Y. I. Sternin’s research while affiliated with North-Western State Medical University named after I.I. Mechnikov and other places

Purpose. The wide range of the factors promoting emergence of GLD and also specificity of racial features of this disease testify to importance of studying of the genetic reasons of hereditary predisposition to development of GLD. Design/methodology/approach. PCR-RFLP analysis of the studied polymorphism of genes associated with the formation method of lipodystrophy, and estimated of genetic testing results. Findings. There is a correlation between GLD and allelic variants of genes (MMP3, ACE, NOS3), whose products are involved in collagen metabolism, and the cardiovascular system by regulating blood microcirculation the violation of which plays the essential role in the development of GLD. Practical implications. These results suggest the use of treatment aimed at solving the problems of the microcirculation is important for the treatment of patients with GLD.

An experimental group of 45 nondescript white mice was selected for a study of the influence of systemic enzyme therapy on performance and ability to withstand intensive physical loads, as well as on production of main cytokines. The findings were compared to a control group of 45 mice who received placebo. The physical performance was assessed after 1, 2, and 3 weeks according to the length of test swimming in the aquarium with the attached load of 5% of the body mass. Findings indicate that systemic enzyme therapy led to increased performance and endurance with increased physical load in the experimental group after three weeks of therapy. The mice in the experimental group showed decreased levels of anti-inflammatory TNFα and IL - 1β. Other observed changes were within the error range. (Med. Immunol., vol. 10, N 6, pp 577-582).

One of the perspective treatment methods in pediatric practice is system enzyme therapy. The action mechanism of system enzyme therapy (Wobenzyme) was represented, such as inflations on the inflammatory process, immune system, vascular thrombocyte homeostasis. Separately examine the problems of Wobenzyme and antibiotic interaction, and also clinical researches of several diseases in pediatrics.