Yifei Wang's research while affiliated with Jiangsu University and other places

Publications (2)

Article
Full-text available
Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the course of the development of fibrosis, certain parts of the intestine become narrowed, significantly destroying the structure and function of the intestine and affecting the quality of life of patients. Chronic inflammation is an important initiating factor...
Article
Full-text available
Gut mucosal barriers, including chemical and physical barriers, spatially separate the gut microbiota from the host immune system to prevent unwanted immune responses that could lead to intestinal inflammation. In inflam-matory bowel disease (IBD), there is mucosal barrier dysfunction coupled with immune dysregulation and dysbio-sis. The discovery...

Citations

... However, most evidence indicates that gastrointestinal tract fibrosis occurs only in previously or actively inflamed regions, implying that persisting inflammation is a necessary condition for developing fibrosis. In physiological conditions, acute inflammation is normally followed by healing with tissue restoration and functional recovery; in pathological conditions, the fibrotic process is established by the persistence of the inflammatory stimulus [4][5][6][7][8][9]. Many studies have demonstrated that TGF-β stimulates the activation and proliferation of fibroblasts, resulting in extracellular matrix deposition and fibrosis in several organs, including lungs, kidneys, liver, skin, and gut [9][10][11][12][13][14]. Actually, inflammation causes the release of TGFβ, with the consequent activation of fibroblasts that differentiate into myofibroblasts, a cell type that has an intermediate phenotype between smooth muscle cells and fibroblasts. ...
... Monitoring these changes to guide clinical diagnosis and treatment will help physicians understand the conditions of patients and adjust their diagnosis and treatment plan in time. Therefore, exosomes are becoming a new tool to gain specific information of diseases; moreover, they can serve as biomarkers for pathophysiology [23,24]. In summary, studies have shown the potential of exosomes for multiple applications in the treatment of pancreatic diseases. ...