Xiaochen Zhang’s research while affiliated with Shanghai Jiao Tong University and other places

What is this page?

This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.

Publications (1)

TMS-related changes in clinical assessments. (a) The 24-item HDRS total scores significantly decreased after TMS treatment (p <0.0001). (b) The MADRS total scores significantly decreased following TMS treatment (p <0.0001). HDRS, Hamilton Depression Rating Scale; MADRS, Montgomery–Åsberg Depression Rating Scale; TMS, transcranial magnetic stimulation.
TMS-related changes in clinical assessments. (a) The 24-item HDRS total scores significantly decreased after TMS treatment (p <0.0001). (b) The MADRS total scores significantly decreased following TMS treatment (p <0.0001). HDRS, Hamilton Depression Rating Scale; MADRS, Montgomery–Åsberg Depression Rating Scale; TMS, transcranial magnetic stimulation.
Voxel-wise TBSS analysis of correlations between WM metrics and the reduction of MADRS scores. Significant clusters (red to yellow) are shown on the WM skeleton (green). The color bars represent the FA value. Clusters were identified, wherein NDI (a) and FWF (b) exhibited significant positive correlations with the reduction of MADRS scores. CC, corpus callosum; FA, fractional anisotropy; FWF, free-water fraction; IC, internal capsule; MADRS, Montgomery–Åsberg Depression Rating Scale; NDI, neurite density index; PCR, posterior corona radiate; PTR, posterior thalamic radiation; SCR, superior corona radiate; TBSS, tract-based spatial statistics; WM, white matter.
Voxel-wise TBSS analysis of correlations between WM metrics and the reduction of MADRS scores. Significant clusters (red to yellow) are shown on the WM skeleton (green). The color bars represent the FA value. Clusters were identified, wherein NDI (a) and FWF (b) exhibited significant positive correlations with the reduction of MADRS scores. CC, corpus callosum; FA, fractional anisotropy; FWF, free-water fraction; IC, internal capsule; MADRS, Montgomery–Åsberg Depression Rating Scale; NDI, neurite density index; PCR, posterior corona radiate; PTR, posterior thalamic radiation; SCR, superior corona radiate; TBSS, tract-based spatial statistics; WM, white matter.
The WM metric was an independent predictor of antidepressant response to TMS treatment. The WM metrics, NDI (a) and FWF (b), within corresponding clusters were significant independent predictors of antidepressant response to TMS in multivariate analyses of baseline clinical variables. The combination of WM metrics within identified clusters could predict the change in MADRS scores (NDI [c]: p=0.0009, R² = 0.33; FWF [d]: p=0.0006, R² = 0.34).  ∗ indicates p<0.05. FWF, free-water fraction; MADRS, Montgomery–Åsberg Depression Rating Scale; NDI, neurite density index; TMS, transcranial magnetic stimulation; WM, white matter.

+5

Intra- and Extracellular White Matter Micromorphology Predict the Antidepressant Effects of Transcranial Magnetic Stimulation in Patients With Major Depressive Disorder
  • Article
  • Full-text available

February 2025

·

30 Reads

Sirui Wang

·

Xiaochen Zhang

·

·

[...]

·

Background: Transcranial magnetic stimulation (TMS) is a widely used treatment for major depressive disorders (MDD). However, its physiological effects remain unclear, and its efficacy varies among patients. Functional connectivity (FC) within MDD-related networks has shown potential for predicting TMS efficacy. White matter (WM) micromorphology contributes to these connections and may provide new insights into the prediction of TMS effects and its antidepressant mechanism in MDD, which has not been thoroughly investigated. Therefore, this study aimed to identify potential predictors of TMS efficacy using whole-brain WM microstructural characteristics. Methods: This retrospective study included 41 patients with MDD who completed 20-session TMS treatments. We examined intra- and extracellular WM using neurite orientation dispersion and density imaging (NODDI). We examined the correlations between pre-TMS whole-brain WM measures and the reduction in Montgomery–Åsberg Depression Rating Scale (MADRS) scores after TMS, as well as the longitudinal changes in regional WM measures correlated with MADRS reduction. Results: The pre-TMS intracellular neurite density index (NDI) within the bilateral internal capsule (IC), right posterior corona radiata (PCR), right superior corona radiata (SCR), corpus callosum (CC), and bilateral posterior thalamic radiation (PTR) were positively associated with the reduction in MADRS scores. The pre-TMS extracellular free-water fraction (FWF) within the bilateral IC, splenium of the CC, and right SCR was significantly related to the reduction in MADRS scores. The FWF within the left posterior limb of the IC, left PCR, and left SCR decreased after TMS treatment. Limitations: The study’s findings cannot rule out the potential effects of concurrent pharmaceutical therapies, as a control group not receiving TMS treatment was not included. Conclusions: Regional NDI and FWF values at baseline could predict TMS efficacy in patients with MDD. Reducing the extracellular FWF in the left hemisphere may be a potential therapeutic mechanism of TMS in MDD.

Download