Xiao-Ming Zhao’s research while affiliated with Tongji University and other places

... More intriguingly, despite the wide array of studies of the click chemistry of unconjugated alkynes, very little work on the click chemistry of 1,3-diyne has been reported. Zhao et al. reported a cycloaddition of 1,3diynes with sodium azide to synthesize alkynyl-1,2,3-triazoles. 4 While this reaction with sodium azide has no consequence on regioselectivity, the use of an organic azide brings regioselectivity into play. The regioselectivity of the click reaction of a terminal alkyne can be controlled by using metal catalysts, 5−8 but the regioselectivity of internal alkynes is generally dependent on the nature of the substituents irrespective of the catalyst. ...

Reference:

Double Regioselective Thermal Azide–Alkyne Cycloaddition of 1,3-Diynes

... However, the Wilcoxon test evaluated between the PCa serum and tissue shows that miRNA 183 expression was highly significant and upregulated in tissue by 3.89-fold as compared to the serum. However, the dysregulation of miRNA is reported to be responsible for carcinogenesis in various cancers like ovarian, esophageal squamous cell, bladder, colorectal, breast, brain glioma, colon, and prostate, with upregulated expression, while other melanoma, kidney, cervical, osteosarcoma, and gastric cancers have downregulated expression [11,12]. Despite being reported as a biomarker in PCa, there are very few studies that indicate its circulating non-invasive biomarker potential in PCa biofluids. ...

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Discovery and Validation of Novel microRNA Panel for Non-Invasive Prediction of Prostate Cancer

... The process of ovarian stimulation has an impact on the microRNA profile of the endometrium, which in turn affects the receptivity of the endometrium [148]. Previous studies showed that when women undergo ovarian stimulation, it causes their estrogen [149] and P4 amounts to become higher than normal during the late follicular stage [150] . ...

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MicroRNAs, endometrial receptivity and molecular pathways

... 17,18 Similar sulfonic acids g with central chirality were obtained by Zhao using asymmetric iridium-catalyzed allylation with sodium sulfite. 19 The development of chiral sulfonic acids is not limited only to central chirality. The synthesis of optically pure BINOL-derived disulfonic acids h (BINSA) was reported by Ishihara. ...

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Axially Chiral Sulfonic Acids for Brønsted Acid Catalysis: 8-Benzoimidazolylnaphthalene-1-sulfonic Acids and Their Derivatives

... Treatment with COS has been shown to induce host defense responses and delay fruit senescence (Yang et al. 2010). A low concentration of COS was shown to promote the germination of cucumber seeds, and to increase certain growth indexes (leaf area, root length) and physiological indexes (chlorophyll content and net photosynthetic rate of functional leaves) in cucumber seedlings (Ma et al. 2011). Treatment with COS at 15 g kg −1 effectively delayed the degradation of cellulose and lignin in mandarin fruit . ...

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Effect of split application of nitrogen combined with chitooligosaccharide on lodging in rice

... 108 They further developed this methodology by demonstrating the enantioselective formation of analogous allyl carbamates from allyl carbonates and amines, using the released CO 2 in the presence of the same Ir complex under mild reaction conditions (Scheme 38b). 109 Later on Subsequent depolymerization of these polycarbonates using various primary or secondary amine nucleophiles afforded optically active carbamates, with the complete configuration retention of the two chiral carbon centers (Scheme 39). ...

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CO2 and asymmetry: Reviewing the advances in enantioselective catalytic strategies

... GnRHa long protocol has longer and deeper pituitary downregulation compared to GnRHa short protocol. Longer pituitary downregulation significantly increased the number of mature oocytes [27], implantation rate, the number of good-quality embryos [28], clinical pregnancy rate, and live birth rate [29]. Recent studies support that longer pituitary downregulation favors ART outcomes regardless of age or ovarian response. ...

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MTHFR 677TT is associated with decreased number of embryos and cumulative live birth rate in patients undergoing GnRHa short protocol: a retrospective study

... Additionally, these outcomes closely matched those of Ruiz et al. (2013), who observed values of 56.5% and 63.5%, respectively, after vitrifying mature alpaca oocytes for 45 and 30 seconds using 30% EG. However, Wang et al. (2014) found that combining 30% EG with 20% FBS for 45 seconds had better outcomes 93.6%. While in camelids, EG has been effectively applied to the vitrification of alpaca oocytes and embryos (Ruiz et al., 2013 andVivanco-Mackie, 2013), llama (Aller et al., 2002), and dromedary (Nowshari, 2005). ...

Reference:

Impact of Various Serum Concentrations and Cryoprotectants on The in vitro Maturation of Vitrified Dromedary Camel Oocytes

... Catalysts 2022, 12 Due to the importance of these moieties, different strategies for obtaining them have been developed in the past (Scheme 1). Zhao and coworkers published the transition metal catalyzed allylic substitution with sodium benzotriazolide [13,14]. Despite the excellent enantioselectivities in some cases, the method lacks regioselectivity and requires deprotonation of the triazole in a previous step. ...

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Rhodium-Catalyzed Dynamic Kinetic Resolution of Racemic Internal Allenes towards Chiral Allylated Triazoles and Tetrazoles

... To overcome this challenge, alkyl-and aryl sodium thiolates have been applied in the Ir-catalyzed reaction of linear allylic carbonates to give the corresponding allylic sulfides in good yields and selectivities. [33][34][35] The use of branched, aryl-substituted allylic alcohols in the presence of dibutyl phosphoric acid has been recently reported in the Ir-catalyzed asymmetric thioetherification. [36] Reaction of aliphatic and electron-deficient allylic alcohols by this method, [36] however, underwent kinetic resolution. ...

Reference:

Iridium‐Catalyzed Enantioselective Allylic Substitutions of Racemic, Branched Trichloroacetimidates with Heteroatom Nucleophiles: Formation of Allylic C−O, C−N, and C−S Bonds