November 2024
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4 Reads
Carbohydrate Polymers
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November 2024
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4 Reads
Carbohydrate Polymers
September 2024
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3 Reads
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2 Citations
International Journal of Biological Macromolecules
September 2024
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6 Reads
International Journal of Biological Macromolecules
July 2024
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18 Reads
Molecules
Liver disease is a global health problem that affects the well-being of tens of thousands of people. Dihydroquercetin (DHQ) is a flavonoid compound derived from various plants. Furthermore, DHQ has shown excellent activity in the prevention and treatment of liver injury, such as the inhibition of hepatocellular carcinoma cell proliferation after administration, the normalization of oxidative indices (like SOD, GSH) in this tissue, and the down-regulation of pro-inflammatory molecules (such as IL-6 and TNF-α). DHQ also exerts its therapeutic effects by affecting molecular pathways such as NF-κB and Nrf2. This paper discusses the latest research progress of DHQ in the treatment of various liver diseases (including viral liver injury, drug liver injury, alcoholic liver injury, non-alcoholic liver injury, fatty liver injury, and immune liver injury). It explores how to optimize the application of DHQ to improve its effectiveness in treating liver diseases, which is valuable for preparing potential therapeutic drugs for human liver diseases in conjunction with DHQ.
June 2024
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2 Reads
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1 Citation
International Journal of Biological Macromolecules
June 2024
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6 Reads
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1 Citation
April 2024
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11 Reads
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3 Citations
Carbohydrate Polymers
April 2024
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7 Reads
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6 Citations
International Journal of Biological Macromolecules
March 2024
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8 Reads
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3 Citations
Heliyon
Abscisic acid (ABA) is a plant hormone with various biological activities. Aging is a natural process accompanied by cognitive and physiological decline, and aging and its associated diseases pose a serious threat to public health, but its mechanisms remain insufficient. Therefore, the purpose of this study was to investigate the ameliorative effects of ABA on d-galactose (D-Gal)-induced aging in mice and to delve into its molecular mechanisms. Aging model was es-tablished by theintraperitoneal injection of D-Gal. We evaluated the oxidative stress by measuring superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT) levels in serum. Proteins content in brain were determined by Western blot. D-Gal-induced brain damage was monitored by measuring the levels of acetylcholinesterase (AChE) content and hematoxylin-eosin staining (H&E). To evaluate the effects of ABA on aging, we measured the gut microbiota. The results demonstrated that ABA increased SOD, CAT and AChE, decreased MDA level. H&E staining showed that ABA could improve D-Gal-induced damage. In addition, ABA regulated the B-cell-lymphoma-2 (BCL-2) family and Phosphatidylinositol 3-kinase/Protein kinase B (PI3K/AKT) signaling pathway, while further regulating the acetylation of p53 protein by modulating the AMPK pathway and activating SIRT1 protein, thereby inhibiting the apoptosis of brain neurons and thus regulating the aging process. Interestingly, ABA improved the ratio of intestinal bacteria involved in regulating multiple metabolic pathways in the aging process, such as Bacteroides, Firmicutes, Lactobacillus and Ak-kermansia. In conclusion, the present study suggests that ABA may be responsible for improving and delaying the aging process by enhancing antioxidant activity, anti-apoptosis and regulating intestinal flora.
February 2024
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8 Reads
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1 Citation
Molecules
Chemotherapy is a well-established method for treating cancer, but it has limited effectiveness due to its high dosage and harmful side effects. To address this issue, researchers have explored the use of photothermal agent nanoparticles as carriers for precise drug release in vivo. In this study, three different sizes of polydopamine nanoparticles (PDA–1, PDA–2, and PDA–3) were synthesized and evaluated. PDA–2 was selected for its optimal size, encapsulation rate, and drug loading rate. The release of the drug from PDA–2@TAX was tested at different pH and NIR laser irradiation levels. The results showed that PDA–2@TAX released more readily in an acidic environment and exhibited a high photothermal conversion efficiency when exposed to an 808 nm laser. In vitro experiments on ovarian cancer cells demonstrated that PDA–2@TAX effectively inhibited cell proliferation, highlighting its potential for synergistic chemotherapy-photothermal treatment.
... These results demonstrate the efficacy of the PTH hydrogel in promoting wound healing and its ability to reduce oxidative stress. 98 Category 2: optimizing diabetic wound healing-targeted therapies for angiogenesis, collagen deposition, and inflammation management Targeted therapies that promote angiogenesis, collagen deposition, and reduce inflammation have emerged as promising strategies to enhance diabetic wound healing. In addressing these pivotal elements, researchers endeavor to enhance the outcomes of diabetic foot ulcers and alleviate the complexities linked to hindered wound recovery in individuals with diabetes. ...
April 2024
International Journal of Biological Macromolecules
... ○ Thin film hydration [ 221,[237][238][239] ○ Reverse phase evaporation [ 221,237,240] ○ Ethanol injection [ 221,237,241] ○ Detergent removal [ 221,237] • Active or remote loading (after liposome formation): ...
April 2024
Carbohydrate Polymers
... Abscisic acid, as a natural plant hormone existing in a variety of plant and animal tissues, has significant pharmacological activities, including anti-inflammatory effects, which can alleviate the occurrence and development of various diseases [30,[174][175][176][177][178]. In addition, studies have shown that ABA can improve and delay aging by enhancing antioxidant activity, anti-apoptosis, and regulating intestinal flora [179]. ...
March 2024
Heliyon
... Insulin hydrogel dressing showed therapeutic effects in diabetic in vivo model with complete thickness wounds by reducing the duration of inflammation, promoting tissue granulation, encouraging the adhesion of collagen, hastening in neovascularization and epithelialization and possibly improving peripheral neuropathy. Hence, the insulin hydrogel has promising potential in wound dressings for improving DFU [74,75]. ...
February 2024
International Journal of Biological Macromolecules
... Scientists are investigating the potential of using miRNAs in blood or cerebrospinal fluid to diagnose FTD more accurately. Studies have identified several miRNAs that may be useful for distinguishing FTD from AD and other conditions (Deol et al., 2024;Ding et al., 2024). ...
January 2024
International Journal of Biological Macromolecules
... The most employed compound with calcium hydroxyapatite was chitosan [2,12,19,32,35,36], a polymer that stimulates wound healing and improves hemostasis by promoting collagen synthesis by fibroblasts (Figure 4). This substance, with anti-hemorrhagic and antimicrobial properties [54][55][56], increases the stability of the growth factor in grafts. The combination of chitosan and hydroxyapatite appears promising but requires more long-term clinical studies to validate its efficacy and safety [57] (Figure 4). ...
January 2024
International Journal of Biological Macromolecules
... The process of wound repair typically involves four stages, including hemostasis, inflammation, proliferation, and remodeling (Figure 2A). The details are as follows [50][51][52]. (1) Hemostasis phase: In the case of skin injury, the first stage involves blood vessel constriction and fibrin clot formation, which prevent and protect the body from blood loss. (2) Inflammatory phase: After clotting, the body releases white blood cells and other chemicals to clear out infected and dead tissue, facilitating the proliferation of wound tissue. ...
November 2023
Chemical Engineering Journal
... Techniques such as injected hydrogels and 3D printed scaffolds offer tailored treatment solutions, addressing the specific needs of individual patients and serving as crucial therapeutic tools in the bone repair process. [159,[163][164][165][166] Moreover, the integration of responsive materials expands treatment pathways and enables multi-target therapy. By incorporating factors such as growth factors, photothermal, magnetic, and electrical stimulations, these approaches activate biological mechanisms synergistically, ultimately enhancing therapeutic efficacy. ...
October 2023
Molecules
... The findings demonstrated that the interconnected hydrogels showcased enhanced resistance to temperature changes, antioxidative properties, controlled drug release, and ensured safety. Moreover, the combination of paclitaxel and hydrogels expedited the healing process of skin injuries in mice [69]. ...
October 2023
Journal of Materials Science
... Following the recent discovery of the biological activities of plant polysaccharides, their application in animal production has become more prominent. Studies have revealed that adding appropriate doses of plant polysaccharides in animal diets can improve animal performance and meat quality [6], regulate intestinal microbiota structures, and provide favorable conditions for microbial proliferation [7]. Wu et al. [8] showed that feeding Astragalus polysaccharide could improve the growth performance of chickens. ...
September 2023
International Journal of Biological Macromolecules