Xu-Kai Wang's research while affiliated with Center For Oral & Maxillofacial Surgery and other places

Publications (42)

Article
Intracapsular condylar fracture in children and adolescents may damage the condylar cartilage and hinder the growth of mandibular branch, but the treatment of the pediatric/children’s intracapsular fracture is still an academic controversy. In this study, we build the intracapsular condylar fracture models in miniature pigs and make the three-dimen...
Article
Non-selective β-blocker propranolol has been proved by FDA as the first-line agent for infantile hemangioma (IH) with dramatic response. To reduce the side effects caused by systemic administration of propranolol, timolol maleate treatment has been increasingly used as an alternative to systemic β-blockers and watchful waiting for many IH patients...
Article
Full-text available
The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propn olol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1.5 mg/kg/day to 22 infants with proliferating hemangiomas in the Department of Oral and Maxillofacia...
Article
The objective of the study was to discuss the construction methods, characterization and biocompatibility of silk fibroin-gelatin (SF-G) three-dimensional scaffolds which meet the requirements of bone tissue engineering scaffolds. Silk fibroin (SF) and gelatin (G) were lyophilized at different temperature such as -20 °C, -40 °C, -60 °C, -80 °C then...
Article
Full-text available
The role of transforming growth factor-β1 (TGF-β1) in normal human fracture healing has been previously demonstrated. The objective of the present study was to examine the biocompatibility of TGF-β1-silk fibroin-chitosan (TGF-β1-SF-CS) three-dimensional (3D) scaffolds in order to construct an ideal scaffold for bone tissue engineering. We added TGF...
Article
Full-text available
Infantile hemangioma (IH) is one of the most common benign vascular tumors in children. A variety of treatment methods have been documented for the management of IH over the past years, including pharmacotherapy via oral administration or injection of corticosteroids, vincristine, alpha interferon and bleomycin; laser therapy, radionuclide therapy,...
Article
Purpose: Periorbital infantile hemangiomas (IHs) require early intervention because they have the potential risk of causing visual disturbances. In recent years, propranolol has shown promise in the effective management of periocular and periorbital IHs. The objective of our study was to assess the clinical outcomes, efficacy, and safety of propra...
Article
Purpose Infantile hemangiomas (IHs) are the most common benign tumors affecting infants, and most IHs are self-limiting. However, there are cases that require specific treatment. Propranolol is now widely used to treat severe IHs. Several studies have shown the efficacy and limited side effects associated with propranolol as the first-line treatmen...
Article
The objective of the study was to discuss the biocompatibility of the vascular endothelial growth factor-silk fibroin-chitosan (VEGF-SF-CS) scaffolds. To offer an ideal scaffold for bone tissue engineering, the author added vascular endothelial growth factor (VEGF) into silk fibroin-chitosan (SF-CS) scaffold directly to reconstruct a three-dimensio...
Article
Purpose: The combination treatment for mix infantile hemangiomas (IHs) using oral propranolol with topical timolol maleate was not well documented in the literature. The aim of this study was to evaluate the therapeutic effects and safety of oral propranolol along with topical timolol maleate or oral propranolol alone for treating mixed IHs in the...
Article
Full-text available
The aim of the present study was to examine the biocompatibility of transforming growth factor-β1-silk fibroin-chitosan (TGF-β1-SF-CS) scaffolds. In order to provide an ideal scaffold for use in bone tissue engineering, TGF-β1 was introduced into the SF‑CS scaffold in order to reconstruct a three dimensional scaffold, following which hFOB1.19 osteo...
Article
Our aim was to compare in a prospective study the clinical effects and safety of propranolol given orally, timolol maleate applied locally, and the combination of the two, in the management of superficial infantile haemangiomas. Thirty-nine patients with superficial infantile haemangiomas were randomised into three equal groups of 13 each: the firs...
Article
The objective of this study was to discuss the construction method, characterization, and biocompatibility of three-dimensional silk fibroin-chitosan (SF-CS) scaffolds which met the requirements of bone tissue engineering scaffolds. Silk fibroin (SF) and chitosan (CS) were mixed at different ratios -3 to 7, 5 to 5, and 7 to 3- to fabricate the comp...
Article
The objective of the study was to discuss the biocompatibility of VEGF-silk fibroin-chitosan (VEGFSF- CS) three-dimensional scaffolds in order to offer an ideal scaffold for bone tissue engineering. Bone marrow derived mesenchymal stem cells (BMSCs) were seeded on the VEGF-SF-CS three-dimensional scaffolds and silk fibroin-chitosan (SF-CS) three-di...
Article
The purpose of the article was to assess the clinical results of mattress cerclage combined with electrochemical therapy and pingyangmycin injection after embolization in treating arteriovenous malformations (AVMs). During the period from January 2008 to December 2012, a total of 26 patients with AVMs were treated through mattress cerclage combined...
Article
The aim of our study was to assess the efficacy and safety of oral propranolol for the treatment of parotid infantile hemangiomas. Between October 2009 and January 2013, propranolol was given orally to 30 infants with proliferating hemangiomas at a dose of 1.0 to 1.5 mg/kg per day in our department. The patients included 12 male infants and 18 fema...
Article
The aim of the present study was to evaluate the therapeutic outcome of using electrochemical therapy (ECT) combined with a sclerosing agent, pingyangmycin (bleomycin A5 hydrochloride; PYM), for large (>3 cm in diameter) venous malformations (VMs) in the oral and maxillofacial regions. Thirty-five patients (15 male and 20 female; age range, 10 to 6...
Article
The objective of this study was to assess the clinical effects and safety of topical timolol maleate for the management of superficial infantile hemangiomas (IHs). From October 2012 to March 2014, 35 infants (24 girls and 11 boys; 2 to 10 months old; median age, 4.7 months) with superficial hemangiomas were treated with the local application of tim...
Article
Purpose The aim of this study was to investigate the therapeutic results and effects of propranolol on cardiovascular parameters in infants with systemic propranolol for complicated infantile hemangiomas (IHs), as well as to evaluate the adverse effects of propranolol throughout the course of treatment. Materials and Methods Twenty-five consecutiv...
Article
The objective of this study was to investigate the therapeutic effects and safety of intralesional injection of high concentration of bleomycin A5 for huge (more than 5 cm in diameter) macrocystic lymphatic malformations (LMs) in the cervical region. Thirty-two patients with huge macrocystic LMs were treated with percutaneous injection of bleomycin...
Article
Purpose: To investigate the therapeutic effects of pingyangmycin injection as a primary therapy of macrocystic lymphatic malformations in cervical region. Methods: Thirty-six patients with macrocystic lymphatic malformations in cervical region underwent the therapy of pingyangmycin injection between 2009 and 2012 at School of Stomatology, China...
Article
Purpose: To evaluate the clinical effect of using different concentrations of pingyangmycin to treat venous malformations in oral and maxillofacial region. Methods: One hundred and ninety-four patients with venous malformations in oral and maxillofacial region were included and treated by pingyangmycin injection with different concentrations. Fo...
Article
We investigated the clinical efficacy of propranolol in treating proliferating infantile haemangiomas, and the serological changes in vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) during treatment. Propranolol was given orally to 35 infants with proliferating haemangiomas in a dose of 1.0-1.5mg/kg/day. Hemis...
Article
The objective of this study was to summarize our experience of using local flaps for the reconstruction of neck defects after cervical contractures release, particularly of using the extended deltopectoral flaps whose distal margin was beyond the anterior axillary line even reaching dorsalis for reconstruction of anterior neck scar contractures in...
Article
To investigate the COX-2 depressant on cell apoptosis and angiogenesis of oral squamous cell carcinoma. RT-PCR and Western blotting were used to detect the effect of NS-398, the COX-2 inhibitor on mRNA and protein expression of VEGF and Survivin in oral squamous carcinoma cell line Tca8113. SPSS11.5 software package was used for statistical analysi...
Article
Objectives: This study was conducted to measure the soft tissue of the alar base and the piriform aperture area of the maxillary bone of unilateral cleft lips with secondary nasal deformities when secondary operation are necessary to classify the alar base depression and to provide a clinical reference for the second surgery. Methods: Twenty-six...
Article
The lip carcinoma, which frequently affects the lower lip, is one of the most common cancers of the head and neck region composing 25% to 30% of all oral cancers. The accepted method of therapy for lip cancer is surgical excision and reconstruction. The repair should satisfy 2 fundamental requirements: to achieve appropriate aesthetic quality and t...
Article
To investigate the clinical effect of electrochemical therapy (ECT) combined with pingyangmycin (PYM) injection for the treatment of high-return flow venous malformation. A total of 68 cases of the high-return flow venous malformation were retrospectively analyzed, in which 32 cases received simplely ECT,and 36 cases received ECT combined with PYM...
Article
To explore the therapeutic effect of electrochemical therapy(ECT) for high-flow vascular malformation in maxillofacial region. 38 patients with high-flow vascular malformation in maxillofacial region were treated with ECT. The voltage was 6-8 V, and the electric current was 80-100 mA. The electric quantity was 10-20 C/cm2. Among the 38 cases, 32 ca...
Article
To investigate the classification of alar base depression, so as to provide the reference for the surgical management of secondary nasal deformity of unilateral cleft lip. From Jul. 2008 to Feb. 2009, 26 cases with secondary deformity of unilateral cleft lip were treated. All the patients underwent 3-dimensional CT for maxillary measurement. The na...
Article
We explored the effect of electrochemical therapy for the treatment of high-flow venous malformations in the maxillofacial region in 32 patients. We used a method of anaesthesia that was suitable to the site and size of the lesion, and then inserted platinum needles into the lesion in a sterile environment. We protected the normal skin by inserting...
Article
To evaluate the clinical effect of using high concentration Pingyangmycin to treat vascular malformation in oral and maxillofacial region. One hundred and fourteen patients with venous malformation in oral and maxillofacial region (50 males and 64 females, age range: 12-76 years) were treated in our department from 2002 to 2008. The lesions ranged...
Article
To investigate the expression and correlation of mast cell, Clusterin/apoJ and transforming growth factor-beta (TGF-beta) in the different stages of human dermal hemangioma. Immunohistochemical stain technique (SABC) and toluidine blue (TB) stain technique were respectively used to detect the expression level of Clusterin/apoJ and TGF-beta and the...
Article
To study the therapeutic effect of one-staged repair of unilateral cleft lip an nasal deformity with modified Mohler. The unilateral cleft lip and nasal deformity were repaired in one stage with modified Mohler. The nasal retainers were kept for at least 6 months. The patients were followed up at 3 months and 12 months after operation. From Sept. 1...
Article
To study the feasibility and clinical effect of repairing important branches of facial nerve (zygomatic and marginal mandibular branches) with unimportant ones (upper buccal and cervical branches). The defect of zygomatic and marginal mandibular branches was repaired with upper buccal and cervical branches, respectively. After the length of facial...
Article
To investigate the effect of nHACP/CF on coherence and proliferation of osteoblast. The rat osteoblasts were isolated and cultured, then co-cultured with nHACP/CF in vitro. The cells were observed under cytochemical staining for ALP; the cell-material complex was observed under electronic scanning microscope, MTT was used for detection of cell prol...
Article
To investigate the relationship between cell apoptosis and regression process of hemangiomas. Fourty four hemangiomas and 19 vascular malformations, confirmed by pathology without any previous treatments were involved. Hemangiomas were classified into two groups by histological characters, among which 23 were in proliferating phase and 21 cases wer...
Article
Numerous methods have been developed for recording cleft lip and palate deformities, but none has been universally accepted due to limitations, inadequate description of the cleft deformities, and varying complexity. The classification system introduced in this article is designed to describe detailed information of the cleft deformities with five-...
Article
To investigate the inhibitive effect of COX-2 inhibitor NS-398 on cancer cell growth of human tongue squamous cell carcinoma. MTT assay was used to study the inhibitive effect of NS-398 on the growth of Tca8113 cells, and to investigate the time-effect relationship and dose-effect relationship between NS-398 and Tca8113 cells. The effect of NS-398...
Article
To determine expression of Cox-2 in oral squamous cell carcinoma (SCC) and oral leukoplakia and the relation to VEGF. Immunohistochemical staining was used to quantify Cox-2 and VEGF expressions in specimens from 48 patients with oral SCC (including 20 well differentiated cases, 16 moderately differentiated cases and 12 low differentiated cases), 3...
Article
To study a new method for repair of facial depression and facial nerve defect after parotid carcinoma reseciton. 12 patients with parotid carcinoma and peripheral bone invasion were treated using facial nerve canal dissection and radical resection of the tumor, the parotid gland and the involved facial nerve and bone, including the mastoid, styloma...
Article
To investigate the expression and function of the adhesion molecules ICAM-3, CD34 and HLA-DR antigen on endothelial cells of hemangiomas in different stages. SABC immunohistochemical technique was used to examine the expression of ICAM-3, CD34 and HLA-DR on vascular endothelial cells. Seventy-six specimens including 28 proliferating hemangiomas, 22...

Citations

... Herein, we found that the normal cartilage structure gradually becomes disordered and may disappear over a period after the fracture, and the degeneration of the subchondral bone becomes apparent. Then, the condyle is directly exposed to the glenoid fossa in the ICF+DD side at the advanced stage of PTOA, and the stress in the joint cavity changes, which in turn decreases the number of chondrocytes in the hypertrophic layer and thinning of this layer; Simultaneously, the number of cells in the proliferative layer is also decreased considerably, and the proliferative layer becomes thinner 21) . By analyzing the results of ICH, it was found that in the early stage of PTOA, Ihh and PTHLH/PTHrP were expressed in the cytoplasm of each layer of chondrocytes, but the expression was weaker than that in the control group. ...
... Usage and dosage: In China, commercially available 0.5% timolol maleate eye drops three times a day (6-8 h apart) is recommended. It is used by dropping the ophthalmic solution on absorbent cotton or one to two layers of gauze (30-40 μL/cm 2 ) to evenly soak the cotton or gauze, and applying to the lesion surface for 5-15 min, with the cotton or gauze, keeping it moist (95). Others also smear 0.25% or 0.5% timolol gel on the IH lesion two to three times a day, 3% propranolol gel on the IH lesion two to three times a day, or 2% carteolol hydrochloride drops twice a day. ...
... The incidence rate of male versus female was 1:3 ~ 1:5, and about 60% occurred in the head and neck [2]. Hemangiomas usually appear in the rst few days to one month postnatally and are characterized by small red spots in the early stage, then their volume increases rapidly, and they proliferated rapidly in the rst month and 4-5 months, reaching 80% of their nal volume [3]. After the age of 1 year, the natural regression process is beginning and can last 3 to 8 years or even longer. ...
... However, use of topical timolol for IH treatment is mainly based on clinical experience and evidence from observational studies, rather than randomized controlled trials (RCTs) . Combined therapy with topical timolol and oral propranolol has been proposed to be more effective for treating IHs compared to application of either component alone (Ge et al., 2016;Tong et al., 2016). However, clinical evidence to support this proposal remains limited. ...
... It can be mixed with natural polymers, as in the examples described above, and with synthetic polymers. In addition to biopolymers described above, the group of natural polymers with which the mixtures of silk fibroin were tested are gelatin [146][147][148], cellulose [149,150], agarose [151], keratin [152], elastin [153], chitin [154], heparin [155], and carrageenan [156]. They can be obtained as liquid states, films, 3D porous sponges, particles, and hydrogels, and they can be used in the broadly understood biomedical field. ...
... First of all, the experimental subjects are not easy to obtain. When many symptomatic patients feel the symptoms, IDD has developed to a very serious degree (5)(6). Secondly, IDD is a process of slow progress, and the experimental period that needs observation and research will be very long, which is not conducive to the achievement of transformation (7)(8). ...
... In many cases, these lesions are not clearly visible on the skin. [17][18][19] In general, they do not change during crying or Valsalva maneuvers, as is the case with VMs. ...
... Thus, Wang et al. reported the usefulness of porous Col1/nHA scaffolds for restoration of critical-size bone defects [217]. Bioactive molecules like Col1 and CS have also been used as composite components for regeneration of bone tissue [218][219][220][221][222]. ...
... It was observed that the mean time duration to resolution was evidently shorter with prominent color fading in the experimental group over the control. [13] Deep hemangiomas in 5 subjects in a study were treated with topical timolol 0.5% solution alone as three drops three times a day. Complete regression was noticed after about 10 months. ...
... It was necessary to estimate the toxicity of the obtained SeB-NPs and Ag SeB-NPs for further tissue engineering applications. Osteoblasts were commonly used to evaluate the cytocompatibility of nanoparticles and/or scaffold in tissue engineering 58,59 . In this study, the cytocompatibility of SeB-NPs and Ag SeB-NPs was assessed by culturing with hFOB 1.19 cells. ...