Yingze Li's research while affiliated with Tongji University and other places

Publications (11)

Article
Full-text available
The foreign body response (FBR) caused by biomaterials can essentially be understood as the interaction between the immune microenvironment and biomaterials, which has severely impeded the application of biomaterials in tissue repair. This concrete interaction occurs via cells and bioactive substances, such as proteins and nucleic acids. These cell...
Article
Full-text available
Lung cancer is the leading cause of cancer-related death worldwide. Cancer immunotherapy has shown great success in treating advanced-stage lung cancer but has yet been used to treat early-stage lung cancer, mostly due to lack of understanding of the tumor immune microenvironment in early-stage lung cancer. The immune system could both constrain an...
Article
Full-text available
Esophageal stricture commonly occurs in patients that have suffered from endoscopic submucosal dissection (ESD), and it makes swallowing difficult for patients, significantly reducing their life qualities. So far, the prevention strategies applied in clinical practice for post-ESD esophageal stricture usually bring various inevitable complications,...
Article
Functional nanomaterials such as iron oxide nanoparticles have been extensively explored for the diagnosis and treatment of central nervous system diseases. However, an insufficient understanding of the comprehensive nanomaterial-biological interactions in the brain hinders the nanomaterials from meeting the medical requirements for translational r...
Article
Full-text available
Ferroptosis is a new type of programmed cell death, which is expected to become an important strategy of cancer treatment. Traditional strategies for inducing iron death are small molecule inducers based on biological agents. However, because of their poor water solubility, low cell targeting ability and fast metabolism in vivo, it is difficult for...
Article
Smart hydrogels which can respond to external stimuli have been widely focused with increasing interest. Thereinto, magnetic-responsive hydrogels that are prepared by embedding magnetic nanomaterials into hydrogel networks are more advantageous in biomedical applications due to their rapid magnetic response, precisely temporal and spatial control a...
Article
OBJECTIVES To investigate the impact of lung window (LW) and mediastinal window (MW) settings on the clinical T classifications and prognostic prediction of patients with subsolid nodules. METHODS Seven hundred and nineteen surgically resected subsolid nodules were reviewed, grouping into pure ground-glass nodules (n = 179) or part-solid nodules (...
Article
Full-text available
New‐era soft microrobots for biomedical applications need to mimic the essential structures and collective functions of creatures from nature. Biocompatible interfaces, intelligent functionalities, and precise locomotion control in a collective manner are the key parameters to design soft microrobots for the complex bio‐environment. In this work, a...
Article
Full-text available
Reactive oxygen species (ROS), a group of oxygen derived radicals and derivatives, can induce cancer cell death via elevated oxidative stress. A spatiotemporal approach with safe and deep‐tissue penetration capabilities to elevate the intracellular ROS level is highly desirable for precise cancer treatment. Here, a mechanical‐thermal induction ther...
Article
Background: Our objective in this paper is to introduce a new method for handling calcified hilar lymph nodes during lobectomies by video-assisted thoracoscopy that effectively avoids arterial injury and possible conversions. Methods: The 12 cases in this study were initially evaluated as eligible and were subsequently scheduled for thoracoscopi...

Citations

... Despite these advances, lung cancer continues to pose a significant public burden that is heightened by its dismal overall prognosis, poor clinical outcome, and a five-year survival rate of only 18% in the US, which is among the lowest across early-stage malignancies [13]. These sub-optimal outcomes are attributed to multiple factors, including low screening adherence (4-6% of potential eligible candidates in the United States) [14] as well as resistance of certain of patient subgroups to specific treatment strategies [15]. For instance, durable benefits in response to single-agent ICB are limited to a subset of patients, and this setback highlighted an urgent need to better identify biomarkers to stratify patients who are likely to respond to ICB and to determine the best window of time for therapeutic intervention [16]. ...
... Intracerebral neurotoxicity and metabolic pathways of inorganic nanoparticles are hot topics in this field. Studies revealed that up to 90% of intratumorally injected IONPs are recognized and phagocytosed by tumorassociated microglia and macrophages (Feng, Xu, et al., 2021). Extracellular vesicle-encapsulated nanoparticles could be gradually eliminated from the brain with cerebrospinal fluid circulation within 21 days and showed no apparent neurotoxicity. ...
... However, due to either the aggregation of high content magnetic nanoparticles or relatively complex in situ precipitation process, magnetic nanoparticles fail to be easily integrated with the existing preparation methods, enabling most magnetic hydrogels weak and brittle. The mechanical weakness, particularly the trade-off between tensile strength and toughness, thus confines them to only utilize in the fields, such as heavy metal adsorption, drug delivery and enzyme immobilization [4][5][6]. It is highly desirable to develop an effective strategy to synthesize strong and tough magnetic hydrogels to enlarge their applications. ...
... For example, Malfa et al. found that an extract of Betula aetnensis Rafin can upregulate the expression of heme oxygenase-1 (HO-1), induce ferroptosis, and result in cell death in Caco2 cell lines [8]. In addition, Li et al. applied iron-based nanomaterials to tumor therapy for a better induction effect of ferroptosis and a more efficient anticancer condition [9]. In CC, a biocompatible fusiform iron oxide-hydroxide nanospindle (FeOOH NSs) nanosystem was created by Li et al. for specific treatment, as it causes cell death via ferroptosis [10]. ...
... In tortuous distal vascular regions, these devices need to achieve shape adaption for changing lumen diameters, withstand the flow even if the external actuation is disrupted or turned off (i.e., self-anchoring capability) for safe local operations, traverse among curved routes and bifurcations, and be movable against the blood flow for retrieval or mistaken navigation. However, all the previous works have shown limitations in concurrently fulfilling all of these requirements [18][19][20][21][22][23][24][25][26][27] . Notably, most of the previous designs lack the self-anchoring capability with the surrounding lumen and could be drifted away by the pulsatile flow. ...
... During the circulation in vitro, the blood is subjected to a rotational magnetic field. Based on the above-mentioned cases, the rotational magnetic field will actuate the magnetic nanochains to rupture the organelles including the lysosomes and the cytoskeletons so that the cellular environment turns acidic, facilitating the release of DOX and the apoptosis of cancerous cells [34][35][36][37]. Moreover, another advantage of this strategy is that the magnetic assembly is facile to get prompt separation. ...
... (ii) During dissection, it is mandatory to expose the target PA by more than two thirds of its circumference in order to close the entire vessel with a proximal and distal suture as also reported in other series. 8, 11 (iii) The needle should be passed across the nodes and not across the vessels to avoid vascular injury. Our procedure is indicated in selected cases such as patients with calcified or inflammatory LNs between the target PA and the bronchial tree. ...