Xinguang Yu's research while affiliated with Nankai University and other places

Publications (135)

Article
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Introduction Stress‐related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to explore the effects of excessive cortisol on hippocampus as...
Article
Intracranial brain-computer interfaces (BCIs) can assist severely disabled persons in text communication and environmental control with high precision and speed. Nevertheless, sustainable BCI implants require minimal invasiveness. One of the implantation strategies is to adopt localized and robust cortical activities to drive BCI communication and...
Article
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To report for the first time the preliminary results for the evaluation of a VRR-LRR™ analyzer based on visible resonance Raman technique to identify human meningioma grades and margins intraoperatively. Unprocessed primary and recurrent solid human meningeal tissues were collected from 33 patients and underwent Raman analysis during surgeries. A t...
Article
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Background Primary spinal pilocytic astrocytoma (PA) is an extremely rare low-grade astrocytoma with unclear natural history. The demographic characteristics, imaging features, and long-term surgical outcomes have not been clarified due to low prevalence and limited reports. Methods A retrospective review within a single institution between 2004 a...
Article
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Cortisol, the end product of the hypothalamic–pituitary–adrenal axis, regulates cognitive function and emotion processing. Cushing's disease, which is characterized by a unique excess of cortisol upon clinical diagnosis, serve as an excellent in vivo “hyperexpression” model to investigate the neurobiological mechanisms of cortisol in the human brai...
Article
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Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patients. To better understand the crosstalk between SE...
Article
MRgFUS has just been made available for the 1.7 million Parkinson's disease patients in China. Despite its non-invasive and rapid therapeutic advantages for involuntary tremor, some concerns have emerged about outcomes variability, non-specificity, and side-effects, as little is known about its impact on the long-term plasticity of brain structure....
Article
Cervical and thoracic or lumbar intramedullary spinal cavernous malformations (ISCMs) may behave differently. We conducted this retrospective study by using data from adult ISCMs to compare their natural histories and explore prognostic factors for improved clinical outcomes. Neurological functions were assessed by using the Modified McCormick Scal...
Preprint
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Communicating tumors between the posterior fossa and parapharyngeal space are rare and difficult to diagnose and treat. Surgical excision of these space lesions is challenging because of the anatomical complexity of the area. In this case we successfully made full resection of a big rare vagus nerve schwannoma at cerebellopontine angle and paraphar...
Article
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A growing body of evidence suggests that altered brain structure plays a crucial role in the pathogenesis of neuropsychological abnormalities induced by hypercortisolism in patients with Cushing’s disease (CD). While most studies mainly focus on gray matter, white matter structure has been largely overlooked. In the current study, we conducted a cr...
Article
Few in vivo studies have focused on the perivenous association of tubers and iron deposition in the deep gray nuclei in patients with tuberous sclerosis complex (TSC). We investigated this possible relationship in TSC patients using susceptibility weighted imaging (SWI) at 7 T. SWI with high spatial resolution and enhanced sensitivity was performed...
Article
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Purpose: Hemangiopericytomas are aggressive tumors known for their recurrence. The purpose of this study was to evaluate the management of residual, recurrent, and metastatic intracranial hemangiopericytomas using CyberKnife (CK) stereotactic radiotherapy (SRT). Materials and methods: Data were collected from 15 patients (28 tumors; eight men an...
Article
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Good outcomes have been reported in deep brain stimulation (DBS) for myoclonus-dystonia syndrome (M-D), a heritable disease characterized by childhood-onset myoclonic jerks and dystonia in the upper body. This meta-analysis was to evaluate the clinical outcomes consecutively, compare the stimulation targets, and identify potential prognostic factor...
Article
Background Cortisol has long been considered to play a crucial role in the pathogenesis of stress-related disorders. Cushing’s disease (CD) provides an excellent “hyperexpression model” to investigate the chronic effects of cortisol on brain physiology and cognition. Previous studies have shown that cortisol is associated with neurophysiological al...
Article
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One biomarker for a better therapeutic effect of immune checkpoint inhibitors is high expression of checkpoint in tumor microenvironment The purpose of this study is to investigate the expression of immune checkpoints in human glioma microenvironment and peripheral blood mononuclear cells. First, single-cell suspension from 20 fresh high-grade glio...
Article
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PurposePediatric intramedullary spinal cord cavernous malformation (ISCM) is a rare vascular disease with unclear natural history and long-term outcomes. We aim to determine the demographics, hemorrhagic risk, and long-term outcomes of this rare entity.MethodsA retrospective review of clinical data and treatment outcomes of pediatric patients treat...
Article
Poor response of human glioblastoma to current therapies are influenced by tumor microenvironment. Although glioblastoma is recognized by large enrichment of microglia, characterization of diverse cell subsets and their functions remain challenging because of high heterogenicity. Here, we analyzed single-cell transcriptomics to comprehensively map...
Article
Medulloblastoma (MB) with metastases at diagnosis and recurrence correlates with poor prognosis. Unfortunately, the molecular mechanism underlying metastases growth has received less attention than primary therapy-naïve MB. Though astrocytes have been frequently detected in brain tumors, their roles in regulating the stemness properties of MB stem-...
Article
Full-text available
Background Pure spinal epidural cavernous malformation (CM) is a rare hypervascular disease that is easily misinterpreted as other imaging-similar epidural lesions. The demographic characteristics, therapeutic strategies, and surgical outcomes associated with this vascular entity remains unclear.MethodsA retrospective review of patients with pathol...
Article
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BACKGROUND With infiltration, high-grade glioma easily causes the boundary between tumor tissue and adjacent tissue to become unclear and results in tumor recurrence at or near the resection margin according to the incomplete surgical resection. Fourier transform infrared spectroscopy (FTIR) technique has been demonstrated to be a useful tool that...
Article
In the interaction between a tumor and the immune system, immune checkpoints play an important role, and in tumor immune escape, co-inhibitory immune checkpoints are important. Immune checkpoint inhibitors (ICIs) can enhance the immune system's killing effect on tumors. To date, impressive progress has been made in a variety of tumor treatments; PD...
Article
Purpose Epileptic seizures often develop in 40-70% of glioma patients and have a significant impact on patients’ quality of life. Many biomarkers have been suggested to be associated with glioma-related preoperative seizures (GPS). The purpose of the present study was to investigate the possible correlation between GPS and clinicopathological facto...
Article
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Background Glioma invading the corpus callosum (CC) accounts for approximately 14% of gliomas and is thought to be more aggressive. However, there is still a lack of studies on the pathogenesis and molecular features of this condition. Here, we examined the occurrence association of CC invasion with respect to patients’ clinical, pathological, and...
Article
Background Competing endogenous RNA (ceRNA) networks play a pivotal role in tumor diagnosis and progression. Numerous studies have explored the functional landscape and prognostic significance of ceRNA interaction within differentiated tumor cells. Objective We propose a new perspective by exploring ceRNA networks in the process of glioblastoma st...
Article
Spinal dural arteriovenous fistula (dAVF) is an extremely rare vascular entity that is usually misdiagnosed. We sought to determine the long-term clinical outcomes of patients undergoing microsurgical treatment for delayed diagnosis of spinal dAVF. This retrospective study identified patients with delayed diagnosed spinal dAVF at our institution fr...
Preprint
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Background: Transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) surgery is a noninvasive thermal ablation therapy for neurological conditions such as essential tremor (ET). However, most studies on the therapeutic mechanisms of this technique are limited to the visualization of brain structure and network activities with resting st...
Article
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Background Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique for Alzheimer’s disease (AD). rTMS, with high- or low-frequency, is thought to enhance or inhibit the cortical activities, respectively. This meta-analysis of randomized controlled trials (RCTs) was to summarize the efficacy of the rTMS on th...
Article
Objective: The 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) was revised to include molecular biomarkers as diagnostic criteria. However, conventional biopsies of gliomas were spatially and temporally limited. This study aimed to determine whether circulating tumor DNA (ctDNA) from cerebrospinal...
Article
Objective: Primary cervical dystonia (CD) is characterized by abnormal contractions of neck muscles. Globus pallidus internus deep brain stimulation (GPi-DBS) is recognized as an effective therapy for patients with refractory CD, but the prognostic factors need further research. Our study investigated the predictive factors of clinical outcomes in...
Article
Objective This meta-analysis aimed at evaluating and comparing the efficacy of noninvasive brain stimulation (NIBS) techniques on the behavioral and psychological symptoms of dementia (BPSD). Methods An exhaustive literature retrieval was performed on PubMed, Embase, Cochrane Library, and Web of Science until October 2019. The primary outcome was...
Conference Paper
Machine learning algorithms were used to classify and analyze spectral data collected by visible resonance Raman spectroscopy to distinguish normal human brain tissue and glioma tumor tissues at different grades and show promising results.
Article
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Neuroimaging studies have shown that chronic pain is maladaptive and influences brain function and behavior by altering the flexible cerebral information flow. We utilized power spectral analysis to investigate the impact of classic trigeminal neuralgia (TN) on the oscillation dynamics of intrinsic brain activity in humans. The amplitude of low-fre...
Article
Background: Medulloblastoma (MB) with metastases at diagnosis and recurrence correlates with poor prognosis. Unfortunately, the molecular mechanism underlying metastases growth has received less attention than primary therapy-naïve MB. Though astrocytes have been frequently detected in brain tumors, their roles in regulating the stemness propertie...
Article
Full-text available
Background Deep brain stimulation (DBS) is an effective intervention for Meige syndrome, a type of dystonia characterized by blepharospasm, facial, and oromandibular dystonia. This individual patient-level data meta-analysis was to identify the potential outcome predictors, compare the stimulation targets and summarize the efficacy of DBS for Meige...
Article
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Glioma is one of the most refractory types of brain tumor. Accurate tumor boundary identification and complete resection of the tumor are essential for glioma removal during brain surgery. We present a method based on visible resonance Raman (VRR) spectroscopy to identify glioma margins and grades. A set of diagnostic spectral biomarkers features a...
Article
Recurrent glioblastomas are frequently found near subventricular zone (SVZ) areas of the brain where neural stem cells (NSCs) reside, and glioblastoma-derived extracellular vesicles (EVs) are reported to play important roles in tumour micro-environment, but the details are not clear. Here, we investigated the possibility that NSCs are involved in g...
Article
BACKGROUND CONTEXT Patients with basilar invagination (BI) and atlas occipitalization usually present abnormal anatomy of the vertebral arteries (VAs) at the craniovertebral junction (CVJ). PURPOSE To describe and further classify different types of VA variations at the CVJ with 3D visualization technology. STUDY DESIGN/SETTING To display the 3D...
Article
BACKGROUND CONTEXT Surgery planning of the C1-2 dislocation with and basilar invagination and occipitalization has changed significantly with the advent of 3D virtual techniques. However, it is still limited by its dependence on computer workstations, its lack of tactile experience and the inability to simulate surgical procedures and interventions...
Article
Flexible and stretchable strain sensors are essential components of smart wearable devices for monitoring human activities. Such sensors have been extensively exploited with various conductive materials and structures, which, however, are normally in need of complex manufacturing processes and confronted with the challenge to achieve both large str...
Article
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Purpose To explore the anatomical distance-dependent functional connectivity patterns in patients with active phase of Cushing’s disease (CD) and to evaluate the associations between hypercortisol exposure and regional normalized functional connectivity strengths (nFCSs). Methods Based on the fMRI data in 32 CD patients and 32 healthy controls (HC...
Article
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Background Although intracerebral hemorrhage is the most feared complication of deep brain stimulation (DBS) surgery, cerebral ischemic events in association with DBS surgery have only rarely been described. We therefore evaluated the role of intraoperative MRI (iMRI) for early identification of cerebral ischemic events during DBS procedures and de...
Article
The aim of the present study was to investigate the efficacy of endoscopic surgery via a Kocher point approach for intraventricular hemorrhage (IVH) caused by thalamic hemorrhage (TH), in comparison with external ventricular drainage (EVD). Between January 2016 and August 2017, a total of 40 patients with IVH caused by TH were enrolled. The patient...
Article
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Background: Glioma-related epilepsy (GRE) is defined as symptomatic epileptic seizures secondary to gliomas, it brings both heavy financial and psychosocial burdens to patients with diffuse glioma and significantly decreases their quality of life. To date, there have been no clinical guidelines that provide recommendations for the optimal diagnost...
Article
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Background Deep brain stimulation (DBS) can be an effective therapy for tics and comorbidities in select cases of severe, treatment-refractory Tourette syndrome (TS). Clinical responses remain variable across patients, which may be attributed to differences in the location of the neuroanatomical regions being stimulated. We evaluated active contact...
Article
Background: The effect of intraoperative magnetic resonance imaging (iMRI) on tumor control during endoscopic transsphenoidal surgery (TSS) for nonfunctioning pituitary adenomas (NFPAs) has not yet been completely characterized. The present study assessed the effect of the iMRI findings on gross total resection (GTR) and progression-free survival...
Article
OBJECTIVE Primary Meige syndrome is characterized by blepharospasm and orofacial–cervical dystonia. Deep brain stimulation (DBS) is recognized as an effective therapy for patients with this condition, but previous studies have focused on clinical effects. This study explored the predictors of clinical outcome in patients with Meige syndrome who und...
Article
Although the general balloon occlusion test (BOT) is commonly used, there is limited information on the evaluation standards and methodological protocols for the superselective BOT, which may be required in some special aneurysm cases. We performed the superselective BOT in 12 patients with specific complex aneurysms and report our experiences here...
Data
Schematic illustration of the literature search and study selection criteria.
Data
STN-subthalamic nucleus, GPi-internal globus pallidus, Vim-ventral intermediate nucleus, PPN-pedunculopontine nucleus, MT-medical therapy, sd-standardized mean.
Data
Evidence network for different DBS (Deep brain stimulation) targets. STN, subthalamic nucleus; GPi, internal globus pallidus; Vim, ventral intermediate nucleus; PPN, pedunculopontine nucleus; MT, medical therapy.
Article
Full-text available
Background: Deep brain stimulation (DBS) is considered an effective treatment option for Parkinson's disease (PD). Several studies have demonstrated the efficacy of neurostimulation in patients with advanced PD. The subthalamic nucleus (STN), the internal globus pallidus (GPi), ventral intermediate nucleus (Vim), and pedunculopontine nucleus (PPN)...
Article
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Objective To evaluate the efficacy and safety of hypofractionated stereotactic radiotherapy using CyberKnife for high volume cavernous sinus cavernous hemangiomas. Materials and Methods We collected data from 12 patients with high volume cavernous sinus cavernous hemangiomas treated with hypofractionated stereotactic radiotherapy using CyberKnife...
Conference Paper
A VRR-LRR analyzer with handheld fiber‐optic probe is reported for the first time for diagnosis of brain GBM in vivo. The sensitivity for identification is 80% compared with histopathology examination.
Article
Objective: The aim of this study was to analyze the expression profiles of long non-coding RNA (lncRNAs) in human mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) and to detect the functions of lncRNAs in epileptogenesis in MTLE. Materials and methods: We used microarray analysis to analyze the differential expression of lncR...
Article
Full-text available
The accurate identification of the human brain tumor boundary and the complete resection of the tumor are two essential factors for the removal of the glioma tumor in brain surgery. We present a visible resonance Raman (VRR) spectroscopy technique for differentiating the brain tumor margin and glioma grading. Eighty-seven VRR spectra from twenty-on...
Article
Delayed cerebral vasospasms (DCVS) may affect the prognosis of patients after subarachnoid hemorrhage (SAH), but available preventive approaches are inefficient. The objective of this study was to explore the effects of cardamonin treatment on factors associated with the occurrence of DCVS after SAH. Rat models of SAH were created using the interna...
Poster
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Tourette syndrome (TS) is a complex neurodevelopment disorder characterized by involuntary movements and vocalizations, or tics. It is commonly associated with obsessive-compulsive behavior (OCB). Deep brain stimulation (DBS) has been explored as a potential therapy for select cases of TS with severe, treatment-refractory symptoms. Several nuclei h...