed phosphinic anhydrides as reactive species to facilitate further catalyst-controlled asymmetric P−O bond formations with alcohol nucleophiles. 58 Herein, we disclose an organocatalytic enantioselective condensation strategy for rapid access to a broad set of phosphorus(V) stereogenic scaffolds with readily available and stable phosphinic acids ( Figure 1D). ...

Reference:

Synthesis of P(V)-Stereogenic Phosphorus Compounds via Organocatalytic Asymmetric Condensation

... 1,2 Fungicides remain the most effective and economical way to prevent and control fungal diseases in crops. [3][4][5] Succinate dehydrogenase inhibitors (SDHIs), which have excellent antifungal and broad-spectrum properties, are the fastest growing class of biocides in terms of production and launches in the rapidly expanding fungicide market. 6,7 However, the misuse of SDHI fungicides over the last few decades and single-target has led to a growing resistance problem, and the Fungicide Resistance Action Committee (FRAC) (www.frac.info) ...

Reference:

Design and development of pyrazol‐5‐ylbenzamide derivatives containing chiral oxazoline moiety as fungicides based on molecular docking

... Case in point, NHC-catalysed desymmetrisation of prochiral or meso-compounds 7,8 stands out as a highly promising platform for enantioselective transformations (Fig. 1A) 9,10 . More specifically, NHC-catalysed stereoselective oxidative esterification of prochiral aldehydes offers a versatile pathway to various products with central chirality, including dihydropyridines 11 , and noncarbon stereogenic centers [12][13][14] . In the last two years, though, research has increasingly focused on the development of axially chiral compounds [15][16][17] . ...

Reference:

Desymmetric esterification catalysed by bifunctional chiral N-heterocyclic carbenes provides access to inherently chiral calix[4]arenes

... As for nitrogen nucleophiles, direct catalytic enantioselective N-acylation reaction is challenging, [17][18][19][20][21][22] mainly due to the strong nucleophilicity of amines leading to strong background reactions. In 2023, Lim, Toste, Sigman, and co-workers reported a palladium-catalyzed enantioselective aryl-carbonylation of sulfonimidamides with aryl and heteroaryl iodides, affording diverse enantioenriched mono-acylation sulfonimidamides in excellent results (Scheme 1b). ...

Reference:

Pyridine-N-oxide catalyzed asymmetric N-acylative desymmetrization of sulfonimidamides

... Herbicidal activity tests and data evaluation were performed at application rates of 75 to 150 g ai/ha, referencing methods reported in previous literature. 36,37 Weed seeds were planted in plastic pots with an inner diameter of 8 cm and incubated in a greenhouse under alternating temperatures of 15°C (night, 12 h) and 25°C (day, 12 h). After approximately 2 weeks, both Abutilon theophrasti and Digitaria sanguinalis reached the third leaf stage. ...

Reference:

Discovery of novel benzoxazinone derivatives as promising protoporphyrinogen IX oxidase inhibitors

... 27 Recent sequential work by Li et al.'s group 28 has developed a series of potential fungicidal candidate containing chiral oxazoline ( Fig. 1(B)) as SDHIs and found that fine-tuning the chiral substituent of the oxazoline significantly affects the antifungal activities. In addition, indole derivatives containing different chiral oxazoline moieties ( Fig. 1(C)) designed by Huang et al. 29 exhibited significantly different biological activities against Potato virus Y (PVY). Encouraged by these works, we envisage that this interesting chiral oxazoline scaffold could facilitate the development of novel pesticides. ...

Reference:

Design and development of pyrazol‐5‐ylbenzamide derivatives containing chiral oxazoline moiety as fungicides based on molecular docking