Wing-Yan Heidi Wan's research while affiliated with University of Leicester and other places

Publications (7)

Article
Full-text available
Background: Bronchial epithelial ciliary dysfunction is an important feature of asthma. We sought to determine the role in asthma of neutrophilic inflammation and NADPH oxidases in ciliary dysfunction. Methods: Bronchial epithelial ciliary function was assessed by video-microscopy in fresh ex vivo epithelial strips from asthmatics stratified by...
Article
Full-text available
The mast cell localization to airway smooth muscle (ASM) bundle in asthma is important in the development of disordered airway physiology. Thymic stromal lymphopoietin (TSLP) is expressed by airway structural cells. Whether it has a role in the crosstalk between these cells is uncertain. We sought to define TSLP expression in bronchial tissue acros...

Citations

... The enriched motif sequence displayed strong similarity to the consensus binding sequence (AGG TCA ) of Nr1d1 (Fig. 7c), suggesting a probable interaction of Nr1d1 with these genes. From our overall ChIP data, few of the genes having functions pertinent to specifically asthma and immunity have been listed (Fig. 7d) [64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81]. This association of Nr1d1 with other genes also partly explains the diverse physiological role of this receptor in metabolic, psychological, and immune disorders. ...
... TSLP production seem to be increased in chronic inflammatory diseases of the airways (asthma, CRS) and skin (atopic dermatitis) [5]. TSLP expression is significantly increased in asthma patients compared to healthy individuals in the inner and outer epithelial layers of airway biopsies [51,52,53,54,55,56,57,58] as well as in serum samples [59,60], sputum [61], exhaled breath condensate [62], and bronchoalveolar lavage fluid [57,63]. Moreover, TSLP expression has been shown to correlate with airway obstruction and disease severity in asthma patients [56,58,61,63,64]. ...