Xiaoying Zheng's research while affiliated with Peking Union Medical College Hospital and other places
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Publications (292)
What is already known about this topic?
Traditionally, life expectancy has served as a pivotal measure for assessing population health. However, there is an increasing focus on distinguishing healthy years of life from those characterized by illness, particularly among the elderly population.
What is added by this report?
This study conducts an ex...
Background
Family environments can shape children’s personalities and social networks, rendering distinguishing adverse childhood experiences (ACEs) from family and society essential, but related evidence remains limited.
Aims
This cross-sectional study aimed to investigate the correlations between intrafamilial and social ACEs, their associations...
Background:
In vitro maturation (IVM) is indicated in women with polycystic ovary syndrome (PCOS) who have a very good ovarian response during in vitro fertilization (IVF) and are therefore at high risk of ovarian hyperstimulation syndrome (OHSS). According to the latest practice committee document, IVM could be a major advance in assisted reprodu...
Introduction
Disparities in life expectancy between rural and urban populations are well established but how it varies with epidemics and pandemics remains poorly understood. We aimed to quantify the rural–urban differences in the mortality burden of COVID-19 and to contribute to understanding the disparity trends in life expectancy between 1987 an...
Background
Adverse childhood experiences (ACEs) and dementia are associated and comorbid with obesity. However, according to emerging research, the role of obesity in the association between ACEs and dementia seems controversial.
Aims
This analysis aimed to explore the associations between ACEs and different dementia subtypes and the effect modifi...
Background:
Adverse childhood experiences (ACEs) are associated with depression in later life.
Objective:
This study aimed to measure the impact of ACEs on life expectancy with depression (DLE) and to assess how educational attainment affected expectations.
Participants and setting:
The study used data on 5597 participants from the English Lon...
Background:
This study aimed to examine urban-rural disparities in the prevalence and trends of depressive symptoms (DS) among Chinese elderly and associated factors.
Methods:
A total of 8025, 7808, and 4887 respondents aged 60 years and above were selected from the China Family Panel Studies (CFPS) in 2016, 2018, and 2020, respectively. DS was...
Objectives:
This study examined the association between number of children and cognitive function and its possible hormone and psychosocial pathways in Chinese menopausal women.
Methods:
We analyzed data from the China Health and Retirement Longitudinal Study (CHALRS), including 4803 menopausal women. Ordinary least squares (OLS) regression mode...
To date, no study has explored the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of atrial fibrillation (AF). This study was designed to investigate the separate and joint effects of long-term exposure to air pollutants and genetic susceptibility on the risk of AF events. This study included 401,251 parti...
The rapid development, approval, and global distribution of COVID-19 vaccines represent an unprecedented intervention in public health history, with over 13 billion doses administered worldwide in two years. However, our understanding of the HLA genetic underpinnings of COVID-19 vaccine-induced antibody responses and their clinical implications for...
What is already known about this topic?:
The elevated prevalence of functional impairment among elderly individuals in China contributes to an increased burden of care.
What is added by this report?:
This report presents a comprehensive evaluation of trends in functional impairment related to activities of daily living (ADL) among the elderly po...
Background:
Aging is a strong risk factor for many chronic diseases. However, the economic burden attributable to age-related diseases remains unclear. We aimed to calculate the economic burden attributable to age-related diseases in China.
Methods:
We used an econometric modelling approach from the China Health and Retirement Longitudinal Surve...
Background:
China's send-down movement in the 1960s and 1970s, as a natural experiment, provides a unique opportunity to investigate the relationship between peers' dissemination of health literacy, community health workers, and infectious disease control in areas with weak health systems and inadequate human resources. To address the lack of stud...
Background:
Life-course disadvantages and unhealthy lifestyles are well-known to independently induce depressive symptoms, but whether adopting healthy lifestyles can dilute the depressive risks attributed to life-course disadvantages remain unknown in China.
Methods:
This population-based cross-sectional study included 5724 middle-aged and olde...
What is already known about this topic?:
Chronic pain has been identified as a risk factor for cardiovascular diseases. Evidence shows that adopting a healthy lifestyle can help reduce the cardiometabolic risks associated with chronic pain.
What is added by this report?:
Results from this cohort study suggest a positive association between chron...
Background
The prevalence and associated factors of suicidal ideation (SI) among the elderly in China varied widely between studies. This meta-analysis firstly aimed to show the epidemiological features of SI among the elderly in China.
Methods
Relevant databases, including English and Chinese, were systematically searched from database inceptions...
Backgrounds: The effect of FGCRS on disability will not be immediate and may have a lag time between the experienced cardiovascular risk and the ultimate health outcome. However, how this effect changes over time is not known. Based on data from China Health and Retirement Longitudinal Study, we aimed to investigate the association between cardiova...
What is already known about this topic?:
The burden of heart disease is increasing rapidly due to the aging population and changing lifestyles in China.
What is added by this report?:
This study investigated the evolution of mortality rates due to heart disease in urban and rural areas of China over the past 35 years, and identified the age-peri...
Objectives:
The SOE reform was the first time that economic insecurity was introduced since 1949 in China, with hundreds of million employees affected by the laid off. This study took the State-Owned Enterprises (SOE) reform in China as a natural experiment to explore the impact of economic insecurity on depressive symptoms in later life.
Methods...
Background: Patterns in urban-rural, gender, and age suicide mortalities in China have shown dramatic changes over the past three decades. This study aimed to explore the long-term patterns of suicide mortality in China from 1987 to 2020.
Methods: Data on suicide mortality were derived from China's National Health Commission. Joinpoint regression a...
Cardiometabolic multimorbidity (CMM) refers to the presence of multiple cardiovascular and metabolic diseases (CMDs), such as hypertension, diabetes, and cardio-cerebrovascular diseases (CCVD), in the same individual, and has emerge as a significant global health concern due to population aging. Although previous research has demonstrated the assoc...
Objectives:
This study aimed to examine the cross-sectional and longitudinal association between multimorbidity and memory-related diseases (MDs) among Chinese middle-aged and older adults.
Methods:
This study included 8,338 subjects who participated in the China Health and Retirement Longitudinal Study (CHARLS). Logistic regression and Cox prop...
Background
China has a high disease burden of respiratory Tuberculosis (TB) and understanding the long-term trends in respiratory TB deaths and their epidemiological characteristics will assist China in achieving the WHO 2035 goal of ending the worldwide TB pandemic. To guide future respiratory TB preventive and intervention initiatives in China, t...
Over the past three years, China has implemented rapid, vigorous, and coordinated control measures to limit the spread of coronavirus disease 2019 (COVID-19) effectively. These measures include active containment, graded management, rational resource allocation, rapid contact tracing and disposal, and targeted vaccination of key populations. These...
Autism spectrum disorder has gained international attention due to its prevalence and the extent to which it can affect families. As a disorder without quantifiable treatment effects, it is easily overlooked in the battle for resources. Estimating family economic burdens and the specific factors that may be associated with them could help in the id...
Background:
According to the latest practice committee document, in vitro maturation (IVM) is a simple and safe procedure, especially in patients with polycystic ovary syndrome (PCOS). Does switching from in vitro fertilization (IVF) to IVM (IVF/M) help as a rescue infertility treatment for PCOS patients with an unexpected poor ovarian response (U...
Population aging is an irreversible process in the development of modern society, which brings challenges to comprehensive modernized social governance. Population aging is a "dualistic" development issue that not only leads to aging of the labor force structure but also creates new demographic dividends. This study describes the core thoughts of d...
Introduction:
The COVID-19 pandemic outbreak have caused increased levels of emotional and behavioral problems, particularly among people with pre-existing mental health conditions. Young individuals with autism spectrum disorders (ASD) and developmental delay (DD) are particularly at risk due to their vulnerability. The purpose of this study was...
Background
Despite accumulating evidence of the long-term impacts of childhood sexual abuse (CSA), few studies have investigated the association between CSA and early sexual debut among adolescents. In this study, we examine the relationship between CSA and early initiation of sexual intercourse among Chinese youth, and the role of school-based sex...
Background:
China has the highest number of new cancer cases and deaths worldwide, posing huge health and economic burdens to society and affected families. This study comprehensively analyzed secular trends of national cancer mortality statistics to inform future prevention and intervention programs in China.
Methods:
The annual estimate of ove...
Objectives
China has implemented an equalization of public health Services policy for migrants in 40 pilot cities since 2013. The main objective of this study is to explore the effect of this migrant-based reform policy on the health status of the migrant population in China.
Methods
Using the China Migrants Dynamic Survey (CMDS), we included 152,...
Background
In the context of climate change, it has been well observed that short-term temperature variability (TV) could increase the overall and cause-specific mortality and morbidity. However, the association between long-term TV and a broader spectrum of diseases is not yet well understood, especially in the elderly.
Methods
Our study used dat...
What is already known about this topic?:
The World Health Organization set a 2030 target of 70% cervical cancer screening coverage for women aged 35-45 years. Coverage stood at 37% in China in 2015.
What is added by this report?:
In 2018-2019, China's cervical cancer screening coverage reached 43.4% in women aged 35-44 years and 36.8% in women a...
BACKGROUND
China has the largest number of new CVDs cases and deaths worldwide, posing huge health and economic burdens to society and families. But the trends in mortality at the national level and urban-rural and gender differences with temporal changes remain unclear.
OBJECTIVE
This study comprehensively analyzed secular trends of national CVDs...
Diabetes mellitus (DM) is a public health challenge in China. Quantifying changes in DM mortality is of great significance, but related evidence of Chinese older adults is scarce. This study conducted a comprehensive analysis of China’s DM mortality changing trajectory. The data from 1987 to 2020 was derived from the National Health Commission of C...
Background
Very limited studies focused on the early-life adversities on infectious diseases. Taking the Great Chinese famine as a natural experiment, this study re-evaluated the long-term effect of prenatal famine exposure on infectious diseases by using nationally representative data.
Methods
Using difference-in-difference (DID) models, we analy...
Objectives
This study aimed to reveal the epidemic characteristics of chronic diseases among the Chinese elderly population and provide empirical strategies for the prevention and management of chronic diseases in the seniors in China.
Design
A national cross-sectional study.
Setting and Participants
A total of 224,640 Chinese residents aged 60 a...
This study aimed to investigate the characteristics of children diagnosed with ASD in China and to estimate ASD treatment patterns in 2020. This study used data from the 2020 Survey on Family Circumstance and Demand Support and Resources among Autistic Children in China. The study sample included 4,557 children diagnosed with ASD aged 2-16 years ol...
Population aging has become a global concern in population development. Challenges to good health in older ages are more complex than at any other age and require a comprehensive framework to move the science of aging and health forward. In this paper, we describe an advanced and evolving conceptual framework that includes definitions, goals, disci...
What is already known about this topic?:
Rehabilitation is an essential part of achieving health for all, whereas the estimates of rehabilitation needs, especially for elderly individuals in China, are not clear.
What is added by this report?:
Compared with 1990, the prevalence and years of life lived with disability for health conditions in nee...
Background: Life-course disadvantages and unhealthy lifestyles are well-known to independently induce depression, but their joint effects on depression and whether adopting healthy lifestyles can dilute the depressive risks attributed to life-course disadvantages remain unknown in China.
Methods: Data were from the China Health and Retirement Longi...
What is already known about this topic?:
Government used mobility restrictions to help contain the first wave of coronavirus disease 2019 (COVID-19) across cities in China. The restrictions were lifted during times of non-zero incidence in response to a return to work order that went into effect on February 10, 2020.
What is added by this report?...
AimsFew studies have focused on the utilization of rehabilitation services among people with schizophrenia. In this study, we aimed to examine the trend of pharmacological and psychotherapy service utilization among adults with schizophrenia and to identify the associated socioeconomic factors.Methods
Data were obtained from the Second National Sam...
What is already known about this topic?:
The global population is predicted to reach 8 billion by the end of 2022, which can delay the progress and exacerbate the challenges of achieving the Sustainable Development Goals (SDGs), especially the goal of "Zero Hunger."
What is added by this report?:
During the next 15 years, it is predicted that th...
Background: Human chorionic gonadotropin (hCG) is synthesized by trophoblast cells and play a critical effect in early pregnancy. The serum hCG concentration is significantly higher in early gestation period achieved through in vitro maturation (IVM) than that by traditional IVF. Since IVM does not involve ovarian hyperstimulation, we wonder whethe...
Background:
Increasing evidence regards the role of ambient particles on morbidity and mortality caused by cardiovascular diseases (CVDs). However, there was no evidence about the association between ambient particles and CVD-associated disability. This study used large national representative data to investigate the relationship between long-term...
Research question
Can inner cell mass (ICM) and trophectoderm morphological grading, especially ICM and trophectoderm graded C, affect perinatal outcomes?
Design
A retrospective review of medical records of 8946 singletons delivered from vitrified–warmed single blastocyst transfer cycles between January 2009 and December 2020.
Results
Inner cell...
Objectives
: This study aimed to investigate the associations between individual-level SES, area-level SES, and their interaction with dementia in China.
Methods
: This study used data from the Second China National Sample Survey on Disability and restricted our finalized analysis to 688507 participants aged 50 years or older. Dementia was ascerta...
Objective
Otitis media is a recognized cause of significant hearing loss, particularly in developing countries. This study aimed to investigate the relationship between otitis media and hearing loss in Chinese adults aged 18 years and older.
Methods
The survey was based on WHO Ear and Hearing Disorders Survey Protocol and 36,783 adults at the ages...
Objective
To explore the clinical outcomes of unstimulated in vitro maturation (IVM) after oocyte retrieval with gynecological surgery (IVM-surgery) for refractory polycystic ovary syndrome (PCOS) and analyze the influencing factors.
Methods
Patients with refractory PCOS who underwent unstimulated IVM-surgery from June 2014 to September 2018 were...
Objectives
To estimate the association between the 2008 Beijing Olympic Games (BOG) and growth of children in China.
Methods
A total sample of 6 951 children aged 3–10 years were included, among which 3 201 were interviewed in 2014 and 3 750 were interviewed in 2018. The BOG was used as a natural experiment. Exposure to the BOG was established by...
Purpose
Diabetes mellitus is emerging as an epidemic worldwide, and the incidence and prevalence of diabetes have drastically changed in China over the past 30 years, but data on its mortality rate are scarce. This study aimed to analyze the time trends of mortality rates among patients with diabetes in the rural and urban population in China betwe...
STUDY QUESTION
Does in vitro maturation (IVM) result in non-inferior cumulative live birth rates compared to those after standard in vitro fertilization (IVF) in infertile women with polycystic ovary syndrome (PCOS)?
SUMMARY ANSWER
One cycle of IVM, without any stimulation, was inferior to one cycle of standard IVF in women with PCOS in terms of 6...
Study question
Is the morphological grading system for blastocysts associated with perinatal outcomes in women undergoing frozen-thawed single blastocyst transfer (SBT)?
Summary answer
Preferential transfer of a blastocyst based on their inner cell mass (ICM) and and trophectoderm (TE) grading appears to be supported by observed differences in per...
Background
The correlation between blastocyst quality and birthweight, neonatal outcomes is still controversial. There is a significantly higher male: female ratio among good quality blastocysts (advanced trophoderm morphology) but in the expansion degree, the significance for sex ratio is unclear.
Methods
A total of 617 and 6803 live singleton bi...
Objective
Hyperlipidemia are common polycystic ovarian syndrome (PCOS)-related metabolic dysfunctions and can adversely affect assisted reproductive technology (ART) outcomes in controlled ovarian hyperstimulation (COH) cycles. The objective of this study is to analyze the relationship between lipid metabolism and ART outcomes in unstimulated natur...
What is already known about this topic? As the largest country in the world, China experienced a demographic transition at a historic scale during the past 50 years with extraordinarily associated changes in the age structure of the population, declining fertility rates, accelerating process of population aging, and growing population scale.
What...
Objective:
To design demand-oriented intelligent analysis platform framework for the disabled population data from overall management to security.
Methods:
DATAI-WebEx, active learning, Browser/Server architecture, role-role-based access control, Bayesian network, GIS analysis technology, cluster analysis, regression analysis and other intellige...
This study compares the effectiveness of COVID-19 control policies on the virus’s spread and on the change of the infection dynamics in China, Germany, Austria, and the USA relying on a regression discontinuity in time and ‘earlyR’ epidemic models. The effectiveness of policies is measured by real-time reproduction number and cases counts. Comparis...
What is already known about this topic?
A previous study found that the size of population with disability was 52.7 million and 84.6 million in 1987 and 2006, with the weighted disability rate of 4.9% and 6.5%, respectively.
What is added by this report?
This study restored the prevalence of disability and its change trajectory in China during 1...
This perspective article provides historical background and current considerations of the regulation of rare diseases and orphan drugs in China, presenting the ongoing reform of the orphan drug assessment system in the context of a maze of seemingly convoluted government agencies and regulatory policies that are unique to the fast developing China.
What is already known about this topic?:
Breast cancer is the most common cancer in women in China and around the world. By 2019, 121 countries have instituted a national screening program as a secondary prevention measure for breast cancer.
What is added by this report?:
Breast cancer screening rates in China were 18.9% in women aged 20 years a...
Background The link between age at marriage and first birth in explaining completed family size is not always direct, due to heterogeneity in circumstances, that compel individual women to marry or initiate childbearing at a particular age. We analyzed data for 1020 women aged 45–49 in 2014 of the 1965–1969 birth cohort from the 2013-14 Zambia Demo...
Background: Disabilities caused by perinatal asphyxia will burden child health and wellbeing. To date, our understanding about the situation and risk factors of perinatal asphyxia-induced disabilities among Chinese children is still limited.
Objectives: To evaluate the prevalence and socio-demographic risk factors of disabilities caused by perinat...
Objectives
Growing evidence has linked outdoor air pollution exposure with higher risk of cognitive impairments. However, the role of indoor air pollution in cognitive decline is not well elaborated. By using nationally representative longitudinal data, this study aimed to explore the effects of indoor air pollution from solid fuel use on cognitive...