Yanan Zhu's research while affiliated with Zhejiang University and other places
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Publications (42)
Purpose:
To investigate the visual quality after femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) with the implantation of an extended depth-of-focus (EDOF) intraocular lens (IOL) TECNIS Symfony.
Setting:
Eye Center, the Second Affiliated Hospital of Zhejiang University, Zhejiang, China.
Des...
Purpose
To compare the internal aberrations and optical quality after femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification cataract surgery (CPCS).
Methods
This study included patients who received FLACS or CPCS from January 2016 to July 2019. Postoperative examinations included wavefront measurements under pupi...
Background
Presbyopia has become a global disease affecting the world's aging population. Among various treatments, cataract extraction and intraocular lens (IOL) implantation have become the most popular and common methods of presbyopia correction. During the twentieth century, IOLs have underwent significant innovation and advancements to meet th...
Purpose:
To compare anterior capsule contraction of two kinds of hydrophilic and hydrophobic acrylic intraocular lenses (IOLs) under the same size capsulotomy with femtosecond laser-assisted cataract surgery (FLACS).
Methods:
A total of 320 eyes in 320 patients who underwent FLACS were included. The patients were scheduled to have hydrophilic ac...
Background: Among the various intraocular lens (IOL) power calculation formulas available in clinical settings, which one can yield more accurate results is still inconclusive. We performed a meta-analysis to compare the accuracy of the IOL power calculation formulas used for pediatric cataract patients.
Methods: Observational cohort studies publis...
Introduction
With the accumulating evidence of ocular manifestations of the 2019 novel coronavirus disease (COVID-19), the study aimed to systematically summarize ocular manifestations in COVID-19 patients.
Methods
The PubMed, EMBASE, Web of Science databases were searched from through June 2021. Studies that provided clinical characteristics and...
Purpose
Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied in previous observational studies, the precise manner in which one or more n-6 PUFAs account for this relationship remains unclear. Using genetic instruments for n-6 PUFAs traits implemented through mendelian randomization...
Purpose: To compare the parameters of capsulorrhexis and intraocular lens decentration after femtosecond laser capsulotomy and manual continuous curvilinear capsulorrhexis in high myopic patients with cataracts.
Methods: This is a prospective consecutive non-randomized comparative cohort study. Selected patients with axial length > 26.0 mm were div...
Background:
Femtosecond laser assisted cataract surgery (FLACS) combined with implantable collamer lenses (ICLs) extraction has been shown to be a feasible method for patients developing cataracts after the ICL implantation. All reported cases had shallow vaults, ranging from 47 μm (μm) to 100 μm. We report for the first time, a case in which the...
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Fibrosis is a result of the pathological wound‐healing response initiated by immune cells and leads to permanent scarring, such as corneal scarring, which impairs the vision of millions of people worldwide. However, there is currently no available treatment strategy that specifically targets the pathogenesis of fibrosis and can be translated in a s...
Purpose:
To compare the visual outcomes and optical quality of 2 presbyopia-correcting intraocular lenses (IOLs) with those of a monofocal IOL.
Settings:
Eye Center, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Design:
Prospective, nonrandomized, examiner-blinded cohort study.
Method:...
Purpose:
To compare the perioperative parameters of quadrant, sextant, and grid lens fragmentation patterns in femtosecond laser-assisted cataract surgery (FLACS).
Design:
Prospective randomized clinical trial.
Methods:
.
Setting:
Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Patient...
Purpose:
To compare the clinical outcomes of echelette extended range of vision (ERV) and diffractive bifocal intraocular lenses (IOLs).
Methods:
This is a prospective, consecutive, nonrandomized clinical trial. Seventy-three eligible patients (109 eyes) received the implantation of echelette ERV IOL (Tecnis Symfony ZXR00) or diffractive bifocal...
Purpose:
Comparison of lens capsule-related complications resulting from femtosecond laser-assisted capsulotomy and manual capsulorhexis in patients with white cataracts.
Setting:
Eye Center, Second Affiliated Hospital, Zhejiang Medical School, Hangzhou, China.
Design:
Prospective consecutive nonrandomized comparative cohort study.
Methods:...
Background:
We report for the first time, a case of femtosecond laser-assisted cataract surgery (FLACS) with implantation of a diffractive trifocal intraocular lens (IOL) after laser in situ keratomileusis (LASIK).
Case presentation:
A 60-year-old man underwent FLACS uneventfully 15 years after myopic LASIK. An AT Lisa tri 839MP IOL was implante...
Rationale
Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops.
Patient concerns
Two cases admitted to our hospital because of ptosis of their right eye after long-term treatment...
Purpose
To compare the morphologic features and surgically induced astigmatism (SIA) between laser and manual clear corneal incisions (CCIs) after femtosecond laser–assisted cataract surgery.
Setting
Eye Center, 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.
Design
Prospective case series.
Methods
Patients had...
s
Background
Femtosecond laser-assisted cataract surgery (FLACS) has grown in popularity among ophthalmologists as a novel technique. However, descemet membrane detachment (DMD) began to be found as the complication after FLACS. We report a case of serious DMD following FLACS due to the inappropriate incision design.
Case presentation
An 85-year-...
Statement of significance:
The clarity of cornea is important for normal vision. The loss or dysfunction of LESCs leads to the impairment of corneal epithelium. The complete regeneration of corneal epithelium has not been achieved. Our study demonstrated that the incorporation of rhSDF-1 alpha with CHI hydrogel accelerated corneal epithelium recon...
Purpose
To compare the outcomes between femtosecond laser–assisted cataract surgery (femtosecond group) and conventional phacoemulsification cataract surgery (conventional group) in patients with hard nuclear cataract.
Setting
Eye Center, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China.
Design
Prospective co...
To assess the visual effects of trifocal intraocular lenses (IOLs) compared to bifocal IOLs in cataract surgery, a meta-analysis of prospective comparative clinical trials (including 4 randomized controlled trials and 4 cohorts) was conducted. The defocus curves showed a better distance-corrected intermediate visual acuity (VA) for the trifocal gro...
Endophthalmitis can be a devastating complication after cataract surgery. Therefore, this study sought to better understand the occurrence rate of acute-onset postoperative endophthalmitis after cataract surgery in Chinese small and medium-scale departments of ophthalmology, as well as identify its risk factors and assess the treatment options. Thi...
Purpose
To compare dry eye after small incision lenticule extraction (SMILE) and femtosecond laser-assisted LASIK (FS-LASIK) for correcting myopia.
Methods
CENTRAL, Embase and PubMed were searched in November 2016. All randomized controlled trials (RCTs) and prospective cohorts that compared dry eye after SMILE with FS-LASIK were selected.
Result...
PRISMA-checklist in this meta-analysis.
(DOC)
Autosomal dominant congenital cataracts (ADCC) are clinically and genetically heterogeneous diseases. The present study recruited two Chinese families with bilateral nuclear cataract or zonular pulverulent phenotype. Direct sequencing of candidate genes identified two novel missense mutations of Cx50, Cx50P59A (c.175C > G) and Cx50R76H (c.227G > A)...
To investigate the molecular defects in a four-generation Chinese pedigree affected with Thiel-Behnke corneal dystrophy (TBCD). And to further study the relationship between genetic mutation and clinical manifestations.
Individuals of the pedigree were recruited for extensive ophthalmic examinations. Histological studies of two corneal buttons obta...
To examine the mechanism by which a novel connexin 50 (Cx50) mutation, Cx50 V44A, in a Chinese family causes suture-sparing autosomal dominant congenital nuclear cataracts.
Family history and clinical data were recorded and direct gene sequencing was used to identify the disease-causing mutation. The Cx50 gene was cloned from a human lens cDNA libr...
The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a member of the water-transporting aquaporin family, which plays a critical role in the maintenance of lifelong lens transparency. To date, several mutations in MIP (OMIM 154050) have been linked to hereditary cataracts in humans. However, more pathogenic mutations remain to be...
Objective:
The goal of this study was to characterize the disease-causing mutations in a Chinese family with congenital nuclear and posterior polar cataracts.
Methods:
Clinical data of patients in the family were recorded using slit-lamp photography and high definition video. Genomic DNA samples were extracted from the peripheral blood of the pe...
To estimate the cumulative incidence of postoperative endophthalmitis, identify risk factors and determine clinical outcomes in China.
Medical records were reviewed for all patients with acute-onset endophthalmitis after cataract surgery from January 2006 to December 2011 at eight eye centres of tertiary care hospitals in China.
Sixty-six cases of...
To characterize the disease-causing mutations in four generations of a Chinese family affected with bilateral congenital nuclear and zonular pulverulent cataract.
Detailed family history and clinical data were recorded. The phenotype was documented using slit-lamp photography. Candidate genes were amplified using PCR and screened for mutations usin...
Aniridia is phenotyically and genetically heterogeneous. This study is to summarize the phenotypes and identify the genetic defect responsible for aniridia and congenital progressive cataract in a three generation Chinese family.
A detailed family history and clinical data from patients were collected by ophthalmologic examination, including visual...
Congenital cataract (CC) is the leading cause of visual disability in children. To date, mutations in many genes have been linked to CC. In a four-generation Chinese family with congenital nuclear pulverulent and posterior polar cataracts, we detected a heterozygous c.5G>A transition in the second exon of GJA3, resulting in the substitution of a hi...
A 50-year-old man suffering from hypotony in the right eye caused by a traumatic cyclodialysis and complicated by a choroidal detachment and cataract was treated in our clinic. After an unsuccessful direct cyclopexy, phacoemulsification was performed and a normal-sized single-piece polymethyl methacrylate posterior chamber intraocular lens (PMMA PC...
To report the clinical and molecular features of a distinct form of transforming growth factor-β-induced (TGFBI) gene-linked corneal dystrophy exhibiting a new granular corneal dystrophy type I (CDGG1) phenotype.
A complete ophthalmologic examination was performed in all individuals of a Chinese family in which autosomal dominant transmission of th...
To identify the underlying genetic defect in four generations of a Chinese family affected with bilateral congenital posterior subcapsular cataracts.
Clinical data from patients in the family were recorded by slit-lamp photography. Genomic DNA samples were extracted from peripheral blood of the pedigree members. Mutation screening was performed in...
To characterize the disease-causing mutations in a Chinese family with progressive childhood cataracts.
Family history and clinical data were recorded. Direct gene sequencing together with multi-point linkage analysis using microsatellite markers flanking the gene was applied to identify the disease-causing mutation.
Lens examination in the affecte...
To detect the underlying genetic defect in a Chinese family affected with bilateral congenital cataracts.
A detailed family history and clinical data were recorded. Mutation screening was performed in the nuclear cataract-related gene by bidirectional sequencing of the amplified products. The mutation was verified by denaturing high-performance liq...
Citations
... Therefore, one possible explanation for these results was the application of FLACS. Xu et al [39] reported that FLACS presented a significantly lower total HOAs and spherical aberration, because femtosecond laser was able to accurately control the size and shape of the capsulotomy and deliver a more centered IOL, resulting in lower internal HOAs and higher visual quality in comparison with conventional phacoemulsification. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/977247649427461-1610005404380_Q64/Jia-Xu-55.jpg)
... For example, one study reported that hydrophobic IOLs induced greater postoperative inflammation and more ACC, which was included in the secondary complications of capsular contraction syndrome (CCS) [14]. But the latest findings implied that with the same size capsulotomy with femtosecond laser-assisted cataract surgery (FLACS), the hydrophobic IOLs induced less anterior capsule contraction than hydrophilic IOLs [18]. Correspondingly, scientists hold various opinions upon haptic designs in terms of ACC [19,20]. ...
... The measurement of ocular biometric parameters is an essential aspect of ophthalmic practice. In addition, determining the means and ranges of the ocular parameters at different ages and gender can help establish reference values and guide the diagnosis of ocular diseases [1][2][3][4][5][6][7][8]. However, since ocular biometric parameters differ by age, gender, and geographic region [9][10][11], there is a need to determine the means and distributions of these parameters among different age groups within a population. ...
... The book Ophthalmic Manifestations Of Coronavirus claims that 2-32% of patients with COVID-19 present ocular symptoms (9). SARS-CoV-2 infection can affect anatomical eye sites such as the anterior and posterior segments, appendages, and nerves, and it can lead to such common symptoms as conjunctivitis and to rare ones such as retinal arteriovenous obstruction, optic neuritis, uveitis, and orbital lesions (10)(11)(12). A meta-analysis of 43 studies with 10,572 participants showed that patients with COVID-19 had a high prevalence of conjunctivitis, ptosis, ophthalmoplegia, cotton wool spots, retinal hemorrhages, and retinal vein tortuosity (13). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/736345555222529-1552569869290_Q64/Kai-Wang-326.jpg)
... Also, cataract is the main cause of blindness worldwide and surgery for its correction is the most performed surgical procedure in the world, with some an estimated 19 million surgeries per year [3]. However, this number is expected to come increasing, as a result of the increasing size of the population, the increase in average life expectancy, the increase in chronic diseases associated with aging, such as diabetes mellitus, and the development of expectations regarding health [4][5][6][7]. ...
... Additionally, a study by Fu et al. [56] showed that a diet rich in FAw6 accelerated the maturation process of retinal neurons while inducing increased metabolism to maintain the energy balance of retinal neurons. A study conducted by Kai Wang et al. [57] revealed that LA plays a significant role in the negative correlation between FAw6 and susceptibility to age-related macular degeneration. The controversy surrounding FAw6 may arise from the differential roles of LA and AA in the eye. ...
... In contrast, when the AL is more than 26 mm or the refraction is greater than −6.00D, this is called high myopia [65]. Cataract patients with high myopia always present with nuclear cataract and capsular bag relaxation [66,67]. ...
... Описано, что непрерывная репликация вируса в конъюнктиве может сохраняться даже дольше, чем в носоглотке (более 20 дней) [16]. Вместе с тем вирусная нагрузка в конъюнктивальном мешке нестабильна и относительно низка, чувствительность выявления COVID-19 при исследовании конъюнктивы составляет 2-7 % [17]. ...
... It has been reported that when using a femtosecond laser to perform cataract surgery after an ICL procedure, the laser device may mistake the ICL for its lens when scanning after stabilizing the eyeball, necessitating manual adjustment [17]. The air bubbles produced during the anterior capsule's cutting accumulate under the ICL after laser emission, affecting both the femtosecond laser's ability to cut the lens and the anterior capsule [18,19]. And, if the resulting bubbles accumulate excessively and are unable to enter the anterior chamber due to the ICL obstruction, they can only be pushed backwards, which may damage the suspensory ligament. ...
... Compared with former generations of presbyopia-correcting IOLs, modern diffractive bifocal, trifocal, and EDOF IOLs have shown beneficial effects on spectacle independence and patient satisfaction. 15,[27][28][29] Monovision with monofocal IOLs, which can provide some level of presbyopia correction, has limitations, however, with some patients showing low tolerance due to reduced binocularity and stereopsis, especially with traditional monovision, and relatively low and unsustainable spectacle independence. [30][31][32][33][34] The relatively high usage of monovision with monofocal IOLs in the present study and the relatively low adoption rate of presbyopia-correcting IOLs throughout the study period were somewhat surprising. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/402491490488321-1472972857231_Q64/Xin-Liu-120.jpg)
