March 2025
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2 Reads
Nano Energy
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March 2025
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2 Reads
Nano Energy
December 2024
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24 Reads
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1 Citation
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis, bone‐erosion, and joint‐destruction. Here, we developed a locally injectable, ROS‐scavenging, and ROS‐/pH‐responsive drug‐delivery platform (HC@PTM) by bio‐compositing of aldolizing hyaluronic acid (HA) crosslinked with chitosan (CS), and ROS‐triggered/eliminated micelles (PTM) coupled with the drug methotrexate(MTX). The PTM efficiently eradicate excessive ROS in RA‐joints, precisely triggering drug‐release within inflamed arthritic‐sites and further confer exceptional antioxidant origins to HC@PTM. HC@PTM with outstanding shape‐adaptability and self‐repairing properties effectively conformed to irregular articular cartilage while resisting joint‐induced deformations. Further, the platform's pH‐responsive nature enables on‐demand drug‐release within acidic inflamed synovium, serving as a drug‐reservoir for precise and sustained therapeutic effects. Extensive in vitro and in vivo investigations confirm HC@PTM's ability to induce M2 macrophage polarization, downregulate inflammatory factor expression, and ameliorate the RA‐microenvironment, ultimately achieving synergistic therapeutic outcomes. This study represents significant advancements in precise and long‐term RA‐treatment through a minimally invasive approach, offering potential strategies for novel precision medicine.
December 2024
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13 Reads
Journal of Hazardous Materials
November 2024
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22 Reads
Trends in Biotechnology
October 2024
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20 Reads
Chemical Engineering Journal
August 2024
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10 Reads
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1 Citation
Distorted urea levels indicate several liver, kidney, or metabolic diseases; however, traditional clinical urea detection relies on urease‐based methods enslaved to well‐known limitations of high‐price, unstable properties, complicated sample pretreatment and analysis procedures, and difficult visual real‐time monitoring. Herein, nonenzymatic paper‐based fluorescent materials (UFP‐BP) are strategically integrated with an on‐demand fluorescent‐sensor (UFP) self‐aggregated nanoparticle on commercial filter paper for pre‐dilution‐free and visual real‐time urea monitoring. The UFP is synthesized and self‐aggregated into the fluorescent nanoparticles for selective urea recognition. Then, the nanoparticles are interstitially loaded on filter paper to nanoengineer the UFP‐BP, achieving selective quantitative urea detection in the normal concentration range (10–1000 mm). UFP and UFP‐BP can successfully monitor urea levels in real rat urine, artificial simulants, and milk. The proposed sensing platform, integrated with smartphones, offers accurate, quantitative, nonenzymatic, noninvasive, pre‐dilution‐free, on‐site, rapid, low‐cost, easy‐to‐operate, real‐time visual urea detection in food samples and human body fluids. The designed sensing system can provide early warnings of abnormal nitrogen‐based health issues.
July 2024
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9 Reads
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1 Citation
Journal of Environmental Management
July 2024
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21 Reads
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3 Citations
Journal of Material Science and Technology
July 2024
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10 Reads
June 2024
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12 Reads
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2 Citations
International Journal of Biological Macromolecules
... In line with the pursuit of environmentally friendly alternatives, recent developments in multifunctional chitosan-based tanning agents derived from biomass, such as enoki mushroom roots, have demonstrated significant potential in reducing the environmental impact of traditional leather tanning processes. These agents offer chrome-free tanning solutions with excellent tanning, dyeing, and antimicrobial properties, while simplifying the tanning process and minimizing wastewater pollution [14]. The sustainability assessment, including LCA and efficiency indicators, demonstrated that the optimized design outperformed the base case regarding water management, process efficiency, and sustainability footprint despite slightly higher costs associated with the water regeneration network installation. ...
June 2024
International Journal of Biological Macromolecules
... Its structural integrity, biodegradability, and functional additives like quercetin provide UV shielding, antimicrobial effects, and real-time food spoilage monitoring. The novel film extends food shelf life by 5 days, outperforming polyethylene (PE) packaging by 2 days, while advancing sustainable packaging design capabilities (Jiang et al., 2024). ...
June 2024
Nano Today
... High crosslinking efficiency and ecofriendliness 75 -80 °C (Wang et al. 2024) Effective in improving shrinkage temperature. Silica-based tanning Imparts better mechanical properties. ...
April 2024
International Journal of Biological Macromolecules
... 44,45 In addition, TENGs can be integrated into human clothing, insoles, and other wearable locations to harvest mechanical energy from body movements, providing power for various monitoring sensors. 16,[46][47][48][49][50] Previous studies indicate that most triboelectric materials used in TENGs are commercial or synthetic composite materials, which, although exhibiting excellent electricity-generating properties, are often associated with high costs. 51,52 While composite materials generally exhibit superior electrification properties, they pose challenges in mass production and incur high costs. ...
April 2024
... Therefore, Bio-inspired synthesis is a promising approach to overcoming obstacles owing to nature's diversity [206]. Biopolymers are produced through chemical synthesis or fermentation from bioresources [207]. The process of directly extracting biopolymers from bioresources such as cellulose, lignin, lipids, proteins, and starch is known as biopolymer extraction [208,209]. ...
January 2024
... Respiratory transmission is an important route for bacteria, mycoplasma, viruses, and other pathogens to infect humans. Therefore, wearing personal protective equipment is an effective method to reduce damage to the human body from harmful gases, droplets, viruses, and other substances [6,7]. As a simple and cost-effective method, wearing a mask can effectively limit the spread of disease. ...
October 2023
Chemistry of Materials
... Chronic wounds, often complicated by factors such as diabetes, pose a substantial challenge for existing wound dressings. Smart wearables promote the healing process through electrical and mechanical stimulation 29,30 and the on-site monitoring of relevant biomarkers [31][32][33][34][35] to track healing progress and inflammation. They encompass features such as drug delivery, electrical stimulation and photodynamic therapy, actively adjusting drug release to adapt to the changing wound environment 36 . ...
October 2023
Nano Energy
... The sensing and transformation process of skin-like sensors relies on measuring a range of electrical properties such as resistance, capacitance, voltage, and impedance. 72 For instance, wearable temperature sensors based on various sensing mechanisms such as resistance changes induced by thermal expansion, 73 capacitance changes induced by alterations in dielectric constants, 74,75 and the thermochromic effect and more, 76,77 have been developed. These temperature sensors are crucial for monitoring physiological activities as temperature is a fundamental parameter. ...
September 2023
... In the field of food safety, meat spoilage is a serious problem today. Extended storage of meat can lead to microbial enzymatic reactions, specifically the decarboxylation of amino acids and the amination of chemical molecules containing carbonyl groups [2]. Thus, the degradation of food can be easily recognised by detecting NH 3 . ...
August 2023
... Furthermore, some other "X-in-one" post-tanning processes including retanning, filling, dyeing, and fatliquoring have been proposed and investigated. For instance, acrylic acid (AA), diallyl dimethyl ammonium chloride (DMDAAC), dodecyl acrylate (DA), and 1,8-naphthalic anhydride (NA), were employed to prepare an amphoteric polymer (labeled as pADD-DMENA) for successfully achieving the high-performance retanning, fatliquoring, and dyeing of Cr-free organic tanned leather [28]. The pADD-DMENA treated leather had a bright yellow color surface with high uniformity, superior lightfastness, durability, and washability. ...
January 2023
Green Chemistry