Yang Liu’s research while affiliated with Henan University of Technology and other places

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Publications (63)


Identification of PLK1 as the Target of Tubocapsenolide A for the Activation of Colorectal Cancer Ferroptosis by PROTAC Technology
  • Preprint

October 2024

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8 Reads

Yueying Yang

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Yang Liu

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Lu Wang

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[...]

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Lixia Chen

Drug resistance seriously affects the treatment effect and survival rate of colorectal cancer (CRC) patients. The discovery of novel drugs and mechanisms is an important way to overcome drug resistance. Here, Tubocapsenolide A (TA), a major withanolide isolated from Tubocapsicum anomalum, significantly inhibited the growth of patient-derived organoids with oxaliplatin or 5-fluorouracil resistance and HCT116-/DLD-1-derived xenografts. Leveraging Proteolysis Targeting Chimera (PROTAC)-based target identification approach, PLK1 was identified as a direct target of TA. Mechanistically, PLK1 was first determined as a p53 cytoplasmic anchoring factor to prevent p53 from inducing ferroptosis in CRC. TA competitively inhibits the formation of PLK1-p53 heterodimers, promotes the nuclear translocation of p53, and then activates ferroptosis. Collectively, our study clarified the key role of PLK1 in p53-mediated ferroptosis for the first time and elucidated a novel mechanism of TA as a natural ferroptosis inducer in CRC treatment. The activation of the PLK1-p53-ferroptosis signaling axis may provide a brand-new strategy for the treatment of CRC.


The overall architecture of the Serein algorithm.
The flowchart of the Serein algorithm.
Parallel pipeline architecture of the Serein algorithm.
The DAG structure in a real‐world network environment.
The final DAG structure.

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Serein: A parallel pipeline‐based DAG schema for consensus in blockchain
  • Article
  • Full-text available

August 2024

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25 Reads

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1 Citation

As the core technology of blockchain, consensus mechanisms play a crucial role in ensuring the consistency and reliability of blockchain systems. In a decentralized and open system environment like blockchain, traditional consensus algorithms are often unsuitable due to their inability to tolerate arbitrary faults such as malicious node behaviour. Consequently, Byzantine fault tolerance consensus algorithms have become a focal point in blockchain systems. However, as Byzantine fault tolerance consensus algorithms have evolved, they still face significant challenges, particularly in addressing issues related to network latency and throughput. This paper proposes a parallel pipeline‐based DAG schema for consensus in blockchain, Serein. Firstly, the Serein algorithm achieves functional partitioning of nodes, enhancing their scalability. Secondly, it employs a pipeline structure, allowing each block to proceed without waiting for the previous block's result, thereby reducing block generation latency. Lastly, the Serein algorithm leverages the advantages of the DAG block structure to achieve concurrent block ordering and submission, improving system throughput. Experimental results demonstrate that the proposed Serein algorithm maintains robust performance under conditions of high transaction volume with multiple nodes, effectively enhancing consensus efficiency while ensuring Byzantine fault‐tolerant security.

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Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines

July 2024

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30 Reads

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1 Citation

Medicines

Cytokine storm (CS) is the main driver of SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) in severe coronavirus disease-19 (COVID-19). The pathological mechanisms of CS are quite complex and involve multiple critical molecular targets that turn self-limited and mild COVID-19 into a severe and life-threatening concern. At present, vaccines are strongly recommended as safe and effective treatments for preventing serious illness or death from COVID-19. However, effective treatment options are still lacking for people who are at the most risk or hospitalized with severe disease. Chinese herbal medicines have been shown to improve the clinical outcomes of mild to severe COVID-19 as an adjunct therapy, particular preventing the development of mild to severe ARDS. This review illustrates in detail the pathogenesis of CS-involved ARDS and its associated key molecular targets, cytokines and signalling pathways. The therapeutic targets were identified particularly in relation to the turning points of the development of COVID-19, from mild symptoms to severe ARDS. Preclinical and clinical studies were reviewed for the effects of Chinese herbal medicines together with conventional therapies in reducing ARDS symptoms and addressing critical therapeutic targets associated with CS. Multiple herbal formulations, herbal extracts and single bioactive phytochemicals with or without conventional therapies demonstrated strong anti-CS effects through multiple mechanisms. However, evidence from larger, well-designed clinical trials is lacking and their detailed mechanisms of action are yet to be well elucidated. More research is warranted to further evaluate the therapeutic value of Chinese herbal medicine for CS in COVID-19-induced ARDS.


Flow diagram of retrieved journal articles.
Schematic of the influence of curcumin on mammalian DHA synthesis pathway and its neuroprotective effect [61]. ALA: alpha-linolenic acid; DPA: docosapentaenoic acid; FADS2: fatty acid desaturase 2; Elov: elongase; BDNF: Brain-derived neurotrophic factor; TrkB: tropomyosin receptor kinase B; NF-κB: nuclear factor-kappa B; IL-6: interleukin-6; TNF: tumor necrosis factor; and iNOS: inducible nitric oxide synthase.
Clinical studies of FO and natural product combinations in improving or protecting cognitive function.
Cont.
Combination Therapy for Sustainable Fish Oil Products: Improving Cognitive Function with n-3 PUFA and Natural Ingredients

Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are recommended as beneficial dietary supplements for enhancing cognitive function. Although fish oil (FO) is renowned for its abundant n-3 PUFA content, combining FO with other natural products is considered as a viable option to support the sustainable development of FO products. This review aims to provide comprehensive insights into the advanced effects of combining FO or its components of DHA and EPA with natural products on protecting cognitive function. In two double-blind random control trials, no advanced effects were observed for adding curcumin to FO on cerebral function protection. However, 16 week’s treatment of FO combined with vitamin E did not yield any advanced effects in cognitive factor scores. Several preclinical studies have demonstrated that combinations of FO with natural products can exhibit advanced effects in addressing pathological components in cognitive impairment, including neuroinflammation, oxidative stress, and neuronal survival. In conclusion, evidence from clinical trials for beneficial use of FO and natural ingredients combination is lacking. Greater cohesion is needed between preclinical and clinical data to substantiate the efficacy of FO and natural product combinations in preventing or slowing the progression of cognitive decline.




Security mechanism design requirements in blockchain-6G Network
The round-based DAG structure
The architecture of the consensus protocol
Performance of the protocol with different number of shards and different input rates
(Data presented in S1 and S2 Tables in S1 File).
Comparative analysis of traditional consensus protocols and DAG consensus protocols
Towards secure and efficient integration of blockchain and 6G networks

April 2024

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129 Reads

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6 Citations

The future of communication systems is undergoing a transformative shift towards intelligence, efficiency, and flexibility. Presently, the amalgamation of blockchain technology and the sixth-generation mobile communication network (6G) has garnered significant attention, as their fusion is poised to profoundly impact the digital economy and society at large. However, the convergence of blockchain and 6G networks poses challenges pertaining to security and performance. In this article, we propose an approach based on the design of secure mechanisms and performance optimization to delve into the key issues surrounding the integration of blockchain and 6G networks from both security and performance perspectives. Specifically, we first introduce the application scenarios of 6G networks and blockchain’s empowerment of them to highlight the necessity of combining blockchain technology with 6G. Subsequently, in order to ensure the security of communication and data transmission between blockchain and 6G networks, we have investigated the design requirements for security mechanisms. Furthermore, we discuss the efficient realization of the amalgamation between blockchain and 6G networks by proposing a solution based on Directed Acyclic Graph (DAG) for blockchain’s asynchronous consensus protocol, alongside optimization strategies for storage and communication to meet the desired characteristics and requirements of 6G networks. Lastly, we provide valuable research directions that serve as references and guidance for the future development of the integration between blockchain and 6G networks.



Citations (41)


... Significantly, PTX-loaded IF-7-MNC (IF-7-PMNC) displayed potent tumor suppression, increasing the inhibitory rate to 89% compared to plain nanoparticles (PMNC) [32]. The process of identifying and validating targets can be effectively carried out using PROTAC technology [155,156]. The transmembrane protein programmed cell death protein 1 (PD-1) and its ligand (PD-L1) play a crucial role in cancer immunotherapy. ...

Reference:

Peptide Aptamer–Paclitaxel Conjugates for Tumor Targeted Therapy
Application of PROTACs in Target Identification and Target Validation
  • Citing Article
  • March 2024

Acta Materia Medica

... Serein [100] introduces a parallel pipeline-based directed acyclic graph (DAG) schema to improve the efficiency of consensus in blockchain systems. The parallel pipeline architecture ensures that multiple drone transactions can be processed concurrently, enabling real-time coordination between drones without delays caused by waiting for consensus from previous transactions. ...

Serein: A parallel pipeline‐based DAG schema for consensus in blockchain

... For example, in blockchain-based real estate, a smart contract replaces brokers, verifying ownership and payment through decentralized consensus. Therefore, it reduces costs and mitigating fraud risks [43,44]. Because of this advantage, smart contracts have been actively utilized in various blockchain service industries, such as identification, supply chain, energy, and IoT. ...

An overview of blockchain smart contract execution mechanism
  • Citing Article
  • August 2024

Journal of Industrial Information Integration

... If the number of consensus failures in the consensus cycle τ exceeds α0, a view change is triggered immediately. Otherwise, the view changes at the end of τ by reselecting the consensus nodes and the primary node (lines [37][38][39][40][41]. Compared to traditional PBFT consensus algorithms, AP-PBFT reduces the number of view changes while ensuring network availability, thereby lowering the communication and computational overhead of the network. ...

TortoiseBFT: An asynchronous consensus algorithm for IoT system
  • Citing Article
  • June 2024

Journal of King Saud University - Computer and Information Sciences

... Of the estimated 250,000 higher plants, less than 1% have been screened pharmacologically, and even fewer have been screened for DM (Arumugam et al., 2013). Lamentably, the traditional medicinal herbs used to treat DM have not been studied in toto (Fei et al., 2024). ...

Natural products with potential hypoglycemic activity in T2DM: 2019-2023
  • Citing Article
  • May 2024

Phytochemistry

... -Instant Payments: Smart contracts ensure immediate payment upon service completion. -Financial Inclusion: Cryptocurrencies allow unbanked populations to engage in the global tourism economy without needing traditional financial infrastructure (Liu et al., 2024). ...

Towards secure and efficient integration of blockchain and 6G networks

... The Petrichor protocol [101], same as Komorebi [102], employs a DAG structure within shards to leverage parallel transaction processing. It introduces a leader block election mechanism to facilitate fast consensus within each shard, significantly improving performance. ...

Petrichor: An Efficient Consensus Protocol Leveraging DAG and Sharding for Asynchronous BFT
  • Citing Chapter
  • November 2023

Communications in Computer and Information Science

... In this context, withanolides, a class of secondary metabolites extracted from different plants, have been the subject of great interest not only because of their anti-inflammatory (Abdeljebbar et al., 2009), anxiolytic (Bhattacharya et al., 2000), cytotoxic (Paul et al., 2021), but especially anticancer (Zhang et al., 2023;WalyEldeen et al., 2023) properties, both in vivo and in vitro (Kumar et al., 2010;Guerreiro et al., 2019;Zhao et al., 2021). Withanolide derivatives trigger apoptosis in cancer cells by activating both the intrinsic and extrinsic pathways of programmed cell death (Samadi, 2015). ...

Molecular targets and mechanisms of anti-cancer effects of withanolides
  • Citing Article
  • September 2023

Chemico-Biological Interactions

... The Petrichor protocol [101], same as Komorebi [102], employs a DAG structure within shards to leverage parallel transaction processing. It introduces a leader block election mechanism to facilitate fast consensus within each shard, significantly improving performance. ...

Komorebi: A DAG-based Asynchronous BFT Consensus via Sharding
  • Citing Conference Paper
  • July 2023

... A recent study demonstrated that targeting EED in this way led to the degradation not only of EED but also of EZH2 and an additional PRC2 component, SUZ12 (36). Importantly, another recent study demonstrated that EZH2-targeting PROTACs (in which tazemetostat is linked to an E3 ligand) acted similarly, leading to the degradation not only of EZH2 but also of EED and SUZ12 (37). ...

Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma
  • Citing Article
  • August 2023

Bioorganic Chemistry