Y. Li's research while affiliated with Chongqing Cancer Hospital and Institute and other places

Publications (669)

Article
Disulfiram (DSF), which is used to treat alcohol dependence, has been reported to have anticancer effects in various malignant tumors. We studied the anti-cancer effects and mechanism of action of DSF on cervical cancer cell lines HeLa and SiHa. The anti-cancer effects of DSF were confirmed in vivo using a xenograft tumor model. The anti-cancer eff...
Article
Background Structural variations (SVs, defined as DNA variants ≥50 bp) have been associated with various complex human diseases. However, research to screen the whole genome for SVs predisposing to psoriasis is still lacking. Objectives This study aimed to investigate the association of SVs and psoriasis. Methods We performed a genome-wide screen...
Article
Photocatalytic separation membrane has become a research hotspot in wastewater treatment due to its great potential for industrial application. The photocatalytic separation membrane combines membrane separation and photocatalysis in a single unit. Besides playing the role of membrane separation, the photocatalysts can efficiently degrade toxic and...
Article
Background Iguratimod (IGU) has demonstrated efficacy and safety for active rheumatoid arthritis (RA) patients in double-blind clinical trials in China and Japan as a new disease-modifying anti-rheumatic drug (DMARD). There are no studies evaluating the radiographic progression of structural joint damage of IGU for the treatment of RA using the mTS...
Article
Individual identification based on imaging data of the skeleton of a corpse is a key technique for forensic identification. To reduce the influence of artificial factors, computer-aided semi-automatic or automatic individual identification has become one of the research directions of skeleton-based individual identification in forensic radiology. T...
Article
Objective: To investigate the effect of apocynin (Apo) on pressure overload induced cardiac dysfunction in mice and the underlying mechanism. Methods: Forty-eight C57BL/6 male mice were randomly divided into four groups: sham, sham+Apo, TAC, and TAC+Apo. Mice models of pressure overload were constructed by transverse aortic constriction (TAC). Thre...
Article
Background Identifying valid biomarkers for patient selection impressively promotes the success of anti-PD-1 therapy. However, the unmet need for biomarkers in gastrointestinal (GI) cancers remains significant. We aimed to explore the predictive value of the circulating T-cell receptor (TCR) repertoire for clinical outcomes in GI cancers who receiv...
Article
Frontal sinus imaging is an important research object in forensic individual identification due to the highly specific irregular air cavity shape of frontal sinus, the stability of its shape after maturity, and the wide clinical application of radiology technology. The use of frontal sinus imaging for individual identification has significance in t...
Article
Objective To explore the feasibility of the CT image reconstruction of laryngeal cartilage and hyoid bone in adult age estimation using data mining methods. Methods The neck thin slice CT scans of 413 individuals aged 18 to <80 years were collected and divided into test set and train set, randomly. According to grading methods such as TURK et al.,...
Article
Objective: To investigate the preventive and protective effects of salvianolate on isoprenaline (ISO)-induced cardiac hypertrophy in mice. Methods: Cardiac hypertrophy was induced by intraperitoneal injection of ISO. With or without salvianolate, echocardiography was performed to evaluate cardiac function. The heart body weight ratio and lung body...
Article
An intelligent mosquito net employing deep learning has been one of the hotspots in the field of Internet of Things as it can reduce significantly the spread of pathogens carried by mosquitoes, and help people live well in mosquito-infested areas. In this study, we propose an intelligent mosquito net that can produce and transmit data through the I...
Article
Full-text available
Solar irradiance forecasting is one of the most efficient methods to handle the potential problems caused by the large and frequent photovoltaic fluctuations. For the satellite-based forecasting method, the atmospheric attenuation is paid lesser attention than other parts (notably the cloud effects). This study aims to explore the possibility of im...
Article
Background WHO survey showed that the prevalence of anxiety and depression in Chinese population and Chinese patients with chronic diseases were between 3.1% - 4.2% and 3.1% - 7.3%, respectively. SLEDAI-2K and Hospital Anxiety and Depression Scale (HADS) are commonly used to evaluate SLE patients’ disease activity and mental health. All the Assessm...
Article
Background Ankylosing Spondylitis Disease Activity Score (ASDAS) is adopted to evaluate the degree of disease activity and the inflammatory response in AS patients. ASDAS score <= 1.3 represents inactive disease status and achievement of T2T. SSDM is a mobile application for disease management. Objectives To evaluate the patterns of T2T and relate...
Article
The traditional point of view suggests photovoltaic systems to be installed at the optimum angles. However, various reasons require more flexible photovoltaic installations, especially for building-integrated photovoltaics. Some site-specific cases based on local irradiance data show that small deviations from the optimum will not cause big energy...
Article
Aim The objectives of this laboratory‐based study were to investigate the effects of GH12 on Enterococcus faecalis biofilm and virulence. Methodology Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of GH12 against E. faecalis were first determined. A time‐kill assay was further conducted. The effects of GH12 on...
Article
Using acrylamide as monomer, gel-casting was enforced with a mixture of tert-butyl alcohol (TBA) and water as a solvent. The effects of TBA ratio, reaction temperature, the addition of the initiator and catalyst on the gelation time and colloidal form were investigated. The results showed that the gelation time increased with the increase of TBA ra...
Article
Full-text available
By analyzing the formation causes of the mountain torrent disasters as well as the distribution characteristics of rainstorm in Longmen Mountain area, and citing the typical post-seismic the mountain torrent disasters within 2008~2013 after the Wenchuan earthquake in the area as example, the character of post-seismic floods, the spatial distributio...
Article
Background Tislelizumab, an investigational monoclonal antibody with high affinity and specificity for PD-1, was engineered to minimize binding to FcγR on macrophages in order to abrogate antibody-dependent phagocytosis, a mechanism of T-cell clearance and potential resistance to anti-PD-1 therapy. In prior reports, tislelizumab, as a single agent...
Article
Objective: To explore the relationship between hemoglobin (Hb) level during the first trimester of pregnancy and gestational diabetes mellitus (GDM). Methods: A total of 1 276 participants, who underwent scheduled prenatal examination and normal singleton delivery at the Fifth People's Hospital of Shanghai and Hospital of Intergrated Chinese and We...
Article
In order to increase the utilization of solar energy to lower the effect of photovoltaic power output fluctuations on power grids, an adaptive PID control method to improve the power tracking performance of solar photovoltaic air-conditioners is proposed in this paper. In this method, a dynamic temperature set point of the indoor zone is generated...
Article
Background Copy number alterations in cyclin D1 (CCND1) relevant to malignant biological behavior exist in solid tumors, including head and neck squamous cell cancer (HNSCC). The prevalence and utility of CCND1 amplification as a biomarker for the clinical response to immune checkpoint inhibitors (ICIs) therapy is unknown. Methods This was a three...
Article
Background Colorectal cancer (CRC) is one of the most common malignancies worldwide. Investigations revealed that the steep rise of CRC incidence was significantly linked to increased obesity rates. However, the molecular interactions of obesity with CRC are still not well understood. The Notch signaling pathway is critical for many cellular proces...
Article
Background Immune checkpoint inhibitors (ICIs) elicits durable responses in non–small cell lung cancer (NSCLC), but only a fraction of patients responded. TP53 and ATM co-mutation may lead to genomic instability and hypermutation. However, the prevalence and utility of a TP53/ATM co-mutation as a biomarker to ICIs are not fully understood. Methods...
Article
Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by IH exposure. The pathological...
Article
This paper mainly discussed the optimum conditions of hydride generation atomic fluorescence spectrometry (HG-AFS) for the determination of selenium content in eggs, then the analytical method for the determination of selenium content by mixed acid digestion hydride generation atomic fluorescence spectrometry was established, and through testing th...
Article
The intelligent grasping robot can efficiently and reliably perform various handling tasks, reducing the labor intensity of the staff, and accurate object positioning was the basis for the robot to perform the handling task. A robotic grasping system was studied by using Kinect sensor. The robotic grasping system consisted of three subsystems (obje...
Article
Rice blast is a serious disease affecting rice. Four pathogenic genes in rice blast fungi were used to study the molecular pathoge⁃ nicity mechanism of rice blast treated by UV-B radiation. Ultraviolet light to imitate emittances of 0, 2.5 and 5 kJ·m ⁻² to the rice blast and real-time PCR were used to analyze the expression of four pathogenicity-re...
Article
Objective: To investigate nutritional knowledge, attitude, and practice (K-A-P) of medical staff in the nerve-related departments in Hebei province, with the aim of determining a basis for the effective education of nutrition. Methods: A multicenter, observational study was utilized to conduct a questionnaire survey. 642 medical staff in nerve-rela...
Article
Objective: To study the epidemiological characteristics and latent classes of non-marital heterosexual transmission among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) individuals in Jiangmen, Guangdong province between 2015 and 2017. Methods: HIV/AIDS cases from Chinese HIV/AIDS Comprehensive Response Information Manag...
Article
Since 2013, Muon Tomography technology has been developed at Tsinghua University. We have built up a prototype system named THUMTY (Tsinghua University cosmic ray Muon tomography facility) to do elementary research. Our research is focused on developing a muon NDT (Non Destructive Testing) system that will be used in homeland security operations su...
Article
To investigate the genetic diversity of Ralstonia solanacearum and effectively control tobacco bacterial wilt, 33 strains were isolated from Yihuang, Lichuan, Le??an, Guangchang, Zixi and Nanfeng in Fuzhou tobacco-planting areas and identified by PCR with primer 759/760. The genetic diversity of the 33 stains was analyzed by McRAPD and sequence of...
Article
Reporting standard system of clinical research of traditional Chinese medicine (TCM) is composed of ten reporting standards in the areas of the design and preparation of TCM clinical researches, researches of different types, randomized controlled trials of various interventions, systematic reviews of the trials and the translation of research evid...
Article
Full-text available
It makes use of the trade complementarity index, trade integration index and export concentration index to conduct an in-depth analysis of trade development process and the import and export structure of agricultural products between China with Russia from 2006 to 2017. The results show that degree of integration of China's agricultural trade with...
Article
The material performance parameters of NM450 wear resistant steel at different temperatures were calculated by the material scientific calculation software Jmatpro. By establishing the physical model and mathematical model of heat treatment for 60 mm thick NM450 steel plate, the variation law of temperature field, structural field, stress field and...
Article
Objective: To investigate the changes of thyroid hormones in hospitalized elderly patients and the relationship of levels of thyroid hormones with heart failure and with infection. Methods: A total of 252 hospitalized elderly patients without hypothalamus, pituitary and thyroid diseases in Department of Geratology from September 2016 to August 2017...
Article
[Objective] In order to study the mechanism of Tamarix hispida responsing to the salt stress, this study is committed to optimize the extraction method of total protein from the leaves of Tamarix hispida. The main purpose of this research is to explore the method of extracting total protein which is suitable for two-dimensional electrophoresis of T...
Article
With renewable energy generators integrated into power system, the fault current characteristics are greatly influenced. There exist adaptability issues when traditional protections are used in such system. Focusing on power-frequency based distance protection configured on the transmission line emanating from Inverter Interfaced Renewable Energy G...
Article
Clinical research reports are the main form of clinical evidence. Based on the requirements of clinical research reports and the characteristics of clinical research on traditional Chinese medicine, it is an important basic systematic project to construct a standardized system of clinical curative effects study report on Chinese medicine. This arti...
Article
Microstructure, mechanical property and corrosion resistance of low carbon steel (A), adding 0.18Cu (B) and 0.18Cu+0.18Cr pipe pile steel
Article
The abnormal activation of hedgehog (HH) signaling pathway plays an important role in the development and progression of glioblastoma (GBM). As a transcription factor at the end of the HH pathway, the final effector of glioma-associated oncogene homoglog-1 (GLI1) is an important target in the treatment of GBM. The study was designed to evaluate the...
Article
As the benchmark data for the design and evaluation of the thermal protection system, as well as the assessment data of the calculation method, the accuracy of thermal environment measurement data is of great importance. In this paper, the measurement discrepancy caused by the difference between the sensor surface and the surrounding heat-resistant...
Article
Towards the future CMS RPC upgrade, a real-size mosaic high-rate MRPC has been designed and developed by Tsinghua University. The prototype is a 5-gap counter composed of the low-resistive glass. Because the maximum size of this glass cannot exceed 330 × 280 mm², 6 regions of glass stacks are mosaicked together in order to achieve a large active ar...
Article
Since the new demands of power development, such as strengthening of distribution business, the implementation of alternative energy strategy, etc., make the upgrade and investment scale of distribution network continue to increase, it is important for guiding precise investment to research a set of reasonable and comprehensive evaluation model for...
Article
Objectives To explore potential important factors that impacts the quality of Chinese trials. Methods We randomly selected clinical studies registered in the Chinese Clinical Trial Registry during March 15th, 2016 to December 31st, 2016. The randomized controlled trials protocols were retrieved to assess the quality based on the SPIRIT guideline, t...
Article
Clinical trial transparency, include clinical trial registration, unbiased reporting results and sharing individual participant data (IPD), is one of the most important revolutionary concepts following clinical epidemiology and evidence-based medicine in the medical field. Sharing IPD is a medical ethics issue reflected a new sense of worth and con...
Article
In this study, a general method to obtain the 95% generation bound for photovoltaic (PV) systems worldwide was developed using a clear-sky model and then validated using ground surface observations, satellite-derived data, and typical meteorological year (TMY) files. The 95% generation bound for plane-of-array (POA) irradiation is used to provide t...
Article
Since the public clinical trial registration system was launched twelve years ago in China, as the primary register of the WHO International Clinical Trial Registry, the Chinese Clinical Trial Registry (ChiCTR) has largely promoted the development of clinical trial registration in China, particularly in recent three years. The quantity of registere...
Article
Data management system is a major factor affecting the quality of clinical trial. Development of data management system include a steering group and data safety and monitoring board, data collection, database, performance of the data safety and monitoring, as well as locking of database. This article provides key issues of the five parts so as to h...
Article
目的:分析乳腺癌分子分型与保乳治疗乳腺癌患者预后的关系,从分子分型角度探讨保乳手术的安全性问题。 方法:回顾性分析2005年8月至2010年8月天津医科大学肿瘤医院618例行保乳手术的乳腺癌患者,根据分子分型不同分为Luminal A型、Luminal B1型、Luminal B2型、人表皮生长因子受体2(human epidermal growth factor receptor-2, HER-2)过表达型、三阴性型,比较5型患者的临床病理特征及预后,分析局部复发、远处转移和总生存的影响因素。 结果: Luminal A型148例,Luminal B1型231例,Luminal B2型63例,HER-2过表达型40例,三阴性型136例。5种分子分型乳腺癌患者的年龄、肿瘤家族史、TNM分期、...
Article
Photovoltaic air-conditioner (PVAC) exhibits the advantages of high energy efficiency and convenient building integration, among solar cooling and heating technologies. The objective of this study is to propose a universal and straightforward method for performance evaluation of PVAC. Sixteen scenarios are simulated by TRNSYS to compare the perform...
Article
Objective To observe the impact of adaptive statistical iterative reconstruction-V (ASiR-V) on image quality and radiation dose in abdominal CT imaging, and to optimize combination of pre- and post-ASiR-V percentage. Methods Totally 160 patients underwent plain and contrast-enhanced abdominal CT were randomly divided into study group or control gro...
Article
Three different hybridization degrees of the three dimensional structure of graphene-carbon nanotube(G-CNT) were prepared by the different experimental schemes. The research on the mechanical property of the thermoplastic polyurethane(TPU) composites reinforced by this three-dimensional hybrid structure of the G-CNT, and the behavior of self-healin...
Article
With renewable energy generators (REGs) integrated into grid by the power converters, its fault current is featured with limited amplitude, non-power-frequency dominated and controlled phase angle, which leads to traditional relays based on power frequency facing low performance and even incorrect operations. In order to ensure a safe and reliable...
Article
Surface snow and atmospheric samples collected along a traverse from the coast to the ice sheet summit (Dome A) are used to investigate summertime atmospheric production of nitrate (NO3–) across East Antarctica. The strong relationship observed between δ¹⁵N and δ¹⁸O of nitrate in the surface snow suggests a large (lesser) extent of nitrate photolys...
Article
Multiple sclerosis (MS) is a disease characterized as inflammatory demyelinating of the central nervous system, which is the main cause of non-traumatic neurological disability in young and middle-age adults. The main manifestations of MS are memory and information processing speed, executive function and other cognitive impairments. MS associated...
Article
Full-text available
[Objective] Genome-wide association study (GWAS) was used to demonstrate the molecular mechanism and genetic architecture of chicken spleen weight, which will provide a basis for improving hens health condition in late laying period. [Method] The resource population was from reciprocal by Dongxiang Blueshell Chicken and White Leghon, the spleen wei...
Article
Tobacco leaves with strong, middle, fresh scent were tested in the experiments. The transmission spectra of the tobacco samples with different mass fraction (the mixture of tobacco and polyethylene) were obtained, and the corresponding absorption coefficient and refractive index spectra were calculated. Results show that tobacco leaves with differe...
Article
For incorrect segmentation caused by the lack of boundary information, a region-based multiscale segmentation method of panchromatic remote sensing image is proposed. Firstly, curvelet transform based multiscale analysis is used to obtain the multiscale decomposed image. Then its image domain is partitioned into a set of blocks by regular tessellat...
Article
Objective To assess the changes of white matter microstructure in neuromyelitis optica spectrum disorders (NMOSD) with DTI based on tract-based spatial statistics (TBSS) method. Methods Conventional MR and DTI were performed in 20 NMOSD patients (NMOSD group) and 20 healthy volunteers (control group). DTI data were analyzed with TBSS procedure, whi...
Article
A shashlik-type electromagnetic calorimeter will be produced in Hall A of Jefferson Laboratory for the Solenoidal Large Intensity Device (SoLID). Wavelength-shifting (WLS) fibers and clear fibers will be used as the light guide part of the calorimeter. The blue light from scintillators is converted into green light by WLS fibers and is carried out...
Article
Objective: To investigate the relationship between the content of human telomerase reverse transcriptase (hTERT) and its clinical features in serum free DNA in patients with different degree of spinal cord injury. Methods: From December 2013 to December 2016, inpatients of the Central Hospital of Bazhong, Sichuan Province were enrolledand divided i...
Article
Nitrogen (N) application and irrigation to winter wheat may decrease leaf temperature and enhance photosynthesis: as a result, more photosynthates will be allocated to the grains, resulting in higher grain yields. To investigate this hypothesis, a 2-year field study was conducted with three levels of N fertilizer application (no fertilizer, N0; 240...
Article
目的: 探讨肝脏原发黏膜相关淋巴组织结外边缘区(MALT)淋巴瘤和肝脏假性淋巴瘤的临床病理特征、鉴别诊断。 方法: 收集2012年1月至2017年3月就诊于南京医科大学第一附属医院的3例肝脏原发MALT淋巴瘤和2例肝脏假性淋巴瘤患者资料,行HE和免疫组织化学EnVision法染色观察组织学形态,采用原位杂交法检测EB病毒编码小RNA,采用荧光原位杂交(FISH)技术检测MALT1基因,采用免疫球蛋白(Ig)基因重排检测技术分析克隆性基因重排情况,并复习相关文献。 结果: 3例MALT淋巴瘤,肿瘤结节状浸润汇管区,浸润及包绕周围肝组织并融合成结节或片状,多量小胆管陷入、散布其间伴淋巴上皮病变。瘤细胞围绕增生的淋巴滤泡,主要为中心细胞样和单核样B细胞,其中1例可见簇状上皮样组织细胞。瘤细胞CD2...
Article
Since a new round of electricity market reform, power retailers grow up rapidly. How to participate in electricity market to bid for maximum profit becomes one of their core issues. Combined with background of power source interconnection, this paper studied strategy of comprehensive power retailers participating in market bidding under multiple us...
Article
Although metal accumulation has been investigated in coastal Antarctic soil, the information about to what extent station activities influence soil quality remains limited, especially in East Antarctica. Here, we carried out an investigation on element accumulation (Pb, Zn, Cu, Ni, Mn, Cr, Ti, Zr, Fe, Ca, K, Al, Mg and Na) in topsoils collected fro...
Article
Indoor pot experiments were performed to investigate the effects of Cyperus glomeratus L. and Vicia faba L. intercropping on the chemical forms of Cd, Pb, and Zn found in the plants and soil. Intercropping reduced the biomass of the shoots and roots, soluble sugar content, and chlorophyll content of C. glomeratus by 54.55%, 41.67%, 36.39%, and 33.3...
Article
Rice blast is an important factor limiting rice production. The enhancement of UV-B radiation on the earth's surface affects the interaction system between rice and Magnaporthe oryzae(M). In order to elucidate the effect of compound stress on rice growth, the traditional rice variety "Baijiaolaojing" was implanted in the rice field of the ultraviol...
Article
The Chenjiaba deposit is a new Cu - Pb - Zn polymetallic deposit discovered in Mianx-ian-Lueyang-Yang Pingguan triangle area, Shaanxi Province. Based on the geochemical comparison between trace elements and rare earth elements in ore and geological bodies, the ore-forming fluid characteristics and metallogenic mechanism of this deposit have been st...
Article
In recent years, CRO has developed rapidly in China, and has played an important role in improving the level of Chinese clinical trials and drug development. However, the development of CRO industry also has problems. This paper discusses the beneficial factors of the main problems and the future direction of CRO, in attempt to attract the attentio...