William D. James’s research while affiliated with University of Pennsylvania and other places

... další)(2). ...

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The Use of Topical JAK Inhibitors in Dermatology

... Sitosterolemia was described for the first time in 1974 by two sisters of Swiss and German origin [22]. It is caused by mutations of the genes encoding the structure and function of segments of the ABC cassette-more detailly in the ABCG5 (sterolin-1) and ABCG8 (sterolin-2) which are expressed in the liver and intestine [23]. Moreover, patients with phytosterolemia have high cholesterol synthesis due to HMG-CoA reductase upregulation. ...

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Phytosterols and the Digestive System: A Review Study from Insights into Their Potential Health Benefits and Safety

... La eritrodermia, también conocida como dermatitis exfoliativa generalizada o eritrodermia exfoliativa, es una patología poco frecuente, sin embargo, puede llegar a tener una mortalidad de hasta un 64%, por lo que requiere una identificación pronta y un manejo precoz (3). Algunos autores coinciden en que la eritrodermia no constituye una entidad definida, sino más bien un fenotipo clínico que puede presentarse en diversas patologías, tanto benignas como malignas, y encontrar su causa subyacente puede ser un verdadero reto médico (4). Mediante esta revisión bibliográfica actualizada, se pretende abordar generalidades de la eritrodermia en adultos, su presentación clínica clásica y algunos escenarios clínicos distintos que se han reportado en los últimos años, así como su manejo inicial, tratamiento y posibles complicaciones. ...

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Actualización y perlas clínicas del abordaje diagnóstico y terapéutico de la eritrodermia en adultos

... HUVS is a rare condition with a wide variety of associated manifestations, therefore its pathophysiology is not yet completely understood, although it is considered to be mediated by antigen-antibody complexes that are deposited on vascular lumina, resulting in complement activation through the classical pathway [1,2]. The association between HUVS and malignancies, particularly Hodgkin's and non-Hodgkin's lymphomas has been reported, yet the mechanism behind this association is not fully established, as to whether hypocomplementemic urticarial vasculitis is the cause or the consequence of the malignancy [3]. ...

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Hypocomplementemic urticarial vasculitis syndrome: a look beyond urticarial lesions

... Epidermotropism may occur. Angiocentric and angiodestruction are evident with extensive necrosis [8,9,13]. ...

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A Rare and Fatal Case of Cutaneous T-Cell Lymphoma (CTCL)

... Additionally, infections can spread from person to person, particularly among persons who have tinea capitis or pedis, or via the soil. The lesions typically present as centrifugally developing plaques that are erythematous, annular to serpiginous, with peripheral scale and center clearing [4] . According to Dr. Kent's homoeopathic tenet, "The microorganism is not the cause of disease. ...

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A case report: Evidence based homoeopathic treatment of diffuse superficial dermatophytosis

... A recent study of Bhattacharya et al. [34] reported 1.622 differentially expressed genes (DEGs) in the patient's SS lesional skin compared with HCs, revealing an enrichment for genes involving neutrophil-specific functions as well as neutrophil-related immune pathways and regulation of IL-1 production. As for the latter, IL-1β gene expression was substantially increased at the lesional skin level of a subset of SS patients, differently from what was observed for neutrophil marker genes such as MPO and arginases. ...

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Molecular Characteristics of Sweet Syndrome: A Systematic Review

... Phenotypes A and B, considered classic, include a higher prevalence of oligo-amenorrhea and clinical signs of hyperandrogenism, such as acne, consistent with the previous literature [29]. In studies conducted in Latin American countries, the most prevalent phenotypes in samples with a mean age similar to our study are A and B [31], presenting as overweight and with hypertriglyceridemia, in agreement with the findings of our research. ...

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Phenotypic Characterization of Patients with Polycystic Ovary Syndrome in a Population from the Ecuadorian Andes: A Cross-Sectional Study

... Professional societies, such as the Skin of Color Society, were created. The American Academy of Family Physicians, the Journal of American Academy of Dermatology, VisualDx, and others have all generated databases of images with clinical findings on skin of color for health professionals to access quickly and easily online [12][13][14]. Homegrown online databases have proliferated through social media, including the Instagram account Brown Skin Matters (@brownskinmatters) [15]. ...

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Skin Color Representation in Infectious Disease Textbooks

... Furthermore, our hospital conferences are presented via an 'unknowns' style presentation, which is a format that has been previously noted to be particularly effective in dermatology education. 5 It is also believed that physician-learners appreciate three specific qualities in clinical learning: case-based format, an aspect of problem-solving and practical learning points. 6 Our hospital conference presenters aim to incorporate these qualities in each case presentation, which may also increase the impact of this educational activity on audience satisfaction. ...

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Value of dermatology hospital conference as a continuing medical education‐accredited activity: A retrospective review