William P. Santamore’s research while affiliated with Temple University and other places

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Publications (167)


Rural Residents Respond More Favorably Than Urban Residents to 12 Week Weight Loss Intervention
  • Conference Paper
  • Full-text available

May 2010

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21 Reads

Medicine and Science in Sports and Exercise

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William Santamore
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Cardiovascular Simulation Toolbox

July 2007

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321 Reads

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9 Citations

Cardiovascular Engineering An International Journal

A toolbox for Matlab Simulink (trademark of Mathworks corp. etc.) was developed to simulate various models of flow in the cardiovascular system and study effects of different pathological conditions. The toolbox was based on well-known analog lumped models of blood flow in vessels, the varying elastance heart model, blood flow through vessels, shunts, and valves as well as models of oxygen exchange at lungs and tissue. The toolbox is modular providing the basic building blocks of the cardiovascular system. Parameters for the individual components may be set by the user to adapt the component to the simulated system. Several examples are shown. This modeling system is described and is also available for downloading as an open source for free use. The authors see this as the basis for wide collaboration and standardization in modeling. A web site will be available for accepting contributions from other researchers and to create a free exchange.






Improving heart failure care by using a telemedicine system

February 2004

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7 Reads

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7 Citations

Conference proceedings: ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

Heart failure constitutes the most frequent and expensive hospital discharge diagnosis in the United States, costing annually over $10 billion. Optimal care requires an understanding of their illness, participating in clinical decisions, and frequent communication. Current surveillance is labor intensive and expensive. Follow-up is often inadequate, incomplete, and inconsistent. To address these problems, we developed an Internet-based telemedicine system, consisting of a secure server and database. Patients send or receive data to or from their care provider via the Internet. The system optimizes function and minimizes cost (all hardware is off the shelf and FDA approved). This paper describes our initial experience with this system. We are currently using this telemedicine system in a prospective, randomized clinical trial, comparing Class III or IV heart failure patients with standard care versus standard care plus telemedicine.


Endovascular Repair of the Abdominal Aortic Aneurysm

June 2003

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7 Reads

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2 Citations

Seminars in Cardiothoracic and Vascular Anesthesia

Since the early 1990s, endovascular surgery has provided another treatment option for the management of abdominal aortic aneurysms. Its shorter postoperative recovery time, absence of an abdominal incision, and avoidance of aortic cross-clamping gives endovascular abdominal aortic aneurysm repair its appeal. New vascular grafts are being developed that may expand the number of eligible candidates. This less-invasive form of abdominal aortic aneurysm repair still provides the anesthesiologist with several challenges. The procedure has been performed under general anesthesia, regional anesthesia, and local anesthesia with monitored anesthesia care. The potential benefits of one anesthetic type over another for endovascular abdominal aortic aneurysm repair have not yet been fully explored. Several intraoperative complications, including acute aortic rupture and misdeployment of the stent graft, can necessitate conversion to an open laparotomy. Endovascular repair in the short term compares favorably to open surgical repair with a reduction in morbidity, blood loss, and hospital stay. Still, endovascular abdominal aortic aneurysm repair is a relatively new corrective modality, and long-term controlled trials comparing it with open repair have not yet been reported. As more research into the technique is performed, new strategies for endovascular abdominal aortic aneurysm repair may further increase the options available to patients.


Citations (60)


... The second limitation is that our method cannot be used in patients with intra-cardiac shunts or severe mitral regurgitation. The dye dilution method we used cannot be applied in patients with intra-cardiac shunts or severe mitral regurgitation (31). The severe aortic regurgitation, however, did not vitiate the dye dilution determination of cardiac output (32). ...

Reference:

Cardiac Output Obtained from Test Bolus Injections as a Factor in Contrast Injection Rate Revision of Following Coronary CT Angiography
Determination of cardiac output by invasive methods
  • Citing Chapter
  • January 1993

... The femoral arteries should be at least 8-mm wide because the closed stent has a diameter of 7.5 millimeters, and other parameters have been evaluated, such as the amount of atheromatous plaques in the aneurism and in its distal end. The distal end of the aneurism has to be free of disease to guarantee good perfusion of the limbs, minimizing the migration of plaques 17,18 . If those criteria are fulfilled, the endovascular approach is done through the femoral artery, which is dissected in one side and punctured on the other. ...

Endovascular Repair of the Abdominal Aortic Aneurysm
  • Citing Article
  • June 2003

Seminars in Cardiothoracic and Vascular Anesthesia

... One of the leading causes of stress in plant species in the Caatinga is the high level of exposure to ultraviolet-B radiation, which is capable of slowing the growth of individuals and decreasing leaf area (ZHAO et al., 2020). This damage varies according to the degree of exposure of the leaves, with leaves closer to the ground being less susceptible to the negative effects of ultraviolet-B radiation due to shading (PARISI et al., 1998). Furthermore, leaves growing in the sun are known to exhibit marked morphological differences when compared to those in the shade. ...

A study of the total ultraviolet exposure to all the leaves for small-plant growth
  • Citing Article
  • August 1998

Journal of Photochemistry and Photobiology B Biology

... A sample of 111 university students was selected through convenience sampling from Cairo University and Tanta University, Egypt. The mean±SD of age was 19.88± 1.911 (range: [18][19][20][21][22][23][24][25][26][27][28][29]. Women represented 74.6% (n=94) of the sample. ...

Health Locus of Control Impacts Exercise Response to Telemedicine in Urban and Rural Underserved Populations: 2542
  • Citing Article
  • May 2008

Medicine and Science in Sports and Exercise

... Obviously this technique does not allow accurate determination of a desired recruitment level, tailored to individual patient response. George and colleagues demonstrated experimentally how variable the maximal recruitment amplitude can be between individual subjects [32]. Furthermore, significant differences in maximal pressure development during muscle contraction can occur with small increases in stimulation voltage which will certainly affect the degree of cardiac assist attained. ...

Voltage-dependent performance of skeletal muscle pouches: implications for cardiomyoplasty
  • Citing Article
  • September 1992

The Journal of Heart and Lung Transplantation

... The contributory factors are thought to be ischaemia of the muscle flap as a consequence of mobilisation and, possibly, sustained activity. A further consequence of fast-to-slow transformation is slower relaxation of the muscle wrap, which may interfere with the diastolic performance of the heart [15,17,18]. These fundamental concerns about the viability and performance of the LDM can be answered only if more is understood about the changes in nutrition and perfusion that occur within muscles in terms of conditioning and surgical mobilisation. ...

Dynamic cardiomyoplasty acutely impairs left ventricular diastolic function
  • Citing Article
  • December 1992

Journal of Thoracic and Cardiovascular Surgery

... Depression has also been linked to increased risk of cardiac thrombotic events via platelet reactivity and activation [83]. Upon activation, platelets secrete serotonin, which acts on platelet serotonin receptors to promote aggregation on the platelets [94,95] and causes vasoconstriction of arteries [12,96]. Depressed patients show an up-regulation of serotonin receptors on platelets, leading to increased density of platelet serotonin receptors [97,98] and changes in platelet reactivity and activation [99 -101]. ...

Platelet amplification of vasospasm
  • Citing Article
  • September 1992

American Journal of Physiology-Legacy Content

... Autoregulation of coronary circulation plays a major role in the control of myocardial blood flow (MBF). 1,2 It is well known that as coronary artery disease (CAD) progresses, resting flow does not initially change, but MBF (such as that achieved by injecting a vasodilator) decreases progressively. 3 In this setting, coronary autoregulation, reducing the resistance of distal perfusion beds, attempts to preserve adequate MBF and oxygen supply. 4 Only a coronary stenosis exceeding approximately 80% of luminal diameter induces significant reductions in resting MBF, while attenuation of hyperemic flow is detectable in the presence of coronary stenosis of about 45%. ...

Coronary autoregulation and optimal myocardial oxygen utilization
  • Citing Article
  • May 1992

Basic Research in Cardiology

... Myocardial oxygen consumption volume was measured according to the literature (Kal et al., 1999;Verma et al., 2010). Left ventricular function index was measured according to the literature (Amoore et al., 1992). All values are expressed as means ± SD. ...

Computer simulation of the effects of ventricular interdependence on indices of left ventricular systolic function
  • Citing Article
  • June 1992

Journal of Biomedical Engineering

... La utilización de antraciclinicos en el tratamiento de neoplasias humanas conlleva a un riesgo de cardiotoxicidad dosis dependiente que puede generar insuficiencia cardiaca (Singal 1998). La doxorrubicina se ha utilizado para inducir insuficiencia cardiaca en perros, ovejas y cabras (Chekanov, 1999;Tessier, 2003;Monnet, 1999;Cheng, 1992;Monnet, 2002). La doxorrubicina se puede administrar vía intravenosa o intracoronaria; esta última modalidad permite la administración de menores dosis evitando la toxicidad sistémica. ...

Effects of dynamic cardiomyoplasty on indices of left ventricular systolic and diastolic function in a canine model of chronic heart failure
  • Citing Article
  • July 1992

Journal of Thoracic and Cardiovascular Surgery