Xu-ming Bian's research while affiliated with Peking Union Medical College Hospital and other places

Publications (34)

Article
Full-text available
The ratio of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) is elevated and proved to be useful in preeclampsia (PE) diagnosis. Its value in differential diagnosis with other pregnancy complications and prediction of pregnancy duration has yet to be clarified in Chinese population. We retrospectively analyzed 118 single...
Article
The incidence of autosomal trisomy in livebirths is strongly dependent on maternal age. Special consideration is given to the provision of prenatal screening and cytogenetic testing to women of advanced maternal age (AMA). The aim of this study was to evaluate the effectiveness of second trimester prenatal screening and amniocentesis for Down syndr...
Article
Objective: To investigate the clinical features and pregnant outcomes of the pregnant women with congenital adrenal hyperplasia (CAH) 21-hydroxylase deficiency (21-OHD). Methods: The clinical features, therapies, pregnant outcomes of the pregnant women with 21-OHD were retrospectively reviewed in Peking Union Medical College Hospital, from Janua...
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To investigate the the relationship of a high risk serum screen for Down syndrome in second trimester and adverse pregnancy outcomes, and to evaluate the predictive value for adverse pregnancy outcomes. The tri-marker second trimester maternal serum screening for Down syndrome (alpha-fetoprotein, free beta-hCG and unconjugated estriol) was performe...
Article
To discuss the interaction of pregnancy and myasthenia gravis (MG) and the management of pregnancy with MG. Seven cases of pregnancy with MG in Peking Union Medical College Hospital were analyzed retrospectively, with respect to the therapy of MG, pregnancy complications and outcomes. Totally 38,683 pregnant women were admitted to Peking Union Medi...
Article
To discuss the interaction between pregnancy and ankylosing spondylitis, and the management of pregnancy with ankylosing spondylitis. Twelve cases of pregnancy with ankylosing spondylitis in Peking Union Medical College Hospital from September 2004 to July 2011 were analyzed retrospectively, focusing on the arteritis condition, pregnancy complicati...
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To summarize the workflow, strategy and experience of prenatal genetic test for deafness based on the 6-year clinical practice. There were 213 families who received prenatal test from 2005 to 2011. Among the 213 families, 205 families had had one deaf child, including 204 couples with normal hearing and one couple of the deaf husband and normal wif...
Article
Anemia during pregnancy and the postpartum period is commonly caused by iron deficiency and is a significant worldwide issue with severe consequences for both mother and developing fetus. From a worldwide perspective, iron-deficiency anemia (IDA) during pregnancy is highest in the Asia-Pacific region; however, there has been little guidance in this...
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Prenatal screening and diagnosis are major methods for control of birth defects, which is a very important problem in China. Here, we review current situation and development of prenatal screening and diagnosis in mainland China, including prenatal screening and prenatal diagnosis of fetal chromosome abnormalities, non-invasive prenatal diagnostic...
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To establish the multiple quantitative fluorescent polymerase chain reaction (QF-PCR) assay and evaluate its clinical application in prenatal diagnosis. Totally 170 samples were collected between May 2008 and July 2009 in prenatal center of Peking Union Medical College Hospital; 123 of them were amniotic fluid, 9 were chorionic villous samples, 20...
Article
To evaluate the effect of elective repeat cesarean section on the maternal and neonatal outcomes. A retrospective clinic- and hospital-based survey was designed for comparing the maternal and neonatal outcomes of elective repeat cesarean section [RCS group (one previous cesarean section) and MRCS group (two or more previous cesarean sections)] and...
Article
To explore the relationship between pregnant outcomes and the maternal serum level of a disintegrin and metalloprotease 12 (ADAM 12) in the first trimester. From July 2007 to January 2008, the serum levels of ADAM 12 of 511 women in their first trimester (6 - 13 gestational weeks), who attended the clinics at Peking Union Medical College Hospital,...
Article
Small for gestational age (SGA) infants are associated with a high rate of oligohydramnios, stillbirth and cesarean delivery. Among SGA patients there is a higher risk of neonatal complications, such as polycythemia, hyperbilirubinemia, and hypothermia. Additionally, the SGA infant is prone to suffer from major neurologic sequelae, as well as cardi...
Article
To evaluate the performance characteristics of the second trimester double-marker test for the detection of fetal Down's syndrome in mainland China. This prospective national multi-centered study used alpha-fetoprotein (AFP) and free beta-subunit of human chorionic gonadotrophin (free beta-hCG) as the serum markers. From May 2004 to September 2006,...
Article
To evaluate the performance characteristics of the second trimester double test for the detection of fetal Down's syndrome (DS) in women of advanced maternal age (AMA). We undertook a prospective nation-wide multi-centered study and chose alpha-fetoprotein (AFP) and free beta-subunit of human chorionic gonadotrophin (free beta-hCG) as the serum mar...
Article
To investigate the effect of pregnancy and spontaneous delivery on the morphologic characteristics of the levator ani muscle and innervation of the vaginal mucosa. Eight nullipara without pelvic floor dysfunction (PFD) and 64 normal primipara undergoing spontaneous delivery were enrolled in this study during July to December 2006 in Peking Union Me...
Article
To explore the clinical characters, diagnosis and treatment methods of placenta accreta. A retrospective analysis was made of 47 cases of placenta accreta admitted during May 1997 to May 2007 into Peking Union Medical College Hospital. They included 17 cases in the second trimester and 30 cases in the third. Among all the patients, the incidence of...
Article
To estimate the maternal-neonatal morbidity associated with induction deliveries compared with spontaneous deliveries in 41 gestational weeks uncomplicated primiparae. Three hundred and seventy-four uncomplicated primiparous deliveries at 41 gestational weeks at Peking Union Medical College Hospital from Sept 2002 to Apr 2007 were reviewed, includi...
Article
Traumatic damage to fascial and muscular support structures during childbirth may be a major factor of the development of stress urinary incontinence (SUI) and pelvic organ prolapse (POP). The aim of this study was to prospectively investigate the role of different childbirth strategies on POP and SUI. A total of 120 selected pregnant women were re...
Article
To investigate the effect of different delivery modes and related obstetric factors on the short-term function of the pelvic floor. One hundred and twenty healthy primiparae women were interviewed at 6-8 weeks postpartum, with 72 women in the vaginal delivery group and 48 women in the elective cesarean section group. Questionnaire on stress urinary...
Article
To compare maternal and neonatal outcomes after induction, elective cesarean section and spontaneous onset of labor in uncomplicated term nulliparous women. A total of 3751 uncomplicated term nullipara who delivered in Peking Union Medical College Hospital from Sept 2002 to April 2007 were retrospectively analyzed. They were divided into three grou...
Article
To study the relationship between early spontaneous abortion and living environment, and explore the risk factors of spontaneous abortion. We conducted analysis based on the interview of 200 spontaneous abortion cases and the matched control (age +/- 2 years) by using multifactor Logistic regression analysis. The proportions of watching TV > or =10...
Article
To provide prenatal diagnosis for deaf families, which the first child was confirmed to be hereditary deafness caused by gap junction beta-2 (GJB2) or SLC26A4 (PDS) mutation, to avoid another deaf birth in these families. Eight deaf families joined in this study. Each family had one child with severe to profound hearing loss while parents had norma...
Article
To understand the correlation of lower serum folate, and red blood cell (RBC) folate level with birth defects including unexplained recurrent pregnancy loss, and to evaluate the role of RBC folate level as a suitable marker for folate supplement. Two hundred and ninety-nine non-pregnant women at child-bearing age with a birth defect history were se...
Article
To study the accuracy of the application of the intrapartum fetal oxygen saturation (FSO2) monitoring in predicting fetal acidosis and diagnosing intrauterine fetal distress. Continuous FSO2 monitoring as well as internal and external fetal heart rate monitoring were applied respectively in 60 women in labor during active phase of the first stage a...
Article
To investigate the optimal method of screening for Down's syndrome (DS) with maternal serum mankers. Screening by maternal serum markers for Down's syndrome was offered to all 2886 pregnant women in Peking Union Medical Hospital during 1996.11-2001.3. Alpha-fetoprotein (AFP), human chorionic gonadotrophin (free beta-HCG) were used as markers during...
Article
To observe Chinese women's cervical physiological changes by transvaginal ultrasound. 637 normal female volunteers were studied. Cervical length, width and canal width were measured by transvaginal ultrasound. Cervical length multiplied by width was the biggest vertical section area of cervix(cervical area). The cervical length, width, area and can...
Article
To set up a new technique of continuous medical image digital restoration for electronic record management. According to Freeman's chain-code principle, 92 fetal cardiotocography were scanned, thinned, trailed, and chain-coded by computer system. 92 paper-recorded cardiotocography, were transformed to digital data and saved by computer, 23 paramete...
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To review the management of postpartum hemorrhage (PPH). Fifteen cases of severe PPH were retrospectively analyzed for clinical parameters and management. Nine patients had a hysterectomy while selective arterial embolization was carried out in 7 cases. One patient had focus clearance. The main causes of postpartum hemorrhage requiring operative ma...

Citations

... Prognostic models based solely on the classical clinical risk factors (high blood pressure and proteinuria) have been reported to have poorer predictive ability compared to the models developed using sFlt-1 and PIGF biomarkers [10,11]. However, most of the prognostic models built using sFlt-1, PIGF, or their ratio are based on dichotomising the continuous measurements of these markers using threshold values [4,5,[12][13][14][15]. Moreover, only few studies have modelled or compared sFlt-1, PIGF, or their ratio on a continuous scale [16][17][18]. ...
... During pregnancy, there is remodelling in vessel walls with endothelial cell proliferation. These changes may be associated with an increase in the size of the cavernoma and a higher risk of bleeding[3][4][5]. ...
... Prenatal ultrasonography for soft markers of chromosomal aneuploidy, accompanied by maternal serum biochemical screening tests, should be evaluated during the decision-making process when considering genetic amniocentesis in women of AMA. Patients should be educated by recommending women of AMA to be informed of both screening and amniocentesis options [25,26]. We also found that the AUCs were 0.783, 0.767 and 0.858, respectively, for the PPVs of free β-hCG MoM, AFP MoM, and the risk value for Trisomy 21 in women of AMA. ...
... Several groups, including the International Society for Prenatal Diagnosis (ISPD), the American College of Obstetricians and Gynecologists (ACOG) and the American College of Medical Genetics (ACMG), have published committee opinions or guidelines for the clinical application of this new technology in screening for the more common autosomal trisomies, i.e. trisomies 13, 18 and 21 12,13 . In 2012, the Committee of Prenatal Diagnosis in China also published positive opinions on the use of this technology 14 . ...
... Any chemical stimulus or injury at this stage may easily affect the ongoing developmental process and carry a life-long impact. An imbalance in androgen concentration at this early embryonic stage was associated with polycystic ovarian formation 18 . Widdowson et al. 19 concluded that excess androgen disturbed reproductive functioning by its action on the hypothalamic-pituitary-gonadal axis. ...
... Recent reports from Asia quoted an incidence of 5-7 per 20,000. 3,4 However, the presence of these two entities in a parturient has been rarely reported. Herein this report we have described a 35 years G2P1L1 a known case myasthenia gravis presenting in emergency with uncontrolled hypertension and had laboratory features of HELLP syndrome. ...
... In PsA, in which conclusions have been based on the RA observations, later studies found contradictory results [11,12]. In axSpA, the results also vary according to the studies: some report no particular change during pregnancy [9,13,14], whereas others report a worsening in the later stages of pregnancy. ...
... 4 There have been reports of prenatal diagnosis of mutations in SLC26A4 in the Chinese literature. 5 We report the postnatal audiological course in a patient with prenatal diagnosis of SLC26A4 mutations. In this case, the known genetic status of the newborn prompted frequent audiological testing. ...
... Low newborn CCHD prevalence appears to be associated with the widespread implementation of the prenatal diagnosis service, which was promoted by the National Regulation on the Administration of Prenatal Diagnosis Techniques since 2003 in mainland China. 13 According to the National Regulation, pregnant women are recommended to have systematic ultrasound examinations to screen for birth defects in the second trimester and a pregnancy affected by severe birth defects is legally allowed to be terminated through a standardized process. 13 As a consequence of the widespread use of prenatal sonography, a proportion of fetuses with CCHD could be diagnosed prenatally and terminated before 28 weeks of gestation, which might, in part, result in the decrease in the newborn CCHD prevalence. ...
... Increased maternal age, obesity, iron deficiency, thyroid dysfunction, abnormal iodine nutritional status, smoking and drinking have been reported as potential risk factors for miscarriage in previous studies (6,31,(35)(36)(37). In this study, the number of subjects with a smoking and alcohol use history were both too small to be included in the LRA. ...