Yixiang Liu's research while affiliated with Jimei University and other places

... Specifically, vitamin A and vitamin D can strengthen the intestinal epithelial barrier function by stabilizing the mucosal immune system, thus affecting the process of intestinal inflammation (223). Additionally, the administration of vitamin A and vitamin D can influence intestinal microflora, including elevating the number of helpful bacteria (like Clostridaceae) and lowering the number of pathogenic bacteria (like Streptococcaceae) (224), which can also improve the relevant metabolites of the intestinal microflora, like elevating the production of SCFA (225), which can effectively improve metabolic diseases and restore the intestinal barrier function. Recent research has also demonstrated the ability of VB12 oral supplement to participate in the epigenetic modification of intestinal barrier genes, limit the colonization of harmful bacteria, and coordinate the functions of ileal epithelial cells (iEC) and intestinal microbiota (226). ...

... Currently, more than 300 million people pharmacokinetics, prolonging blood circulation time and reducing the toxic side effects of drugs [19]. Due to their unique physicochemical properties, such as controllable size, good biocompatibility and low cytotoxicity, micro/nanoparticles have become a hot topic of research for researchers in many fields [20][21][22]. Among many micro/nanomaterials, poly (D,L-lactide-co-glycolide) (PLGA) copolymers are approved for medical use by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as polymeric organic compounds with excellent biocompatibility, biodegradability and unique physical and chemical properties, making them one of the most popular and efficient polymers for drug delivery [23][24][25]. ...

... It is reported that the gut is a primal portal for food allergens, meanwhile the damage of the gut barrier and dysbiosis of the gut microbiota are likely to bring about food allergies. Accordingly, the gut epithelium is crucial to improve tolerance for potentially oral-ingested food allergens (Han, Ma, and Liu 2022). The tight junction (TJ) proteins are used to seal the paracellular spaces between the epithelial cells, that are critical to sustain gut epithelial barrier integrity and prevent harmful substances entry. ...

... Anthocyanins such as cyanidin 3-O-glucoside increased total β-defensin protein levels in the intestinal mucosa of mice in an ovalbumin-induced food allergy model [74]. A blueberry powder, high in anthocyanins, supplemented in a high fat diet of rats for 8 weeks significantly increased Defb2 mRNA expression by 2-fold in the ileum compared to rats on a low-fat diet [75]. ...

... Consistent with previous studies, C3G protects mouse hepatocytes against apoptosis induced by high glucose levels via mitochondria and the PI3K-AKT signaling pathway [33]. Furthermore, C3G also mediates protection against many other physical and chemical substances via endoplasmic reticulum stress-and oxidative stress-induced apoptosis in many animal cells [34][35][36][37]. Although oxidative phosphorylation and the mitogen-activated protein kinase (MAPK) signaling pathway, and others, also varied in our RNA-seq data, they were not addressed in the current work, which was a deficiency and will be further explored in the future. ...

... They used bovine serum albumin to fabricate with particle size in the range of 113-193 nm. Additionally, the high EE (about 95%) of astaxanthin by bovine serum albumin-fatty acid nanoparticles was reported by Huang et al. [41]. Data are expressed as mean ± SD (n = 3). ...

... Without being a panacea, natural colorants, particularly C3G, now appear as a healthy and promising alternative to synthetic dyes, and their application fields continue to grow year after year. Despite these functional attributes, C3G is poorly bioavailable and its absorption in the small intestine is very limited, which affects its functionality in vivo [4][5][6]. However, the major shortcoming of this class of bioactive compound is its instability. ...

... NaCas displays a good binding ability to small molecules, as well as excellent stability and self-assembly properties [14,18]. Based on the previous research in our laboratory, oleic acid (OA) can form water-soluble particles with bovine serum protein, which can improve the stability and bioavailability of fat-soluble active substances [19]. In addition, OA binds tightly to casein and increases its hydrophobicity [20]. ...

... In addition, supplementation with 100 ppm botanical blend 2 increased the relative abundance of Muribaculaceae in the cecum compared with the positive control. Muribaculaceae is often known to be one of the predominant families found in mouse cecal microbiota and their abundance can be altered by diets [65,66]. However, the major function of Muribaculaceae in the intestine of pigs is not well understood. ...

... Carbohydrates are digested and subsequently fermented into SCFAs in the colon, where they are carried through the bloodstream to various organs (e.g., muscle and adipose tissues) and used as substrates for gluconeogenesis and lipogenesis [48]. In a BALB/c allergen mouse model, reduction of the Helicobacteraceae family (Proteobacteria phylum) reduced inflammatory biomarkers by disrupting the recycling of tight junction proteins that form the physical and immunologic barrier of the intestinal epithelium [49]. Disruption of the tight junction of the mucosal epithelial cells may damage the water transport and mucosal hydration function. ...