Wong Tin Wui's research while affiliated with Universiti Teknologi MARA and other places

Publications (21)

Article
Breast cancer is the most common malignancy in women and is rated among one of the three common malignancies worldwide in combination with colon and lung cancer. The escalating mortality rate of breast cancer patients has captivated the attention of the present-day researchers to come up with new management options. According to WHO, early detectio...
Article
Full-text available
Transdermal drug delivery system provides continuous controlled delivery of active ingredients through the human skin and into the bloodstream. Poor penetration of most drugs into the skin has led to numerous studies being conducted to increase their permeability. The present study investigated the ability of Hibiscus rosa-sinensis L. (HRS) leaves...
Article
Background Solid dispersion (SD) is an established approach to increase the solubility and dissolution of BCS class II drugs. The selection of a suitable method of preparation and the suitable polymeric carrier are the two most important parameters for a successful SD. The present research is aimed to evaluate the effect of preparation method on dr...
Article
Chitosan has not been able to be formulated as sustained-release crosslinked/coacervated drug carrier in the form of spheroids prepared by extrusion-spheronisation technique. This study re-visits chitosan spheroids and their drug (water-soluble chlorpheniramine maleate) release profiles as a function of crosslinking reaction and coacervation betwee...
Article
In this research, the palm oil ester (POE)- based nanoemulsion formulation containing quercetin for pulmonary delivery was developed. The nanoemulsion formulation was prepared by high energy emulsification method and then further optimized using D-optimal mixture design. The concentration effects of the mixture of POE:ricinoleic acid (RC), ratio 1:...
Article
Full-text available
Palm-based nanoemulsion containing low water soluble drug quercetin for lung cancer via aerosol delivery was prepared in this study. Formulation of quercetin nanoemulsion having the desirable criteria was 1.5 % of palm oil ester:ricinoleic acid (1:1 ratio), 1.5 % of lecithin, 1.5 % of Tween 80, 1.5 % of glycerol, and 93.95% of water. The formulatio...
Article
Full-text available
Microbial anti-cancer enzymes have been proven to be effective and economical agents for cancer treatment. Aeromonas veronii has been identified as a microorganism with the potential to produce L-glutaminase, an anticancer agent effective against acute lymphocytic leukaemia. In this study, a selective medium of Aeromonas veronii was used to culture...
Data
Complete genome of Aeromonas veronii strain TH0426. The complete genome of Aeromonas veronii TH0426 consists of 4923009 nucleotide base pairs. (PDF)
Article
Background: Nano-scale carbon systems are emerging alternatives in drug delivery and bioimaging applications of which they gradually replace the quantum dots characterized by toxic heavy metal content in the latter application. Objective: The work intended to use carbon nanospheres synthesized from biowaste Sago bark for cancer cell imaging appl...
Article
Background: Curcumin is a yellow polyphenolic chemopreventive agent isolated from the rhizomes of Curcuma longa. It is approved as Generally Regarded as Safe by US FDA. Nonetheless, its clinical success is limited due to its poor aqueous solubility, fast metabolism and short biological half-life attributes. Objective: Quercetin-decorated liposom...
Article
Full-text available
Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity, neu...
Article
Currently, traumatic brain injury (TBI) is the leading cause of death or of disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) make the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity, n...
Article
Nanotechnology receives a widespread application in semiconductor, manufacturing, and biotechnology industries [1]. Its biggest societal impact in pharmaceutical application is related to its use in design of nanomedicine with the aim to improve medical efficacy via resolving the poor drug bioavailability status. Pharmaceutical nanoparticles can be...
Chapter
There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalati...
Article
The experimental study presents a brief and comprehensive perspective on the methods of developing a Level A in vitro-in vivo correlation (IVIVC) for extended oral dosage forms of water-insoluble drug domperidone. The study also evaluates the validity and predictability of in vitro-in vivo correlation using the convolution technique by one-compartm...
Article
The aim of this study is to investigate artificial neural network (ANN) for prediction of drug contents. Hydroxypropylmethylcellulose and loratadine specifically were selected as model matrix polymer and drug. All 0, 5, 10, 20 and 40 mg drug loaded in hydroxypropylmethylcellulose films were conditioned at the relative humidity of 25, 50 and 75% eac...
Article
Full-text available
The applicability of visible spectrophotometry technique as a tool to determine the drug content of polymeric film for use as a transdermal drug delivery system was investigated. Hydroxypropylmethycellulose (HPMC) was selected as the matrix polymer and nifedipine as the model drug. Blank and nifedipine-loaded HPMC films were prepared using the solv...
Article
The applicability of microwave non-destructive testing (NDT) technique in characterization of matrix property of pharmaceutical films was investigated. Hydroxypropylmethylcellulose and loratadine were selected as model matrix polymer and drug, respectively. Both blank and drug loaded hydroxypropylmethylcellulose films were prepared using the solven...
Conference Paper
The present study investigated the potential of microwave nondestructive testing (NDT) technique for use in characterization of film for the application in transdermal drug delivery system. Hydroxypropyl methylcellulose and loratadine were selected as model matrix material and drug, respectively. Both blank and drug-loaded films were prepared using...
Article
Full-text available
With the increasing use of microwave radiation for communications and radar, it is necessary to know dielectric properties of various human tissues for evaluation of potential hazards to humans. Dielectric properties of human skin in vivo were measured in the frequency range of 20 - 38 GHz on 42 healthy volunteers (21 men and 21 women) in the palm...

Citations

... On the other hand, recent findings show that naturally extracted phytochemicals from plants have significant selective cytotoxicity for cancer cells while having minimal toxicity for normal cells. This may be a viable cancer treatment option (Devi et al., 2015;Roy et al., 2022). Therefore, in our study, 2500 natural compounds of plant origin were collected and selected for their inhibitory properties. ...
... Chitosan is a linear and cationic biopolymer derived from chitin after a deacetylation process and consisted of β (1-4) linked 2-acetamido-2-deoxy-β-D-glucopyranose and 2-amino-2-deoxy-β-D-glucopyranose structures, offering abundant amine (-NH 2 ) functional groups for better adsorption capacity and environmental adaptability [1,7,8]. On the other hand, alginate is an anionic polymer derived from seaweeds and is chemically structured of (1,4) linked β-D-mannuronic and α-ʟ-guluronic acid moieties, in which the hydroxyl (-OH) and carboxyl (-COOH) functional groups enhance the availability and stability in acidic environments, offering a potential application for encapsulation and controlled release of drugs [9][10][11]. ...
... [49] The low MDS (< 500 nm) inferred that the Tween 80/Span 80 mixture plus NaCl suitably yielded the roselle extract nano-sized droplets and could support good cell diffusion and increase diffusional mobility of active ingredients to all lung regions. [50,51] Another critical parameter is the PDI, where a low PDI value describes a unimodal, monodisperse droplet size population, and a PDI approaching 1 indicates a wide droplet size range. The study successfully produced a w/o NE in the moderate range of 0.61 ± 0.009, below the maximum 0.7 limit, for a NE with an acceptable uniformly distributed droplet size. ...
... Literature shows that an increase in the amount of surfactant can have many effects in our formulations, such as decreasing the particle size values and increasing the interfacial area, which leads to a decrease in surface tension. This effect is due to more emulsifiers covering the surfaces of the droplets, which are formed during the process known as homogenisation [42,43]. ...
... L-glutaminase isolated from Bacillus cereus and Alcaligenes faecalis induced growth inhibition of HepG2 cell lines of hepatocellular carcimona (Singh and Banik, 2013) and Hela cell lines of cervical cancer, further strengthening evidences supporting its anti-tumor potential (Dhankhar et al., 2020). L-glutaminase produced from Aeromonas veroni has been shown to have anti-cancerous potential against acute lymphocytic leukaemia (Jesuraj et al., 2017). ...
... Thus, they were used for fluorescence imaging of N2a and melanoma A-375 cells. Due to its safety, it is proposed that a higher concentration of the produced CQD fluorescence probes could be used to image samples that cannot be imaged using low probe concentrations [519]. ...
... Additional data from in vivo models support the anticancer potential of quercetin [50][51][52], with a noteworthy interest in reversion of chemoresistance [52,53] and in nanoencapsulation of this compound [52,54,55]. Taken altogether, the pleiotropic regulatory actions exerted by quercetin in endothelial cells would explain the potent antiangiogenic effect of this compound. ...
... Rouzi et al [30] developed PLGA NPs (poly (lactideco-glycolide) nanoparticles) loaded with cerebrolysin which interfered with BBB breakdown and edema formation in rats with concussive head injury(CHI). The brain-derived neurotrophic factor, BDNF of the neurotrophin family, when transported to the brain via PLGA NPs which were coated with surfactant poloxamer 188, improved neurological state and cognitive abilities of the trauma induced mice [31]. A measure that attempts to minimize secondary neuron degradation is the application of neuroprotective agents. ...
... Importantly, BDNF plays a crucial role in neuronal survival, differentiation and plasticity therefore making it an important therapeutic target for TBI as well as PD [163]. Intravenous administration of BDNF incorporated PLGA nanoparticles to mice subjected to weight drop TBI injury results in enhanced BDNF levels in the brain with subsequent improvement in cognitive and neurological outcome [164]. Unfortunately, the therapeutic potential of BDNF is hindered by its inability to cross the BBB and its short half-life when given systemically [165]. ...
... A commonly adopted way of measuring inhaler performances is the fine particle fraction (FPF), i.e. the ratio of API able to reach the deep airways to the total amount of API initially present in the aerosolized dose. The FPF is usually measured in-vitro, using cascade impactors with multiple filtering stages representing the subsequent branches of the human lungs [8]. ...