Yongdong Jin’s research while affiliated with State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry and other places

... When exosomal miRNAs of cancer cells and normal cells were analyzed, exosomes derived from cancer cells were richer in miRNAs. In addition, exosomal miRNA levels were found to increase when cells were subjected to electrical stimulation [81]. miRNA-seq was performed on urinary exosomes from renal-cell carcinoma patients and healthy controls, and an increased expression of miR-542-5p and decreased expression of miR-320a were observed in cancer patients [82]. ...

Reference:

Recent Exploration of Solid Cancer Biomarkers Hidden Within Urine or Blood Exosomes That Provide Fundamental Information for Future Cancer Diagnostics

... Additionally, MX's large surface area and tunable chemistry allow for facile functionalization and loading of therapeutic agents [ 21 ] as a platform for dual-mode cancer therapy [ 22 , 23 ]. For examples, MX was used for the photothermal and electrical stimulation co-therapy [ 24 ], PTT and enzymatic dynamic therapy accompanied by photoacoustic imaging [ 25 ], and synergistic sonodynamic/chemo dynamic therapy [ 26 ]. However, the direct use of MX in cancer therapy has been limited by challenges such as the aggregation in the physiological environment, the reduced stability, and the difficulty in combining its photothermal properties with long termcontrolled drug delivery [ 27 ]. ...

Reference:

MXene/Doxorubicin Complex-Loaded Supramolecular Hydrogels for Near Infrared-Triggered Synergistic Cancer Therapy

... Traditional studies of this kind mostly focused on the modification of the inner channel wall of the nanopores, since they come into contact with the transported ions directly and are easily manipulated to regulate the transmission behaviors. Although the deposition of a layer of metal such as gold on the outer surface of solid-state nanopores followed by grafting nucleic acids or metal-organic framework on the metal layer has been implemented in some studies to improve detection sensitivity [36−38], the contribution of the elements on the outer surface of glass nanopipette was always ignored [39] and has not been exploited for the design of potential new nanofluidic devices. So far, most nanofluidic devices with complex functions and modification steps were concentrated on polyethylene terephthalate (PET) nanopores or carbon nanotubes, while for the glass nanopipettes, they function only by simply changing the solution conditions [17]. ...

Reference:

Bioinspired polydopamine coated nanopore nanofluidic unijunction transistor exhibiting negative differential resistance and ion current oscillation

... There was an urgent need to develop new candidate drugs for the treatment of esophageal cancer. NCL was a multifunctional nuclear protein that was overexpressed in the cell membrane, cytoplasm, and nucleus of cancer cells and played an important role in regulating the physiological activities of cells [26]. Considering the key role of NCL in cancer development, some studies have studied NCL as a key receptor for therapeutic agents and imaging probes. ...

Reference:

A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer

... 75 Concerning the combination of NIR and ES, a Ti 3 C 2 T x acid acrylic ionic gel enhanced skin wound healing due to combined NIR antibacterial effects on E. coli and S. aureus and increased cell migration due to ES in infected mice. 74 In this study, while the inflammation and necrotic tissue were evident in the wounds in the control, only the combined ES and PTT, decreased the margins of the wound with enhanced collagen deposition, lower expression of TNF-α and upregulation of FGF-2. ...

Reference:

Advanced approaches in skin wound healing – a review on the multifunctional properties of MXenes in therapy and sensing

... [37,38] Previous studies have shown that the concentration of miRNA-21 is rising during the apoptosis process of tumor cells. [39] Therefore, we designed DNA probe (MB-21) with miRNA-21 dectection ability to verify the capability of USD to induce apoptosis ( Figure S22 and S23), and the results were validated using standard RT-qPCR test (Figure S24). The results confirmed a significant upregulation of miRNA content in HeLa cells treated with USD plus NIR, demonstrating the ability of USD to promote apoptosis. ...

Reference:

Near‐Infrared Light‐Triggered Cascade Nanosystems for Spatiotemporally Controlled Gene‐Silencing and Gas Synergistic Cancer Therapy

... Metal-organic frameworks (MOFs) offer significant advantages over other nanocarriers used for cancer treatment. They possess a highly porous structure, allowing for high drug loading capacity and controlled release, which is crucial for targeted therapy [14]. Our platform utilizes the photodynamic and photothermal properties of this composite MOFs, which then enhanced by copper doping and gold nanoparticle decoration [15,16]. ...

Reference:

Gold nanoparticles/Cu decorated metal–organic frameworks for synergistic photodynamic/ferroptosis cancer therapy

... Monitoring the dynamic changes of active components within a biological system is crucial in drug development. SERS technology, with its high temporal resolution, is particularly suited for real-time monitoring of molecular dynamics [71,72]. This includes processes such as absorption, distribution, metabolism, and excretion (ADME) of drugs [73]. ...

Reference:

Surface-enhanced Raman spectroscopy in pharmaceutical analysis: from component determination to mechanism research

... Table S1 (in Supplementary Materials) summarizes the comparison between Trolox detection performance using different methods [12,19,[52][53][54]. The LOD obtained using the fabricated sensor is lower than that obtained by differential pulse voltammetry (DPV) detection using a copper-neocuproine complex ([Cu(Nc) 2 ] 2+ ) probe [52], or a square-wave voltammetry (SWV) detection using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) probe [19], or electrochemiluminescence (ECL) detection based on luminol emitter [53,54], or colorimetric detection using Fe(III)(phen) 3 probe [12]. Thus, the fabricated sensor also has advantages of convenient fabrication, simple detection, and high sensitivity, demonstrating great potential for TAC determination. to measure the electrochemical oxidation current of Fe(II)(phen)3 using chronoamperometry. ...

Reference:

Direct and Sensitive Electrochemical Determination of Total Antioxidant Capacity in Foods Using Nanochannel-Based Enrichment of Redox Probes

... Based on the literature, it has been observed that tumor cells exhibit a comparatively higher susceptibility to external stimulation than normal cells, particularly with regards to their cytoskeletal structure [197]. For instance, Jin's group from State Key Laboratory of Electroanalytical Chemistry of Chinese Academy of Sciences [198] demonstrated that electrostimulation (ES) significantly inhibits glucose and energy metabolism in cancer cells, resulting in rapid cell death (Figure 8A-C). From a mechanical perspective, ES leads to cytoskeletal disruption (Figure 8D), which reduces the Young's modulus of MCF-7 cell membranes ( Figure 8E) due to the depolymerization of F-actin and the down regulation and irregular distribution of glucose transporter 1 (GLUT1) (Figure 8F). ...

Reference:

Unveiling the potential of biomechanics in pioneering innovative strategies for cancer therapy