Yakham Mohamed Leye’s research while affiliated with Centre Hospitalier Universitaire de Dakar and other places

... Hypertension was the most frequent presenting symptom (48.8%), a pattern observed in LMICs where functional adrenal tumors like pheochromocytomas are more prevalent [9]. In contrast, incidentaloma are more commonly detected in high-income countries, particularly in females during the sixth and seventh decades [10]. ...

Reference:

Clinical Outcomes of Adrenalectomy in a Resource- Limited Setting: Predictors of Complications and Surgical Challenges

... In clinical practice, inadequate control of hyperthyroidism is often the result of suboptimal adherence to ATDs. True ATD resistance as the cause of inadequate control of hyperthyroidism is rare and largely limited to case reports (25). There is no clear definition of ATD resistance, but reports have suggested that this diagnosis can be made in patients whose thyroid hormone levels remain elevated despite compliance to high doses of ATD (26) or when ATD doses exceeding that of standard dose ranges (up to 30mg/day for MMI and 300mg/day for PTU) are required to achieve euthyroidism (27). ...

Reference:

Management of perioperative thyrotoxicosis – what to do when standard therapy is contraindicated or fails?

... 55 However, there are still case reports regarding ATinduced thrombocytopenia. [56][57][58][59] Therefore, a clinical trial will be more convincing and provide further evidence of the therapeutic effects and safety of AT in patients with ITP. ...

Reference:

Atorvastatin restores imbalance of cluster of differentiation 4 (CD4) T cells in immune thrombocytopenia in vivo and in vitro

... 17 Consistent with this finding is the report of previous study in Senegal which reported a male to female ratio of 0.67:1. 18 In this study, majority of the respondents had duration of DM of less than 5 years. The shorter duration of DM seen among the respondents may be due to late presentation to the hospital for early diagnosis and treatment as well as recall bias. ...

Reference:

Assessment of foot care practice among adults with diabetes mellitus in Ogbomoso, Nigeria

... Some are announced, such as skin rash, arthralgia, or even agranulocytosis, However, hepatotoxicity is rarely described. Therefore, during the treatment of Graves' disease, carbimazole drug-induced hepatitis which immutability is likely and probably an immuno-allergic mechanism (Leye et al., 2017a). ...

Reference:

Effect of Carbimazole Drug on Some Adipokines and Gene Expression of TSHR at Different Periods in Hyperthyroid Patients Supervised by

... Sur le plan clinique, le cercle autoaggravant infections-déséquilibre du diabète est bien connu [9]. Abbas et al. rapportaient une glycémie moyenne à 2,8 g/L [8], et l'infection occupait 78 % des facteurs de décompensation diabétique dans la série de Sarr et al. [10]. En l'absence de données d'hémoglobine glyquée (HbA 1c ), la part réelle du déséquilibre glycémique dans la genèse de l'infection reste toutefois difficile à établir dans notre série. ...

Reference:

Caractéristiques cliniques, bactériologiques, et évolutives des infections de la main chez le sujet diabétique. Étude prospective sur 71 cas au Sénégal.

... Ce nom est utilisé pour décrire une métastase cutanée d'une tumeur viscérale à l'ombilic [3]. Son incidence est de 1 à 3 % de tous les néoplasies abdomino-pelviens [4]. Elle pose un problème de diagnostic étiologique, la recherche de la tumeur primitive pouvant se révéler difficile, ainsi qu'un problème de pronostic. ...

Reference:

Sister Mary Joseph’s nodule on ovarian cancer: A case report

... Systematic or targeted screening for GDM is controversial and is reflected in the heterogeneity of international recommendations and professional practices [2,5,7] . The prevalence of GDM and its risk factors depend on the population studied and the screening criteria used [8][9][10] . Thus, the prevalence of GDM is difficult to estimate because of the difficulties of systematic screening and the diversity of diagnostic criteria [4,8,9] . ...

Reference:

Gestational diabetes in urban Guinea: Results of a systematic screening

... Others (three authors) pursued a conservative line of management. While complete resolution was achieved in all cases, the course of 1 patient reported by Touré et al. [5] was complicated by pulmonary embolism. In our case, a trial of medical treatment failed and as the thrombus was free floating and threatening to embolize, we adopted a more aggressive approach. ...

Reference:

Inferior vena caval and right atrial thrombus complicating amoebic liver abscess: Table 1:

... Additionally, the average age of onset diabetic ketoacidosis in the international literature varies between 31 and 45 years and it appears that the second and third decades of life are the most affected by this condition according to research conducted in Morocco [11]. Several international and national studies conducted on diabetic ketoacidosis cases consistently report a female predominance ranging from 51% to 60% [12,13], corroborating with our findings showing that 54.3% of diabetic ketoacidosis cases are females. It is suggested that this higher prevalence among females could be attributed to female hormones which make women more predisposed to diabetes and DKA compared to males. ...

Reference:

Epidemiological profiles of diabetic ketoacidosis at Moulay El Hassan Ben El Mehdi Hospital in Laâyoune, Morocco