Yelena Fishman's research while affiliated with Max Planck Institute for Developmental Biology and other places

Publications (3)

Article
The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to minute quantities of GABAA receptor agonists, induces a state of general anesthesia. In addition to immobility and analgesia this state is accompanied by widespread suppression of neural activity in the cerebral cortex and high delta-band power in th...
Article
The MPTA (mesopontine tegmental anesthesia area) is a key node in a network of axonal pathways that collectively engage the key components of general anesthesia: immobility and atonia, analgesia, amnesia and loss-of-consciousness. In this study we have applied double retrograde tracing to analyze MPTA connectivity, with a focus on axon collateraliz...
Article
General anesthetic agents induce loss of consciousness coupled with suppression of movement, analgesia and amnesia. Although these diverse functions are mediated by neural structures located in wide-ranging parts of the neuraxis, anesthesia can be induced rapidly and reversibly by bilateral microinjection of minute quantities of GABAA -R agonists a...

Citations

... The parameter measured is postponement of emergence, rather than anesthetic induction per se. However, we have previously documented in rats that pro-anesthetic effects, specifically frank induction of anesthesia, is observed when GABAergic drugs are delivered to the MPTA while the animal is in the awake state (Devor and Zalkind 2001;Devor et al. 2016;Avigdor et al. 2021). Sequentially altering experimental parameters from one protocol to the next improved our ability to detect significant bonus times. ...