Xiaoling Zhang's research while affiliated with Boston University and other places

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Publications (4)

Table 1
Data
  • Sep 2018
Table 2
Data
  • Sep 2018
GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study
Article
Full-text available
  • Jun 2018
Salt sensitivity of blood pressure (BP) increases hypertension risk and associated adverse cardiovascular outcomes. At present, there are no validated rapid tests or diagnostic markers to identify salt sensitivity of BP in clinical practice. Based on our prior animal studies that report a role for brain Gαi2 proteins in the salt sensitivity of BP a...
Abstract 135: PVN Galphai2 Protein Over Expression Attenuates Dahl Salt Sensitive Hypertension and GNAI2 Polymorphic Variance Represents a Clinical Biomarker of the Salt Sensitivity of Blood Pressure
Article
  • Sep 2017
Aim: We hypothesize that a) in the DSS rat, which in contrast to the normotensive DSR rat fails to up regulate PVN Gαi 2 proteins on a high salt intake (Wainford et al, Hypertension 2015), PVN specific Gαi 2 protein over expression will attenuate the development of salt sensitive hypertension (HTN) and, b) SNPs in the GNAI2 gene, which are associat...

Citations

... To examine potential associations between GNAI2 polymorphisms and the salt sensitivity of blood pressure, as suggested by our animal studies, we examined the Genetic Epidemiology of Salt Sensitivity (GenSalt) data set in which the salt sensitivity of blood pressure was rigorously assessed. In an examination of 968 Chinese individuals in GenSalt we found a positive association between the GNAI2 SNP rs10510755 and the salt sensitivity of blood pressure (60). SNP rs10510755 was present in 118 of 369 (~32%) salt sensitive individuals in the GenSalt data set. ...
Reference: Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity
GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study
Citing article
  • Jun 2018