Xiyang Zhang's research while affiliated with Sichuan University and other places

Publications (4)

Article
Objective: To explore the protective effect of sodium channels antagonists HOE642 on lung ischemia reperfusion and the role of the p38 mitogen activated protein kinase (p38MAPK) signaling pathway in this process. Methods: A total of 36 mice were randomly divided into a sham operation group (SHAM group), a lung ischemia reperfusion group (I/R grou...
Article
Full-text available
Remote ischemic preconditioning (RIPC) may attenuate acute kidney injury (AKI). However, results of studies evaluating the effect of RIPC on AKI after cardiac surgery have been controversial and contradictory. The aim of this meta-analysis is to examine the association between RIPC and AKI after on-pump cardiac surgery. The authors searched relevan...
Article
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Citations

... The no-treatment group 0.40 ± 0.021 The control group 0.10 ± 0.020 The treatment group 0.34 ± 0.015 apoptosis of chondrocytes was inhibited, and the further cartilage recovery was promoted but also the generation of inflammatory factors was inhibited and the progression of the disease was delayed Shunzhi et al., 2017;Deng et al., 2017). Both the Notch pathway and the chondrocyte apoptosis have played key roles in the development of cartilage defects, which regulate multiple procedures in the development of osteoblasts, including the differentiation and proliferation of osteoblasts and the functions of osteoclasts; in addition, they also regulate cartilage production during the process of development and homeostasis. ...
... The different patterns observed in the muscle and in remote organs are possibly related to the underlying mechanisms of RIC. Longer cycles are necessary to activate different pathways supposed to be related to this technique and to evoke a protective effect in distant tissues, for instance, a neural pathway, in which sublethal ischemic stimulus provides an afferent signal to the central nervous system 16,20,21 . Consequently, there is an efferent response, through activation of parasympathetic nerves, that plays a role in modulating vascular activity and increasing antiinflammatory substances 16 . ...