January 2015
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The aim of the present study was to formulate, Evaluate and optimize fast dissolving tablets of Glimepiride. Glimepiride is a Third generation sulphonylureas used for the treatment of type-2 diabetes and belongs to BCS class II drugs (Low Solubility and High Permeability). Glimepiride was the drug of choice because of its low dose. Glimepiride fast dissolving tablets (F1- F18) were prepared using super disintegrants like sodium starch Glycolate, Crosscarmelose sodium, Cross povidone by employing direct compression technique. Prepared tablets were evaluated for angle of repose, weight variation, Hardness, % friability, wetting time, drug content, disintegration and in vitro dissolution studies. The results of stability studies revealed no change in physical appearance, drug content and in-vitro dissolution profile, thus indicating that formulations was stable. FTIR studies revealed that there was no significant interaction between drug and polymer in the formulations. Among all the formulations (F1-F18), F-15 was found to be optimized as compared to other formulations.