Xin Mou’s research while affiliated with Red Cross and other places

... Thus, the partial GIPR antagonist, (Pro 3 )GIP, has originally been demonstrated to improve obesity-related diabetes, reducing islet hypertrophy and improving insulin sensitivity [122], while also eliciting 8% weight loss following administration alone in obese mice [123]. These observations have been largely confirmed by others employing GIPR monoclonal antibodies [124]. Interestingly, there is a suggestion that the metabolic benefits of chronic GIPR agonism are related to desensitization of the GIPR, thus mimicking GIPR antagonism [125]. ...

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GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy

... [12][13][14][15] Recent study found that amygdalin ameliorates renal and liver fibrosis mainly by suppressing TGF-β1/Smad signaling pathway and regulating the key enzymes of ECM degradation -Matrix Metalloproteinases-9 (MMP-9) and tissue Inhibitor of Metalloproteinases 1 (TIMP-1). 16,17 In addition, as an active ingredient of Fuzheng Huayu formula, which is a NMPA (National Medical Products Administration)-approved anti-fibrotic medicine in China, amygdalin is effective at alleviating liver fibrogenesis by inhibiting the proliferation and collagen production of active HSC, HSC activation and hepatocyte apoptosis. [18][19][20][21][22][23][24] However, due to the herbal products having multi-modulatory and multi-target action, comprehensive mechanism of anti-fibrotic effects of amygdalin remains elusive. ...

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Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells

... Modern pharmacological studies have found mulberry leaf to have a high median lethal dose (LD50 > 15.0 g·kg⁻ 1 ) and to exhibit safety across various genotoxicity assessments [15][16][17]. Moreover, mulberry leaf aqueous extracts significantly inhibit macrophage inflammatory mediator secretion and autophagic pathways, thereby alleviating obesity [18,19]. In murine models, mulberry leaf demonstrates substantial hypoglycemic effects, modulating blood lipids and gut microbiota [20]. ...

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Explore the mechanism of mulberry leaf combined with gut microbiota to improve hyperlipidemia based on network pharmacology

... Moreover, during dumping of the flowers in landfills would automatically cause them rot and then turn them into a virus (mosaic virus), which is dangerous to humans, animals and the environment. 5 The chrysanthemum plant waste has increased annually during and after festivals or celebrations. If farmers opt to throw them away or burn them up, they cause harmful environmental impacts like air, water and river pollutions. ...

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The influence of fibre orientation and chemical treatment on the performance of unsaturated polyester/chrysanthemum stem fibre composites

... It is estimated that approximately 30-40% of all patients with diabetes develop DN and is the leading cause of end stage renal disease (ESRD) [4]. The ESRD is considered the leading cause of kidney failure and death in patients with DM and that is why it is important to prevent diabetes development into DN [5]. Hyperglycemia, hyperlipidemia, hypertension, advanced glycation products accumulation, duration of diabetes, familial clustering and genetic determinants are some of the risk factors which can make a diabetic patient susceptible to DN [2]. ...

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Significant Association of Candidate Genes (AGTR1 and TGF-Β1) Polymorphism with Diabetic Nephropathy in Diabetes Mellitus Type 2 Patients

... Using microarray analysis, Liu et al. [33] showed that TGF-β1 was one of the differentially expressed genes in early diabetic nephropathy (DN) and non-diabetic samples as its expression was upregulated. Further, serum TGF-β1 has been identified as a risk factor for developing DN and may even serve as a potential biomarker, as shown in a meta-analysis conducted by Mou et al. [34]. However, clinical trials have not demonstrated the effectiveness of anti-TGF-β1 antibodies in preventing DKD progression, suggesting a complex role of TGF-β1 in DKD [35]. ...

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Cellular crosstalk of mesangial cells and tubular epithelial cells in diabetic kidney disease

... It has been shown to have reasonably good psychometric properties 24,25 in various medical settings. [26][27][28][29][30] Versions of 60, 41, and 30 items in Chinese, English, and Japanese 23,31 have been developed and evaluated, 32 with over 2277 papers, 55% of which are journal articles published between 2006 and 2016. 33 Despite its popularity, challenges to its use included 34 (i) difficulty for people with limited education to understand some items, (ii) questionable classification of some items, (iii) many items classified as mixed body constitution, (iv) some items cross-linked to multiple body constitutions, [34][35][36] (v) the originally proposed structure could not be reproduced with empirical data (eg, 8 factors found in research despite the 9 originally proposed in CCMQ), 32,37 and (vi) items not allocated to their intended constitutions (many items in some constitutions, but few items in others). ...

Reference:

Valid and Convenient Questionnaire Assessment of Chinese Body Constitution: Item Characteristics, Reliability, and Construct Validation

... It has been shown to have reasonably good psychometric properties 24,25 in various medical settings. [26][27][28][29][30] Versions of 60, 41, and 30 items in Chinese, English, and Japanese 23,31 have been developed and evaluated, 32 with over 2277 papers, 55% of which are journal articles published between 2006 and 2016. 33 Despite its popularity, challenges to its use included 34 (i) difficulty for people with limited education to understand some items, (ii) questionable classification of some items, (iii) many items classified as mixed body constitution, (iv) some items cross-linked to multiple body constitutions, [34][35][36] (v) the originally proposed structure could not be reproduced with empirical data (eg, 8 factors found in research despite the 9 originally proposed in CCMQ), 32,37 and (vi) items not allocated to their intended constitutions (many items in some constitutions, but few items in others). ...

Reference:

Valid and Convenient Questionnaire Assessment of Chinese Body Constitution: Item Characteristics, Reliability, and Construct Validation