Xuhua Guan's research while affiliated with Hubei Provincial Center for Disease Control and Prevention and other places

Publications (51)

Article
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Background The enterovirus 71 (EV71) vaccine produced by Wuhan Institute of Biological Products Co., Ltd. (WIBP) (B-EV71) has been given to children aged 6-35 months, and it has shown good safety, immunogenicity and efficacy. However, the administration of EV71 vaccine in children aged 36-71 months, which is another target population, needs further...
Article
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Background To mitigate a national shortage of WIBP-CorV COVID-19 vaccine, China’s regulator approved administering BBIBP-CorV after WIBP-CorV for completion of a primary series. In a pragmatic observational study, we compared immunogenicity and safety of a primary series of WIBP-CorV followed by BBIBP-CorV with a primary series of two doses of BBIB...
Article
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Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997. Methods A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR ampl...
Article
Objective: The study aimed to timely grasp the epidemiologic status of rabies in Central China from 2013 to 2018 and provide scientific evidence for the implementation of follow-up prevention and control measures. Methods: We initiated a retrospective observational and descriptive study of bite-related injuries data and rabies disease data in Hu...
Article
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Background: Knowledge of COVID-19 epidemiology remains incomplete and crucial questions persist. We aimed to examine risk factors for COVID-19 death. Methods: A total of 80 543 COVID-19 cases reported in China, nationwide, through April 8, 2020 were included. Risk factors for death were investigated by Cox proportional hazards regression and str...
Article
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Background China implemented containment measures to stop SARS-CoV-2 transmission in response to the COVID-19 epidemic. After the first epidemic wave, we conducted population-based serological surveys to determine extent of infection, risk factors for infection, and neutralization antibody levels to assess the real infections in the random sampled...
Preprint
Full-text available
Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has been changing since a large scale of outbreaks occurred in 1997. A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and...
Article
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Coxsackievirus A6 (CV-A6) and Coxsackievirus A10 (CV-A10) have been emerging as the prevailing serotypes and overtaking Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16) in most areas as main pathogens of hand, foot and mouth disease (HFMD) in China since 2013. To investigate whole etiological spectrum following EV-A71 vaccination of approxi...
Preprint
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Discharged COVID-19 patients have been found to be retested positive for SARS-CoV-2 (re-positive), which has widely raised concern among the public. We investigated the prevalence and transmission risk of re-positive cases in discharged COVID-19 patients and their SARS-CoV-2-specific antibody levels in Wuhan, China. Of 1065 discharged COVID-19 pati...
Article
What is already known on this topic?: Human brucellosis, a neglected zoonotic disease, causes more than 500,000 new cases each year globally. The disease is of major public health concern in China, and northern provinces are traditionally endemic areas. What is added by this report?: This is the first published outbreak of occupational brucellos...
Article
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Background: Shigellosis is one of the main diarrhea diseases in developing countries. However, the transmissibility of shigellosis remains unclear. Methods: We used the dataset of shigellosis cases reported between January 2005 and December 2017, from Hubei Province, China. A mathematical model was developed based on the natural history and the...
Article
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Background: The initial cases of novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, Hubei Province, China, in December 2019 and January 2020. We analyzed data on the first 425 confirmed cases in Wuhan to determine the epidemiologic characteristics of NCIP. Methods: We collected information on demographic characteristics,...
Article
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Background: In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. Methods: The case definition was that a child with onychomadesis or transverse ridging (Beau's line) in fingernails and toenails without previous traumatic or syst...
Article
Background: Evaluation of a licensed inactivated EV71 vaccine is needed in a phase IV study with a large population to identify its effectiveness and safety for further application. Methods: An open-label and controlled trial involving a large population of 155,995 children aged 6-71 months is performed; 40,724 were enrolled in the vaccine group...
Article
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Background/aims: Nucleotide diversity may affect the immune regulation of tuberculosis (TB) patients, leading to the individual susceptibility to TB. In recent years, there are a lot of researches on the association of host genetic factors and TB susceptibility which has attracted increasing attention, and the in-depth study of its mechanism is gr...
Article
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We aimed to investigate the epidemic situation of tuberculosis (TB) in prisons in the central region of China. Tuberculosis screening was carried out in two prisons in middle China. A sum of 3,459 prisoners accepted chest X-ray examination; 40 of them were diagnosed as active TB patients. The active TB prevalence (1,156/105) was significantly highe...
Article
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Background: In 2017, an outbreak of onychomadesis occurred in kindergarten H, Hubei province, China. We investigated the field to learn about the magnitude and reason of the outbreak. Methods: The case definition was that a child with onychomadesis or transverse ridging (Beau's line) in fingernails and toenails without previous traumatic or systemi...
Article
PPARγ and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). We recruited 100 IS patients diagnosed by CTs or/and...
Article
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Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified...
Article
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Background The prevalence of tuberculosis (TB) in low and middle-income countries is a significant public health and social concern. TB is a common infectious disease caused by the Mycobacterium tuberculosis infection, which has a widespread infection rate. Health care-seeking delay maybe one of the most important neglected risk factors for the spr...
Article
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Background Streptococcus pneumoniae (Sp) is a leading cause of bacterial pneumonia, meningitis, and sepsis and a major source of morbidity and mortality worldwide. Invasive pneumococcal disease (IPD) is defined as isolation of Sp from a normally sterile site, including blood or cerebrospinal fluid. The aim of this study is to describe outcomes as w...
Data
Characteristics of hospitalized SARI and meningitis patients in Jingzhou, China, from April 2010—September, 2012. (DOCX)
Article
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Background: Mumps vaccine immunizations have reduced the incidence of this disease. With the variation of mumps circulating strain, novel vaccine strains are always important. Method: A two-center parallel, randomized, double-blind noninferiority trial was performed to compare an F-genotype attenuated mumps vaccine (SP strain) to the A-genotype...
Article
Background Pleiotropic cytokine interleukin-10 (IL-10) has been suggested as modifying risk for atherosclerosis. Promoter region genetic polymorphism of IL-10 gene is known to be associated with the level of IL-10 production. Through these effects, they might be involved with the ischemic stroke (IS). Our aim was to assess the nature of the functio...
Article
Norovirus (NoV) is a major pathogenic agent of human acute viral gastroenteritis that occurs worldwide. In March 2017, a series of acute NoV-associated gastroenteritis outbreaks occurred in Hubei Province in central China. Here, we sought to better understand the main genotypes and potential evolutionary advantages of circulating NoV strains underl...
Article
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Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily series of HFMD counts and meteorolog...
Article
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The complete mitogenome sequence of the flea, Ceratophyllus wui (Siphonaptera: Ceratophyllidae), was sequenced. The 18,081 bp long genome has the standard metazoan complement of 37 genes. These genes contain 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and one control region. The nucleotide composition of the C. wui mito...
Article
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Background: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. Methods: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were...
Article
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Background: Influenza is an important cause of respiratory illness in children, but data are limited on hospitalized children with laboratory-confirmed influenza in China. Methods: We conducted active surveillance for severe acute respiratory infection (SARI) (fever and at least one sign or symptom of acute respiratory illness) among hospitalize...
Article
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Background: After the 2009 influenza A (H1N1) pandemic, we conducted hospital-based severe acute respiratory infection (SARI) surveillance in one central Chinese city to assess disease burden attributable to influenza among adults and adolescents. Methods: We defined an adult SARI case as a hospitalized patient aged ≥ 15 years with temperature ≥...
Article
Severe fever with thrombocytopenia syndrome (SFTS), an emerging high-fatality infectious disease, is caused by a novel bunyavirus. However, a clear natural transmission model has not yet been established. We conducted a cross-sectional study with in-depth investigation of villages to systematically understand the transmission and risk factors among...
Article
Background: PPARx03B3; and PPARα belong to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). Methods: One thousand two hundre...
Article
To estimate the hospitalization rate of severe acute respiratory infection (SARI) cases attributable to influenza in Jingzhou city, Hubei province from 2010 to 2012. SARI surveillance was conducted at four hospitals in Jingzhou city, Hubei province from 2010 to 2012. Inpatients meeting the SARI case definition and with informed consent were enrolle...
Article
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Background Respiratory Syncytial Virus (RSV) is an important human respiratory pathogen, particularly of infants and older adults, and despite several decades of research and development, no licensed vaccine is available. Studies have confirmed that enhancement of RSV disease does not occur after inoculation with RSV live-attenuated vaccine candida...
Article
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Published data on influenza in severe acute respiratory infection (SARI) patients are limited. We conducted SARI surveillance in central China and estimated hospitalization rates of SARI attributable to influenza by viral type/subtype. Surveillance was conducted at four hospitals in Jingzhou, China from 2010 to 2012. We enrolled hospitalized patien...
Article
Endothelial nitric oxide synthase (eNOS) play an important role in mediating endothelium-dependent vasodilatation and antithrombotic action and thus involved in the development of ischemic stroke (IS). Controversial results regarding the association of eNOS gene variable number of tandem repeats (VNTR) polymorphism with IS have been reported by con...
Article
Recent genome-wide association studies (GWAS) have identified two key SNPs (rs11833579 and rs12425791) on chromosome 12p13 that were significantly associated with stroke in Caucasians. However, the validity of the association has remained controversial. We performed genetic association analyses in a very unique population which has 60% European anc...
Article
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Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction and death; however, underlying pathogenic mechanisms remain unclear. Methods: Serum samples from 15 fatal and 44 nonfatal SFTS cases were subjected...
Data
Pneumonia incidence in China, by region. (0.10 MB DOC)
Article
Full-text available
Pneumonia is a leading infectious disease killer worldwide, yet the burden in China is not well understood as much of the data is published in the non-English literature. We systematically reviewed the Chinese- and English-language literature for studies with primary data on pneumonia incidence and mortality in mainland China. Between 1985 and 2008...
Data
Pneumonia case definitions used in the studies reviewed. (0.06 MB DOC)
Data
Pneumonia mortality in China, by region. (0.18 MB DOC)
Article
Full-text available
Timothy M. Uyeki,¶ ¶ and Weizhong Yang,* for the Avian Influenza H5N1 Study Group 2 We investigated potential sources of infection for 6 confi rmed infl uenza A (H5N1) patients who resided in urban areas of People’s Republic of China. None had known exposure to sick poultry or poultry that died from illness, but all had visited wet poultry markets...

Citations

... Such ambiguity hinders the use of these estimates for further analyses [2]. In mainland China, HFMD outbreaks primarily occur in relatively closed units such as kindergartens (usually for 3-to 6-year-olds) and elementary schools (usually for 6-to 12-year-olds) [9,10]. Thus, one of the foci of HFMD prevention and control is to intervene in a timely manner at these key locations. ...
... Similarly, it was believed that the CVA5 has become a significant cause of a range of disorders in recent years, including herpangina, onychomadesis, stomatitis and even acute encephalopathy [32]. The recombination between the A2 and A5 was noteworthy, as similar recombinants in other regions were reported for HFMD epidemics [33]. ...
... Case-fatality ratios were less than 1% for those younger than 50 years, 3·1% for those aged 50-59 years, 8·2% for those aged 60-69 years, 18·5% for those aged 70-79 years, and 32·1% for those 80 years and older. 47 Older age was also associated with a reluctance to accept COVID-19 vaccination. 48 ...
... Compared to previous local SARS-CoV-2 outbreaks that emerged in China after the original COVID-19 wave, the rapid spread of the Omicron outbreak in Shanghai was likely driven by the high transmissibility and/or immune-escape properties of Omicron BA.2. 26 The immunological landscape of Shanghai at the onset of this outbreak was fragile, with essentially no prior natural immunity (less than 0.01% of the population was infected prior to the outbreak 27 ). In addition, although the coverage of the primary vaccination series exceeded 90% of the total population, the vaccination coverage for individuals aged ≥ 60 years was relatively low (62% for the primary series and 38% for the booster dose 12 ). ...
... In our previous study, the same method was used to prepare the Vero cell-based inactivated CV-A2, CV-A5 and CV-A6 vaccine [24,26,27]. This strategy can be widely applied in the development of other HFMD vaccines where the viruses cannot be easily isolated and efficiently propagated in high titers in Vero and MRC5 cell lines [7]. ...
... An outbreak of human brucellosis in Jiangsu Province was caused by the plentiful influx of unchecked sheep from Northern China and the lack of an effective prevention programme [20]. Zhang Z et al. reported the first outbreak of occupational brucellosis involving multiple clusters in Hubei Province, China in 2019, which was due to the influx of infected goats and mutton [21]. Importing an infected goat was the core link that may lead to the local brucellosis outbreak in Fujian Province, China [22]. ...
... The characteristic equation (ρ(t), electronic supplementary material, table S1-S6 and highlighted as green in figure 1) captures the transmissibility of the pathogen during the infectious period [23], which for shigellosis (as a cause of diarrhoea) was 7 days, and, on each day, the probability of transmission varies depending on incubation time, symptom progression, and recovery during that time frame. For the disease transmission model, diarrhoea (e.g. ...
... The first known case of the virus in Nigeria was documented on the 27th of February 2020 and since then the number of confirmed cases has been on the increase [1,2]. The epidemiological pattern of the COVID-19 virus suggested an incubation period of five to fourteen days [3,4], with a recent report suggesting a twenty-four days incubation period [5]. ...
... It had been reported that CVA6 was associated with increasingly sporadic HFMD outbreaks in some countries [22,23]. Furthermore, cases associated with this type featured a clinical symptom of onychomadesis sometimes [24,25]. ...
... Phase III and IV clinical trials have verified that the C-EV71 vaccine could elicit EV71-specific immune responses and protect against EV71-associated HFMD in children aged 6-71 months. 21,22 Methods ...