Wim J. R. Rietdijk's research while affiliated with Erasmus University Rotterdam and other places

... The current diagnosis of delirium is based on a diagnostic and statistical manual-5 (DSM-5) which has stated five key criteria for delirium diagnosis, (1) a disturbance in attention and awareness, (2) the disturbance develops over a short period from hours to days and represents a change from the patient's baseline attention and awareness, (3) with additional disturbance in cognition, (4) the disturbances are not explained by a pre-existing or other neurocognitive disorder, and (5) the disturbance is a direct physiological consequence of a wide variety of insults [1]. Based on the clinical psychomotor presentation, delirium is divided into three subtypes, such as hypoactive (unarousable, lethargy), hyperactive (agitated) and mixed subtype [2]. Evidence suggests that delirium is linked to several adverse short-and long-term outcomes, including a 2.2-fold increase in in-hospital mortality [3], a 2.5 time increase in health care costs [4], and a 12-fold increase in the risk of dementia [5][6][7]. ...

... However, the effect of bivalent vaccines on T cell immunity remains less understood and further studies are still required. A recent study by Tan et al. has shown that bivalent booster vaccination leads to a robust recall of memory T cell responses within the first 7 days after boost, that exhibit cross-reactivity against Omicron BA.1 and BA.5 variants regardless of the priming regime administered (234). ...

... The DOLPHIN trial evaluated MIDP (TDM coupled with dosing software) in patients treated with beta-lactams or ciprofloxacin. No benefit in terms of shortening the length of stay was observed, while target attainment in both MIDP and control groups was similar [139]. In a two-center Dutch trial, the adaptive dosing of four antibiotics including meropenem and ceftriaxone in septic patients did not lead to the better target attainment of these beta-lactams nor did it improve any clinical outcome [140]. ...

... A total of 400 participants, between 18 and 65 years old, will be recruited from healthcare workers across four university medical centers (UMC) in the Netherlands (i.e., Amsterdam UMC, Erasmus MC Rotterdam, UMC Groningen, and Leiden UMC). Participants will be predominantly, but not exclusively, recruited from previously published SWITCH (9,(18)(19)(20) and healthcare worker (HCW) studies (7,8,21). Extensive records on immune response to vaccinations against COVID-19 and breakthrough infections are available for participants from those two studies. ...

... The mutated receptor binding domain (RBD) of the spike (S) protein allows Omicron sub-lineages to spread more efficiently and enhances antibody evasion (5)(6)(7). Several studies have reported reduction in vaccineinduced neutralizing antibodies cross-reactive with Omicron sublineages (8,9), although T cell immunity remains largely intact (8,10,11). Severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) breakthrough infections can occur even after receiving a booster vaccination, or after acquiring infectioninduced immune responses. ...

... Significant heterogeneity exists in patients who received TTM [10,16,17]. The interventions and medications used in TTM vary greatly depending on the patient's condition, and there may be different complications after TTM that require additional treatments [6,10,16,18]. These variabilities may result in prolonged LOS for patients undergoing TTM. ...

... In addition, T-cell immunity was enhanced for up to 6 months after heterologous booster vaccination but not after homologous booster vaccination. These results are consistent with those of previous studies (11)(12)(13). Repeated exposure to the adenovirus vector in homologous booster vaccination might result in diminished immune responses. In this aspect, heterologous Ad26.COV2.S-mRNA vaccine booster vaccination would be more immunogenic than homologous booster vaccination in the Ad26.COV2.S-primed population. ...

... First, patients are obliged to do a 24-h ABPM to eliminate white coat hypertension. This blood pressure measuring method is the most reliable to establish true hypertension, but not patient friendly, as it often interferes with planned daily activities and the ability to sleep [37,38]. Therefore, this could lead to the exclusion of a specific group of patients that potentially do not have true resistant hypertension [39]. ...

... The pharmacokinetics appear to be linear up to 200 mg dose of spironolactone 8 . In a group of patients with resistant hypertension, sex as well as age, BMI and eGFR had no significant influence on concentration of spironolactone or canrenone and canrenone concentration was less influenced by time period between drug intake and sampling 13 . Because of a very short elimination half-life of the parent drug, serum concentrations of canrenone might be better predictors of patients' adherence, especially in an outpatient setting, in situations where time of ingestion is only estimated as reported by a patient. ...

... The immunogenicity and efficacy of the initial two-dose SARS-CoV-2 vaccination schedule and booster immunisations have been comprehensively studied in healthy adults (1)(2)(3)(4). Compared to healthy individuals, the immunogenicity of two doses of the AstraZeneca ChAdOx1 nCoV-19 and Pfizer BioNTech 162b2 SARS-CoV-2 vaccines are significantly diminished in individuals with primary (PID) and secondary immunodeficiencies (SID) (5). ...