Yingze Li's research while affiliated with Tongji University and other places

... Despite these advances, lung cancer continues to pose a significant public burden that is heightened by its dismal overall prognosis, poor clinical outcome, and a five-year survival rate of only 18% in the US, which is among the lowest across early-stage malignancies [13]. These sub-optimal outcomes are attributed to multiple factors, including low screening adherence (4-6% of potential eligible candidates in the United States) [14] as well as resistance of certain of patient subgroups to specific treatment strategies [15]. For instance, durable benefits in response to single-agent ICB are limited to a subset of patients, and this setback highlighted an urgent need to better identify biomarkers to stratify patients who are likely to respond to ICB and to determine the best window of time for therapeutic intervention [16]. ...

... Intracerebral neurotoxicity and metabolic pathways of inorganic nanoparticles are hot topics in this field. Studies revealed that up to 90% of intratumorally injected IONPs are recognized and phagocytosed by tumorassociated microglia and macrophages (Feng, Xu, et al., 2021). Extracellular vesicle-encapsulated nanoparticles could be gradually eliminated from the brain with cerebrospinal fluid circulation within 21 days and showed no apparent neurotoxicity. ...

... However, due to either the aggregation of high content magnetic nanoparticles or relatively complex in situ precipitation process, magnetic nanoparticles fail to be easily integrated with the existing preparation methods, enabling most magnetic hydrogels weak and brittle. The mechanical weakness, particularly the trade-off between tensile strength and toughness, thus confines them to only utilize in the fields, such as heavy metal adsorption, drug delivery and enzyme immobilization [4][5][6]. It is highly desirable to develop an effective strategy to synthesize strong and tough magnetic hydrogels to enlarge their applications. ...

... For example, Malfa et al. found that an extract of Betula aetnensis Rafin can upregulate the expression of heme oxygenase-1 (HO-1), induce ferroptosis, and result in cell death in Caco2 cell lines [8]. In addition, Li et al. applied iron-based nanomaterials to tumor therapy for a better induction effect of ferroptosis and a more efficient anticancer condition [9]. In CC, a biocompatible fusiform iron oxide-hydroxide nanospindle (FeOOH NSs) nanosystem was created by Li et al. for specific treatment, as it causes cell death via ferroptosis [10]. ...

... In tortuous distal vascular regions, these devices need to achieve shape adaption for changing lumen diameters, withstand the flow even if the external actuation is disrupted or turned off (i.e., self-anchoring capability) for safe local operations, traverse among curved routes and bifurcations, and be movable against the blood flow for retrieval or mistaken navigation. However, all the previous works have shown limitations in concurrently fulfilling all of these requirements [18][19][20][21][22][23][24][25][26][27] . Notably, most of the previous designs lack the self-anchoring capability with the surrounding lumen and could be drifted away by the pulsatile flow. ...

... During the circulation in vitro, the blood is subjected to a rotational magnetic field. Based on the above-mentioned cases, the rotational magnetic field will actuate the magnetic nanochains to rupture the organelles including the lysosomes and the cytoskeletons so that the cellular environment turns acidic, facilitating the release of DOX and the apoptosis of cancerous cells [34][35][36][37]. Moreover, another advantage of this strategy is that the magnetic assembly is facile to get prompt separation. ...

... (ii) During dissection, it is mandatory to expose the target PA by more than two thirds of its circumference in order to close the entire vessel with a proximal and distal suture as also reported in other series. 8, 11 (iii) The needle should be passed across the nodes and not across the vessels to avoid vascular injury. Our procedure is indicated in selected cases such as patients with calcified or inflammatory LNs between the target PA and the bronchial tree. ...