Xixun Yu’s research while affiliated with Sichuan University and other places

... Glutaraldehyde (GA) cross-linked collagen improved collagen's thermal stability and anti-enzyme activity. Nonetheless, GA posed potential risks of cytotoxicity and calcification [17,18]. The process of cross-linking involving 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) bolstered the mechanical resilience of collagen. ...

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Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation

... The incorporation of MoS 2 into composite materials enhances the mechanical strength of the scaffolds, thus offering crucial structural reinforcement for tissue regeneration. 18 The studies have proven the composites of polycaprolactone-MoS 2 , 19 polycaprolactone-MoS 2 nanofiber, 20 polyacrylonitrile-MoS 2 , 21 MoS 2 nanosheet-polycaprolactone/zein, 18 MoS 2 -hydroxyapatite, 22 alginate-casein-MoS 2 , 23 polycaprolactone-polylactide-co-glycolide-bioactive glass-MoS 2 nanoparticles, 24 MoS 2 -metformin, 25 poly(lactic-coglycolic) acid-simvastatin-mesoporous bioactive glass-MoS 2 , 26 and MoS 2 -bioactive borosilicate glass 27 have shown better biocompatibility, biodegradability, enhanced alkaline phosphatase (ALP), and increased bone mineralization when compared with the control. Hence, the addition of MoS 2 in the composite system significantly increases the overall biocompatibility of the scaffold. ...

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Enhanced Bioactivity of Chitosan-Alginate-Riboflavin Liquid-Exfoliated Molybdenum Disulfide Nanosheets for Bone Tissue Engineering Applications

... Many hydrogels incorporate bioactive molecules that promote cell proliferation and differentiation, such as growth factors (Jain et al., 2019), or provide physical support to facilitate new cartilage formation (Yang et al., 2023). For example, Cheng et al. (2023) developed a double-network hydrogel with antibacterial and anti-inflammatory properties, enhancing cartilage repair by incorporating allicin and decellularized cartilage powder. Similarly, Chen et al. (2024) designed a nanocomposite hydrogel with poly (gallic acid)-manganese (PGA-Mn) nanoparticles, which strengthens the hydrogel while scavenging ROS, protecting chondrocytes from oxidative stress. ...

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Antioxidant hydrogels for the treatment of osteoarthritis: mechanisms and recent advances

... Decellularization is an emerging biomaterial preparation method in tissue engineering [17], which involves the removal of cellular components from biological tissues or organs to obtain a protein matrix for cell growth [18], which is ideal raw material for the preparation of wound dressings [19]. In many current studies on tissue regeneration, decellularized matrices of cardiac origin are attractive because they retain key molecules for wound healing, such as collagen, elastin, fibronectin and pro-angiogenic factors (ANG-1, ANG-3, CCN1, FGF-1, FGF-2, leptin, MMP-9, NOV, SDF-1 and VEGF -β) [20], which not only accelerates wound re-epithelialization to accelerate wound closure [21], but also improves healing quality by increasing collagen deposition and maturation. ...

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Porcine pericardial decellularized matrix bilayer patch containing adipose stem cell-derived exosomes for the treatment of diabetic wounds

... The result is consistent with the literature. 28,29 The C2-C3 linkage was cleaved in the N-acetyl-glucosamine unit (GlcN) and dialdehyde was formed. ...

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Stimuli-responsive chitosan-based injectable hydrogel for “on-demand” drug release

... The hemocompatibility of valve prostheses is crucial for their clinical application. Previous studies have employed numerous modification strategies to mitigate the biofouling of blood constituents and enhance the hemocompatibility of valves [36][37][38][39]. In the present study, we modified dECM with an RBCM coating to enhance its hemocompatibility. ...

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Large-Scale Surface Modification of Decellularized Matrix with Erythrocyte Membrane for Promoting In Situ Regeneration of Heart Valve

... The most common method to modify and introduce aldehyde or ketone groups into polysaccharides is via oxidative cleavage of vicinal diols driven by sodium periodate (NaIO 4 ) [117,118]. Muhammad et al. [88] evaluated the effect of reaction time and sodium periodate (NaIO 4 ) concentration on the degree of oxidation of alginate and hyaluronic acid. These polysaccharides can yield in situ gelling hydrogels to be used in drug delivery systems by imine bond formation. ...

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Crosslinking Methods in Polysaccharide-Based Hydrogels for Drug Delivery Systems

... Besides, DCDs possess abundant reducing groups, which can scavenge ROS and promote the phenotype switching of macrophages from M1-type to M2-type, which is favorable for suppressing inflammatory responses. 80 Manipulation of BMSCs differentiation is becoming an essential aspect of bone regeneration. Shao and his colleagues demonstrated that CDs can promote the osteogenic differentiation of BMSCs for the first time. ...

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Carbon dots‐based materials and their applications in regenerative medicine

... It has been found that RES stimulates the production of collagen III and improves the proliferation and migration of human gingival fibroblasts (72). Oxidized NAR exhibited good cytocompatibility and could promote the secretion of growth factors by fibroblasts (73). ...

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Antimicrobial efficiency and cytocompatibility of resveratrol and naringin as chemical decontaminants on SLA surface

... TA increases the mechanical strength, decreases the excessive swelling rate, and promotes the adherence of the hydrogel to various substrates. According to Cheng et al., the combination of PVA and agar loaded with tannic acid presented promising characteristics in terms of hemostatic, antibacterial activity, cytocompatibility, and rapid wound healing [34]. Finally, the composite hydrogel developed in this study can effectively be applied in crucial areas such as artificial cartilage. ...

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Enhancement of Mechanical Properties of Benign Polyvinyl Alcohol/Agar Hydrogel by Crosslinking Tannic Acid and Applying Multiple Freeze/Thaw Cycles