Yao Lu's research while affiliated with University of Twente and other places

Publications (16)

Article
Due to their easy, fast, and noninvasive natures, acoustic wave methods have been widely used in the physical property measurements of liquids, such as shear waves for viscosity and ultrasound for density. We investigate the physical interaction between approximately GHz longitudinal acoustic waves and simple Newtonian fluids in micro- and nanoscal...
Article
Full-text available
Rapid and reliable micromixing requires continuous improvement to renovate more powerful microfluidics chip for chemosynthesis, biological assay, and drug purification. In this work, we realized rapid in-situ mixing in droplets on a closed electro-microfluidic chip. Electrowetting and 2.5 GHz acoustic wave streaming were coupled into a monolithic c...
Article
Full-text available
Controllable exchange of molecules between the interior and the external environment of vesicles is critical in drug delivery and micro/nano‐reactors. While many approaches exist to trigger release from vesicles, controlled loading remains a challenge. Here, we show that gigahertz acoustic streaming generated by a nanoelectromechanical resonator ca...
Article
For point-of-care applications, integrating sensors into a microfluidic chip is a nontrivial task, since conventional detection modules are bulky and microfluidic chips are small in size, and their fabrication processes are not compatible. In this work, a solid-state microfluidic chip with on-chip acoustic sensors using standard thin-film technolog...
Article
In article number 1602962, Xuexin Duan and co-workers, explore a novel chemical-free cell poration method – “hypersonic poration”, which is developed to improve the cellular uptake, especially nucleus uptake, using a designed piezoelectric nanoelectromechanical resonator. The hypersound has a typical frequency larger than GHz, which can directly in...

Citations

... Body fluids such as blood or urine are an attractive source of information for disease detection [1][2][3][4], and one of the techniques for track their condition is by monitoring their mechanical properties [5][6][7], among which are its compressional properties. Compressional information is an interesting parameter in analysis since, at microscales, it is closely related to the chemical bond strength between atoms, ions, or molecules, and therefore can be used in analyzing human physiological fluids [8,9]. For instance a change in the mechanical properties of blood can be potentially related with cardiovascular dysfunctions, providing a fast and simple method for rapid and early test of a possible disease as it is already explained in reference [5]. ...
... To enhance the mixing, different types of active and passive methods are designed. Active methods need to exert an external field, such as magnetic (Kang et al. 2007), electronic (Mugele et al. 2006), and acoustic (Lu et al. 2018) for operation, and a more complicated device design is required. While passive methods, such as, altering the straight channel into a serpentine channel (Liu et al. 2000) and using asymmetric design of channels (Belousov et al. 2021), are all supposed to geometrically induce advection inside the droplet to enhance the mixing. ...
... However, current exosome isolation technologies have low yields and can damage exosomes, resulting in a loss of biomarkers 18 . Furthermore, conventional ultracentrifugation and affinity capture take a long time (several hours to several days), which limits their use in point-of-care settings [19][20][21][22] . As a result, with most current exosome isolation technologies, it is not suitable to use exosomes as point-of-care biomarkers for TBI screening and diagnosis. ...