Yong Bae Kim’s research while affiliated with Severance Hospital and other places

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Publications (442)


Role of radiotherapy in the management of breast cancer with skin involvement
  • Article

April 2025

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1 Read

Radiation Oncology Journal

Sun Ho Min

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Yong Bae Kim

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[...]

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Hwa Kyung Byun




Abbreviations: DCIS = ductal carcinoma in situ; ER = estrogen receptor; HER2 = human epidermal growth factor receptor 2; IDC = invasive ductal carcinoma; ILC = invasive lobular carcinoma; IQR = interquartile range; PR = progesterone receptor; RT = radiation therapy; uHF = ultrahypofractionated radiation therapy (26 Gy in 5 fractions); VMAT = volumetric modulated arc therapy. *Adjuvant trastuzumab therapy among 72 patients with HER2-positive breast cancer. yAdjuvant hormone therapy among 385 patients with ER-or PRpositive breast cancer.
Patient characteristics of the VMAT-uHF group (n = 476)
Volumetric Modulated Arc Therapy for 26 Gy in 5 Fractions Whole Breast Irradiation for Breast Cancer
  • Article
  • Full-text available

February 2025

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18 Reads

Advances in Radiation Oncology

Purpose To report the dosimetric and toxicity outcomes of patients treated with 26 Gy in 5 fractions ultrahypofractionated (uHF) whole breast irradiation (WBI) using volumetric arc therapy (VMAT). Methods and Materials We identified 476 consecutive patients who underwent WBI using VMAT-uHF between 2020 and 2021. Study endpoints included acute toxicity and dosimetric parameters for target volume and organs at risk. The dosimetric results were compared with a historical cohort at the same institution who were treated with moderately hypofractionated WBI using 3-dimensional (3D)-conformal radiation therapy (3D-CRT, n = 392), with the total dose rescaled to 26 Gy. Results VMAT-uHF achieved a mean D95% and Dmax of the planning target volume of 96.2% and 102.8% of the prescribed dose, respectively. The VMAT-uHF group demonstrated significantly superior planning target volume coverage and improved dose homogeneity, with a 30.6% higher D95 and a 0.7% lower Dmax compared with the 3D-CRT group (both P < .05). Mean doses for the ipsilateral lung and heart were 3.12 ± 4.59 Gy and 0.92 ± 0.25 Gy, respectively, showing differences of < 0.3 Gy compared with the 3D-CRT group. The VMAT-uHF group exhibited a significantly lower left anterior descending artery Dmax (−3.73 Gy), while the contralateral breast showed a higher Dmean (+1.43 Gy), compared with the 3D-CRT group. Acute toxicity following VMAT-uHF was predominantly mild, with grade 1 toxicity observed in 114 out of 120 patients. No additional toxicities were reported after a median follow-up of 21.2 months. Conclusions The application of VMAT in ultrahypofractionation can enhance target coverage while maintaining radiation doses to organs at risk low, albeit with an increase in contralateral breast dose compared with 3D-CRT. Given the low toxicity profile observed in our cohort with VMAT-uHF, the clinical significance of these dosimetric differences requires further investigation.

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The first Korean carbon-ion radiation therapy facility: current status of the Heavy-ion Therapy Center at the Yonsei Cancer Center

December 2024

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35 Reads

Radiation Oncology Journal

Purpose: This report offers a detailed examination of the inception and current state of the Heavy-ion Therapy Center (HITC) at the Yonsei Cancer Center (YCC), setting it apart as the world’s first center equipped with a fixed beam and two superconducting gantries for carbon-ion radiation therapy (CIRT). Materials and Methods: Preparations for CIRT at YCC began in 2013; accordingly, this center has completed a decade of meticulous planning and culminating since the operational commencement of the HITC in April 2023. Results: This report elaborates on the clinical preparation for adopting CIRT in Korea. It includes an extensive description of HITC’s facility layout at YCC, which comprises the accelerator and treatment rooms. Furthermore, this report delineates the clinical workflow, criteria for CIRT application, and the rigorous quality assurance processes implemented at YCC. It highlights YCC’s sophisticated radiation therapy infrastructure, collaborative initiatives, and the efficacious treatment of >200 prostate cancer cases utilizing CIRT. Conclusion: This manuscript concludes by discussing the prospective influence of CIRT on the medical domain within Korea, spotlighting YCC’s pioneering contribution and forecasting the widespread integration of this groundbreaking technology.




Citations (53)


... Studies exploring their utility suggest that patients value the immediacy of responses, the ability to pose questions multiple times without feeling guilty, and the non-judgmental tone. In these investigations, participants reported improved recall of basic information about side effects and were more likely to adhere to recommended screening intervals [29][30][31][32][33]. ...

Reference:

Evidence-Based Analysis of AI Chatbots in Oncology Patient Education: Implications for Trust, Perceived Realness, and Misinformation Management
A study on BReast cancer patient care using chAtbot and Video Education for radiation therapy (BRAVE): A randomized controlled trial
  • Citing Article
  • December 2024

International Journal of Radiation Oncology*Biology*Physics

... While some technological advancements are still far from clinical application, others have been quickly adopted in the field of radiation oncology. This special issue features three reviews that highlight recent advancements in RT technologies, specifically particle therapy [1], FLASH RT [2], and artificial intelligence (AI) [3]. These articles also discuss the future prospects of these technologies. ...

Clinical indications and future directions of carbon-ion radiotherapy: a narrative review
  • Citing Article
  • October 2024

The Ewha Medical Journal

... Some systemic agents may be associated with increased risk of radiation necrosis, for example concurrent trastuzumab emtansine was associated with ~ 30% RN risk, highlighting the need to carefully and specifically evaluate each drug in combination with RT [36]. ...

Risk of radionecrosis in HER2-positive breast cancer with brain metastasis receiving trastuzumab emtansine (T-DM1) and brain stereotactic radiosurgery
  • Citing Article
  • July 2024

Radiotherapy and Oncology

... To investigate the correlation between the complexity of the given VMAT plans and the deliverability of the VMAT plans (quantified by GPR), we calculated several plan complexity metrics using the open-source algorithm, available on GitHub (22) (http://github.com/AurelienCD/DeepHybrid Learning_RadiotherapyQA_Depository_ManuscriptID_ Diagnostics), which has been employed for previous studies (23)(24)(25). This work computed six plan complexity indices as follows: small aperture score (SAS), leaf travel (LT), modulation complexity score for VMAT plans (MCSv), combination of LT and MCSv (LTMCS), aperture area variability (AAV), and leaf sequence variability (LSV). ...

Generating 3D images of VMAT plans for predictive models and activation maps associated with plan deliverability

... The EORTC Core Quality of Life (EORTC QLQ-C30) questionnaire is designed to measure the physical, psychological, and social functions of cancer patients. It comprises multi-item scales and single items [29]. This questionnaire evaluates the life quality of cancer patients and includes nine multi-item scales: five functional scales (physical, role, cognitive, emotional, and social), three symptom scales (fatigue, pain, and nausea and vomiting), and a global health status scale. ...

Symptom Network and Quality of Life of Breast Cancer Patients Receiving Multimodal Cancer Treatment: Cross-sectional Study
  • Citing Article
  • July 2024

European Journal of Oncology Nursing

... Unexpected infarction caused by branch occlusions or hemodynamically relevant constrictions, and insufficient aneurysm occlusion can be detected in postoperative radiologic imagine even in the most experienced centers. Han HJ et al. demonstrated overall incidence of postclipping cerebral infarction was 16.7% based analysis of 605 cases with unruptured intracranial aneurysms 13 . So any refinement of the techniques is desirable. ...

Incidence and Characteristics of Cerebral Infarction After Microsurgical Clipping of Unruptured Anterior Circulation Cerebral Aneurysms: Diffusion-Weighted Imaging-Based Analysis of 600 Patients
  • Citing Article
  • June 2024

Neurosurgery

... Another benefit of oversizing is diminished risk of aneurysmal endoleak, which might compromise treatment outcomes (40). A key aspect of oversizing is the decreased risk of stent migration Finally, oversizing increases the implant porosity, which might aid in keeping the covered side branches patent and functional (41). A drawback of oversizing observed herein was that this increased porosity was a risk factor for aneurysm occlusion, because of the diminished flow disturbance inside the sac. ...

Quantitative analysis of hemodynamic changes induced by the discrepancy between the sizes of the flow diverter and parent artery

... Modality conversion involves transforming data from one form to another, which is crucial for enabling AI to mimic human-like sensory integration and interpretation. One example in the field of radiation therapy is the use of DL tools for the generation of synthetic CT images from magnetic resonance images to aid in radiation therapy planning 124 . Transformer-based text, vision, and speech models can facilitate these conversions. ...

Clinical feasibility of deep learning-based synthetic CT images from T2-weighted MR images for cervical cancer patients compared to MRCAT

... However, as mentioned earlier, while previous studies have demonstrated that the COW's anatomy is associated with the occurrence of intracranial artery aneurysms, investigations specifically addressing the hemodynamic characteristics of the COW, such as shear stress, have been relatively rare. Recently, additional research efforts have been made (12), though the causal relationship remains a subject of ongoing debate (13). ...

Influence of circle of Willis modeling on hemodynamic parameters in anterior communicating artery aneurysms and recommendations for model selection