Xiaochen Zhang's research while affiliated with The Ohio State University and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (54)
Background:
Breast cancer survivors (BCS) with overweight or obesity are at heightened risk of cancer recurrence, cardiometabolic disease, and compromised quality of life. Given the prevalence of significant weight gain during and following breast cancer treatment, there is growing recognition of the need to develop efficacious, widely-accessible,...
Background
Weight loss through lifestyle modification can produce health benefits and may reduce cancer risk. The goal of this study was to examine the feasibility of and adherence to a 15-week telephone-based weight loss intervention in rural Ohio, an area with high rates of obesity.
Methods
This pilot 2-arm randomized controlled study was design...
Background:
During the COVID-19 pandemic, enforced social distancing initiatives have highlighted differences in social distancing practices and the resulting loneliness in various populations. The objective of this study was to examine how cancer history and social distancing practices relate to loneliness during COVID-19.
Methods and findings:...
Purpose:
To examine delays in cancer screenings during the COVID-19 pandemic.
Methods:
Participants from previous studies (N = 32,989) with permissions to be recontacted were invited to complete a survey between June and November 2020. Participants (n = 7,115) who met the age range for cancer screenings were included. Participants were asked if...
Background: COVID-19 has negative impacts on mental health in all populations. Individuals with a history of cancer have an increased risk of catching and having more severe symptoms of COVID-19 than the general public. The objective of this study was to examine how cancer history and concern for catching COVID-19 relate to anxiety.
Methods: This...
Introduction
There is limited data comparing patient and physician expectations regarding ovarian cancer prognosis. Our primary objective was to compare physician and patient estimates of survival to 6 months, 1 year, and 5 years; secondary objectives included comparing provider and patient responses on the likelihood of requiring future treatments...
Despite efforts of professional organizations and government agencies to solidify the professional identities of community health workers and patient navigators in the oncology workforce, the scientific literature perpetuates wide variation in the nomenclature used to define these natural change agents, who have proven efficacy in improving access...
10547
Background: Disruptions of daily life activities during the CVOID-19 pandemic have adversely affected cancer-prevention behaviors. Socioeconomic status (SES) impacts on changes in cancer prevention behaviors have not been fully investigated. To tackle this gap, we examined the effects of SES on COVID-19 related changes in cancer prevention be...
e24124
Background: Due to COVID-19, social distancing initiatives have been enacted, highlighting differences of social distancing practices and the resulting loneliness in various populations, especially in those with a history of cancer (survivors and those in active treatment). The objective of this study was to examine whether social distancing...
Importance:
Lower extremity lymphedema (LEL) is associated with decreased physical functioning (PF) and activities of daily living (ADLs) limitations. However, the prevalence of LEL in older survivors of cancer is unknown.
Objectives:
To examine LEL among older female survivors of colorectal, endometrial, or ovarian cancer and investigate the as...
Being overweight or obese is a primary modifiable risk factor that exacerbates disease progression and mobility disability in older knee osteoarthritis (OA) patients. Lifestyle interventions combining exercise with dietary weight loss (EX+DWL) yield meaningful improvements in mobility and weight loss that are superior to EX or DWL alone. Unfortunat...
Objective
The oral-cervical human papillomavirus (HPV) infection/cancer relationship is not well established. Oral-cervical HPV studies were reviewed to assess dual-site occurrence, HPV type concordance, and study quality/deficiencies.
Methods
PubMed, EMBASE, Ovid Medline, and Web of Science were searched between 1/1/1990 and 8/10/2021 for studies...
Objectives: To determine whether self-efficacy and social support mediate the association between intervention attendance and changes in health behaviors; and to quantify the dose-response relationship between changes in health behaviors and weight loss outcomes. Methods: Data were from a group-randomized trial that compared a 1-year faith-based we...
We examined the factors associated with physical activity following cancer treatment among older breast cancer survivors from the WHI LILAC study. The majority of participants (n=3,710, mean age=78.8±5.9) were white (86%), and had in situ/localized breast cancer (79%). Women who received radiation therapy, were underweight/normal weight, had fewer...
Introduction
Physical activity can attenuate cancer-related declines in physical functioning, improve emotional well-being, and prolong survival among older (≥65 years) breast cancer survivors. However, factors associated with physical activity among older breast cancer survivors are not well-understood.
Materials and methods
Participants were enr...
e24035
Background: Post-treatment weight gain places breast cancer (BCa) survivors at heightened risk for cardiovascular disease, metabolic syndrome, and functional decline. Lifestyle weight management (LWM) interventions combining exercise and dietary weight loss represents an effective approach to mitigating the adverse cardiometabolic and functi...
Objectives:
To determine the association of physical activity and body image with psychological health outcomes and whether body image mediates the association of physical activity with psychological health among older female cancer survivors.
Materials and methods:
Data from the Women's Health Initiative (WHI) Life and Longevity after Cancer (L...
Background:
Cancer survivors have a higher risk of developing and dying from cardiovascular disease (CVD) compared to the general population. We sought to determine whether 10-year risk of atherosclerotic CVD (ASCVD) is elevated among those with vs. without a cancer history in a nationally representative U.S. sample.
Methods:
Participants aged 4...
Purpose of Review
Breast cancer–related lymphedema (BCRL) is a common sequelae among breast cancer survivors. This review provides updated information on recent studies to prevent, diagnose, and actively treat women with BCRL.
Recent Findings
In total, 63 articles were identified from 2015 and 2020 that assessed incidence, risk factors, surveillan...
Purpose:
We sought to determine whether the association between physical activity and 10-year cardiovascular disease (CVD) risk varies among normal weight, overweight, and obese adults in a nationally-representative sample of the United States.
Methods:
Data were from the National Health and Nutrition Examination Survey 2007-2016. A subset of 22...
Purpose
Weight cycling, defined as intentional weight loss followed by unintentional weight regain, may attenuate the benefit of intentional weight loss on endometrial cancer risk. We summarized the literature on intentional weight loss, weight cycling after intentional weight loss, bariatric surgery, and endometrial cancer risk.
Methods
A systema...
Introduction
The National Comprehensive Cancer Network (NCCN) guidelines recommend intraperitoneal chemotherapy in optimally debulked stage III ovarian cancer patients. The objective of this investigation was to determine the rate of intraperitoneal port placement in patients undergoing surgery for ovarian cancer in a national database maintained b...
Published studies regarding patient navigation (PN) and cancer were reviewed to assess quality, determine gaps, and identify avenues for future research. The PubMed and EMBASE databases were searched for studies investigating the efficacy and cost‐effectiveness of PN across the cancer continuum. Each included article was scored independently by 2 s...
Objective:
The goal of this study was to develop and assess intra and inter-rater reliability and validity of a clinical evaluation tool for breast cancer related lymphedema, for use in the context of outcome evaluation in clinical trials DESIGN: Blinded repeated measures observational study.
Setting:
Outpatient research laboratory.
Participant...
Purpose/objectives:
Current guidelines do not recommend routine surveillance imaging as part of follow-up care for patients treated for locoregional endometrial carcinoma. This study seeks to determine the potential benefit of routine surveillance imaging by evaluating outcomes of patients whose recurrences were detected on routine surveillance co...
Purpose:
Clinical guidelines recommend that breast cancer (BrCa) survivors be prescribed exercise. However, clinicians often do not prescribe exercise citing the presence of multiple health issues found among cancer survivors. No study has examined the proportion of BrCa survivors that can be prescribed a community/home-based unsupervised exercise...
PurposePatients with human papillomavirus (HPV)-related head and neck cancer (HNC) have a better prognosis relative to other types of HNC, making survivorship an emerging and critical issue. Exercise is a core component of survivorship care, but little is known about how many survivors of HPV-related HNC can safely be advised to start exercising on...
Objective:
To compare 30-day postsurgical readmission rates and associated risk factors for readmission among women undergoing gynecologic surgery for benign and malignant conditions.
Methods:
In a retrospective cohort study, we identified patients after surgery for benign and malignant gynecologic conditions in the National Surgical Quality Imp...
Background:
Studies in breast cancer-related lymphedema (BRCL) have exclusively examined total arm volume, but not the specific tissue composition that contributes to total volume. We evaluated baseline differences in arm tissue composition [fat mass, lean mass, bone mineral content (BMC), and bone mineral density (BMD)] between the affected and u...
Purpose/objectives:
To establish the feasibility and acceptability of completing a higher dose of the planned physical activity volume among women with ovarian cancer, including those undergoing active treatment.
.
Design:
A pre-/post-test exercise intervention. All participants were asked to complete 225 minutes per week of physical activity...
The combination of an increasing number of new cancer cases and improving survival rates has led to a large and rapidly growing population with unique health-care requirements. Exercise has been proposed as a strategy to help address the issues faced by cancer patients. Supported by a growing body of research, major health organizations commonly id...
114
Background: We evaluated baseline differences in arm tissue composition (fat mass, lean mass, bone mineral content [BMC] and bone mineral density [BMD]) between the affected and unaffected arms in women with breast cancer-related lymphedema (BRCL). We compared changes in arm tissue composition and self-reported lymphedema symptoms after one-yea...
Background:
Women with gynecologic cancer are at higher risk of venous thromboembolism (VTE) due to malignancy, pelvic surgery, increased age, and frequently comorbidities. The rate of VTE among different gynecologic cancers and relative to benign gynecologic surgeries has not been reported in a nationally representative cohort.
Methods:
Using t...
Approximately 50% of high-grade serous ovarian cancers (HGSOCs) have defects in genes involved in homologous recombination (HR) (i.e., BRCA1/2). Preclinical models to optimize therapeutic strategies for HR-deficient (HRD) HGSOC are lacking. We developed a preclinical platform for HRD HGSOCs that includes primary tumor cultures, patient-derived xeno...
De-identified Data for Sharing (As Requested).
(DTA)
Objectives:
We sought to quantify the relationship between body mass index (BMI) and physical function among endometrial cancer survivors. Understanding this relationship would help healthcare providers target efforts to refer obese endometrial cancer survivors to weight loss and exercise interventions.
Methods:
We conducted a survey of 213 endo...
Comparison of Characteristics between Endometrial Cancer Survivors Who Completed Survey and Who Didn’t Complete Survey.
(DOCX)
Purpose:
Racial disparities in uterine cancer-related outcomes have been reported. The goal of this study was to determine if race, pre-operative body mass index (BMI), and medical comorbidities are predictors of loss of functional independence after hysterectomy for uterine cancer.
Methods:
Loss of independence was defined as a change from pre-...
Introduction:
To compare 30 day postoperative readmission rates and risk factors for readmission between women following benign and malignant gynecologic surgery.
Methods:
We identified patients following benign and malignant gynecologic surgery in the National Surgical Quality Improvement Program database from 2006-2012. Data collected included...
To determine the proportion of endometrial cancer patients who can be safely prescribed community/home based unsupervised exercise. A better understanding of the physical dysfunction secondary to comorbidities among endometrial cancer patients would assist clinicians in delineating which patients to send to medically-based supervised rehabilitation...
Introduction
Racial disparities in uterine cancer-related outcomes have been reported. Black uterine cancer patients are more likely to have worse clinical outcomes, which are not fully explained by number of comorbidities. Few studies have investigated the factors that may influence functional independence following surgery for uterine cancer. The...
Citations
... The survey elements were finalized in conjunction with other members of the IC-4 [17,18]. The survey included individual behaviors related to the mitigation of COVID-19 transmission, the challenges related to social distancing, and self/family isolation, stress, and health behaviors that are highly relevant to cancer and other chronic diseases. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281105497131-1670419790817_Q64/Mohamed-Elsaid-26.jpg)
... Online YouTube videos were available to participants demonstrating safe and effective techniques for each of the prescribed exercises, providing examples for alternative exercise options, and providing tips for proper exercise form. These videos have been successfully implemented to facilitate home-based exercise in prior lifestyle interventions [39]. In order to maintain a safe and gradual progression in exercise stimulus, each week, participants were encouraged to increase their exercise frequency, duration, and/or intensity until successfully attaining the target physical activity volume goal. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272784681074704-1442048344367_Q64/Kevin-Hackshaw.jpg)
... Lower-body strength was assessed using the 30-s chair stand (G2 only, online) [3,6]. The number of repetitions performed in 30 s was recorded, with higher scores indicating superior lower-body strength. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/277180694188037-1443096435901_Q64/Jessica-Krok-Schoen.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/396830455156736-1471623161049_Q64/Michael-Pennell-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1148750630273025-1650894901444_Q64/Nazmus-Saquib-3.jpg)
... Clinicians could look to existing literature in patients with other cancers for strategies to overcome such barriers and utilise such enablers. Behavioural support interventions such as personalised exercise programs, tracking devices, exercise reminder messages and phone calls, and group interaction (DeScenza et al., 2021;Haynam et al., 2021;Chan et al., 2020), could be investigated for PF therapy in gynaecology-oncology. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1030686542659584-1622746229497_Q64/Ciaran-Fairman-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1162233899945984-1654109563869_Q64/Jessica-Bowman-8.jpg)
... Clinicians could look to existing literature in patients with other cancers for strategies to overcome such barriers and utilise such enablers. Behavioural support interventions such as personalised exercise programs, tracking devices, exercise reminder messages and phone calls, and group interaction (DeScenza et al., 2021;Haynam et al., 2021;Chan et al., 2020), could be investigated for PF therapy in gynaecology-oncology. ...
... As participantes mais velhas demonstraram certo grau de autocensura ou renúncia em se preocuparem com a própria imagem. Pesquisas têm apontado, no entanto, que preocupações relacionados à imagem corporal ainda estão presentes neste grupo etário, porém as mulheres mais velhas raramente formam a população-alvo de estudos que avaliam a imagem corporal, provavelmente baseado numa suposição etarista de que a aparência não é uma preocupação para elas, quando comparadas a seus pares mais jovens, que o adoecimento de mulheres mais jovens é mais chocante e trágico, e ainda que a necessidades das pacientes mais jovens têm maior apelo social do que a das mais velhas (Campbell-Enns & Woodgate, 2015;Davis et al., 2020;Zhang et al., 2021). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/370315449389056-1465301491283_Q64/Brittany-Bernardo.jpg)
... Additionally, a recent crosssectional study of 15,096 adults found cancer survivors had 3.42 (95% confidence interval (CI): 2.51-4.66) times the odds of being categorized as high ASCVD risk by the PCEs but did not investigate the longitudinal association of the PCEs with ASCVD incidence or the performance of the PCEs in this population [19]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272797381427242-1442051372753_Q64/Karen-Williams-29.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/273549672882177-1442230732149_Q64/Ashley-Felix.jpg)
... Breast Cancer-Related Lymphedema (BCRL) is a physical and socio-psychological problem in breast cancer patients, signi cantly reducing ADL and quality of life [1,2,3,4,5,6,7]. Breast cancer is a frequent cancer with more than 2.08 million new cases worldwide in 2018 [8], but breast cancer survival rates continue to improve [9,10]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/987152884178944-1612366996054_Q64/Jill-Oliveri.jpg)
... Physical function and frailty have emerged in recent clinical and epidemiological investigations as intervention targets to improve in hematological cancer survivorship [30][31][32]. To date, controlled exercise trials in cancer populations have primarily targeted survivors of solid malignancies such as breast [33][34][35], prostate [36][37][38], colorectal [39][40][41], and lung [42][43][44] cancer. There is a paucity of information on optimal rehabilitation strategies to improve physical function and frailty in patients with multiple myeloma at risk of developing frailty. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/773746256269313-1561486891463_Q64/Zachary-Chaplow.jpg)
... (20,22,24) Epidemiologic studies noted specific relationships between physical activity and health outcomes that include increased cardiorespiratory and muscle fitness (27) as well as decreased risk of all-cause mortality and cardiovascular disease. (28) Physical training is an effective strategy for improving quality of life and emotional health status (29) and can diminish morbidities associated with obesity, such as depression and anxiety. (15) Studies have shown that physically active individuals have higher scores for certain subdimensions of QoL domains compared to physically inactive individuals. ...
