Xiaokai Wang’s research while affiliated with Zhengzhou University and other places

Background It is extremely significant to explore the relationship between ruminative thinking and breathlessness catastrophizing among elderly COPD patients. However, the impact of self‐efficacy on this relationship is still unclear. This study attempted to explore the mediating role of self‐efficacy between ruminative thinking and breathlessness catastrophizing. Design A cross‐sectional study was reported following the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Methods This study was conducted between 10 November 2024 and 25 January 2025, with 225 patients. Data were collected using the valid and reliable instruments, including the Ruminative Response Scale (RRS), the COPD Self‐Efficacy Scale (CSES) and the Breathlessness Catastrophizing Scale (BCS). Additionally, IBM SPSS v28.0 software was used to explore the mediating effect. Results The scores for BCS of most patients were at moderate and high levels. Scores for the RRS and CSES were significantly correlated with the BCS. The analysis of the mediating effect demonstrated that ruminative thinking has a direct predictive effect on breathlessness catastrophizing. Additionally, ruminative thinking can also predict breathlessness catastrophizing indirectly through the mediation of self‐efficacy. The direct effect accounted for 64.4% of the total effect. Conclusion This research revealed that self‐efficacy played a partial mediating role in the relationship between ruminative thinking and breathlessness catastrophizing. Specifically, patients who were trapped in ruminative thinking were more likely to experience heightened breathlessness catastrophizing, but this relationship was mitigated by their level of self‐efficacy. Implications for the Profession and/or Patient Care This finding underscores the significant psychological burden that accompanies the physical symptoms of COPD in this demographic. It is imperative that nurses adopt a holistic approach in the management of elderly COPD patients. Patient or Public Contribution Voluntary patients with elderly COPD hospitalised in the pneumology department were included in the study.

Purpose To determine the influence of inner strength on demoralization in patients receiving chemotherapy for lung cancer and confirm the mediating role of positive coping style. Methods This study was a cross-sectional study and included 210 patients from three general hospitals in China. A sociodemographic questionnaire, Inner Strength Scale, Simplified coping style subscale, and Demoralization Scale-II were applied. A structural equation model was conducted to estimate the hypothesis model of demoralization and explore the potential mediating mechanism. Results Inner strength was positively correlated with positive coping style (P < 0.01). Inner strength, positive coping style, and demoralization were negatively correlated (P < 0.01). Furthermore, positive coping style mediated the relationship between inner strength and demoralization (β = − 0.269 (95% CI, − 0.415, − 0.159), P < 0.01), accounting for 37.41% of the total effect. Conclusion The results suggest a negative association between inner strength and demoralization in patients with lung cancer undergoing chemotherapy. Positive coping style as a mediating variable provided the impetus for the demoralization. Healthcare professionals might enhance the inner strength of lung cancer patients undergoing chemotherapy by carrying out targeted interventions and encouraging them to adopt positive coping strategies, which can reduce the level of demoralization and promote mental health.

Background Children Snoring is a common childhood disorder that affects the growth and development of children and is detrimental to their health. Increasing awareness of Children Snoring among parents is important. Aim To develop the Knowledge-Attitude-Practice of Parents towards Children Snoring Scale and test the reliability and validity of the scale. Methods The development of the tool was divided into two phases involving 1257 parents from China. In the first phase, an initial project bank was created through a literature review. This was followed by a Delphi expert consultation, group discussion and pre-survey. The second stage screened the items and conducted an exploratory factor analysis, then conducted a confirmatory factor analysis and tested for reliability and validity. Results Support was found for the 25-item Knowledge-Attitude-Practice toward Children Snoring scale. Exploratory and confirmatory factor analyses provide support for four subscales: (parental basic cognition toward Children Snoring; parents’ perception of complications of Children Snoring; parents’ attitude towards Children Snoring; parents’ concern and prevention of Children Snoring). Internal consistency for the total scale was high (Cronbach’s α = 0.93). The intraclass correlation coefficient of test-retest reliability was 0.92 (95%CI: 0.85 to 0.95), which provided support for the stability of the scale. Conclusion The Knowledge-Attitude-Practice of Parents towards Children Snoring scale shows promise as a measure that may be used by medical workers and community children’s health managers.

Background Lung cancer is the malignant tumor with the highest morbidity and mortality rate in China. Although chemotherapy is effective in improving clinical symptoms, it causes a variety of acute and chronic side effects, seriously aggravating the psychological stress of patients. Laughter Yoga as a new type of aerobic exercise can effectively reduce stress levels and increase positive mood in patients. This study aimed to examine the effects of laughter yoga on perceived stress, positive psychological capital, and exercise capacity in lung cancer patients. Methods This study was a randomized, single-blind, parallel-group trial. The study enrolled 84 lung cancer chemotherapy patients from a general hospital in central China. These patients were randomly allocated to control and intervention groups (n = 42 per group) after baseline assessments. Patients in the control group received routine care and those in the intervention group received laughter yoga intervention. Perceived stress, positive psychological capital, and exercise capacity were assessed at baseline, immediately post-intervention. Results During the implementation of the study, there were 2 dropouts in each of the intervention and control groups. Ultimately, 80 patients in the control and intervention groups completed the trial. Patients who received laughter yoga intervention had significantly higher scores in positive psychological capital (P < .01, Cohen’s d = 0.692) and exercise capacity (P < .01, Cohen’s d = 0.659). Discernible differences were also observed in perceived stress (P < .01, Cohen’s d = 1.087) between the 2 groups. Conclusions The results of this study suggest that laughter yoga is an effective way and may produce beneficial effects on perceived stress, positive psychological capital and exercise capacity.

This study aimed to investigate the antitumor effect and the underlying molecular mechanism of eriodictyol on ovarian cancer cells. CaoV3 and A2780 were exposed to eriodictyol at different concentrations of 0-800 μM. Cell apoptosis and viability were determined by TdT-mediated dUTP Nick-End Labeling (TUNEL) assay and Cell Counting Kit-8 (CCK-8) assay, respectively. Mitochondrial membrane potential was evaluated by flow cytometers with a JC-1 detection kit. Fe2+ content was evaluated using an iron assay kit. The section of tumor tissues was observed using hematoxylin-eosin (H&E) staining and nuclear factor erythroid 2-related factor 2 (Nrf2) expression was detected by immunohistochemistry (IHC) staining. Eriodictyol suppressed cell viability and induced cell apoptosis of CaoV3 and A2780 cells. Half maximal inhibitory concentration (IC50 ) value of CaoV3 at 24 and 48 h was (229.74 ± 5.13) μM and (38.44 ± 4.68) μM, and IC50 value of A2780 at 24 and 48 h was (248.32 ± 2.54) μM and (64.28 ± 3.19) μM. Fe2+ content and reactive oxygen species production were increased and protein levels of SLC7A11 and GPX4 were decreased by eriodictyol. Besides, eriodictyol reduced the ratio of JC-1 fluorescence ratio, glutathione and malondialdehyde contents but elevated Cytochrome C level. Nrf2 phosphorylation were obviously downregulated by eriodictyol. Finally, eriodictyol suppressed tumor growth, aggravated mitochondrial dysfunction and downregulated Nrf2 expression in tumor tissue in mice. Eriodictyol regulated ferroptosis, mitochondrial dysfunction and cell viability via Nrf2/HO-1/NQO1 signaling pathway in ovarian cancer.

Background: Children Snoring is a common childhood disorder that affects the growth and development of children and is detrimental to their health. However, awareness of the disease among parents in the community is at a low level. Aim: To develop the Knowledge-Attitude-Practice of Parents towards Children Snoring Scale and test the reliability and validity of the scale. Methods: The development of the tool has been divided into two phases involving 1257 parents from China. In the first phase, an initial project bank was created through a literature review. This was followed by a Delphi expert consultation, group discussion and pre-survey. The second stage screened the items and conducted an exploratory factor analysis, then conducted a confirmatory factor analysis and tested for reliability and validity. Results: The scale has a good content validity index. It consists of four factors and 63.3% of the total variance is explained by 25 items. The confirmatory factor analysis also validates the 4-factor structure with a good overall reliability 0.93 and a test-retest reliability of 0.83. The scale is a good tool to measure the state of children’s parents about the Knowledge-Attitude-Practice toward Children Snoring. Conclusion: The Knowledge-Attitude-Practice of Parents towards Children Snoring scale is a valid and reliable instrument.

Objectives The lung cancer is most frequently diagnosed cancer incidence worldwide. A large number of populations are heavily affected to this every year with poor prognosis. Methods Our study investigated the anticancer effect of alternariol, a secondary metabolite, on A549 lung cancer cell line and benzo-α-pyrene induced lung carcinoma model on balb/c mice. The cytotoxicity assay, DAPI staining and the flow cytometry was performed to assess the anticancer efficacy of alternariol in A549 lung cancer cell. For in vivo study the toxicity study was performed. The lung cancer was developed in the animals via intraperitoneal administration of benzo-α-pyrene and subsequently 2 weeks later alternariol treatment was carried out for 24 weeks. The chemotherapeutic effect of alternariol was assessed through histopathological analysis, followed by immunohistochemistry and in vivo antioxidant study. Results The in vitro data suggested a significant percentage of early and late apoptotic events in A549 cells with G0/G1 phase arrest which ultimately caused apoptosis followed by alternariol therapy. The in vivo study showed that alternariol therapy decreased the pulmonary fibrosis and formation of granuloma in lung tissue and restored the normal histopathological characteristics of lung. Furthermore, alternariol treatment downregulated the expression of PI3K, Akt and inflammatory mediators such as IL-6, TNF-α and increased the expression of apoptotic markers, p53. Conclusion In conclusion, the treatment with alternariol effectively decreased the progression of lung cancer through the inhibition of carcinogenic markers by reprogramming the p53/PI3K/Akt pathway and IL-6/TNF-α mediated cytokine signaling in mice.