Xiaoling Zhang's research while affiliated with Boston University and other places

Publications (4)

Article
Full-text available
Salt sensitivity of blood pressure (BP) increases hypertension risk and associated adverse cardiovascular outcomes. At present, there are no validated rapid tests or diagnostic markers to identify salt sensitivity of BP in clinical practice. Based on our prior animal studies that report a role for brain Gαi2 proteins in the salt sensitivity of BP a...
Article
Aim: We hypothesize that a) in the DSS rat, which in contrast to the normotensive DSR rat fails to up regulate PVN Gαi 2 proteins on a high salt intake (Wainford et al, Hypertension 2015), PVN specific Gαi 2 protein over expression will attenuate the development of salt sensitive hypertension (HTN) and, b) SNPs in the GNAI2 gene, which are associat...

Citations

... To examine potential associations between GNAI2 polymorphisms and the salt sensitivity of blood pressure, as suggested by our animal studies, we examined the Genetic Epidemiology of Salt Sensitivity (GenSalt) data set in which the salt sensitivity of blood pressure was rigorously assessed. In an examination of 968 Chinese individuals in GenSalt we found a positive association between the GNAI2 SNP rs10510755 and the salt sensitivity of blood pressure (60). SNP rs10510755 was present in 118 of 369 (~32%) salt sensitive individuals in the GenSalt data set. ...