Wendy C Salmon's research while affiliated with University of North Carolina at Chapel Hill and other places
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Publications (3)
There is a need for a standardized, impartial calibration, and validation protocol on confocal spectral imaging (CSI) microscope systems. To achieve this goal, it is necessary to have testing tools to provide a reproducible way to evaluate instrument performance.
We evaluated fluorescent spectral beads (FocalCheck) from Molecular Probes/Invitrogen...
Despite the general importance of Ca(2+) signaling in signal transduction, and of goblet cell mucin hypersecretion in inflammatory pulmonary diseases, measurement of airway goblet cell intracellular Ca(2+) (Ca(i)(2+)) has not been reported. In this article, we describe the results of experiments measuring Ca(i)(2+) in primary cultures of human bron...
Live cell imaging methods were used to characterize goblet cells expressing a MUC5AC domain fused to enhanced green fluorescent protein that labels the granule lumen. Golgi complex and endosome/lysosome elements largely resided in the periphery of the granular mass. On the contrary, a tubular meshwork of endoplasmic reticulum (ER) was in close cont...
Citations
... Adhesion of epithelial cells to their neighbors and extracellular matrix is governed by adhesion complexes, and the integrin-interacting CALR is associated with the adhesion complex of the focal junctions (53). Thin calreticulin-containing tubules that encircle mucin granules of goblet cells are in close contact with endoplasmic reticulum tubules (54). The increased presence of the goblet cells and the significant upregulation of Calr in the probiotic group point to the key role of this protein in many of the cellular and immunoregulatory functions, which help to counter the inflammation. ...
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... The acute effects of SMM on mucin secretion likely were also mediated by intracellular Ca 21 mobilization resulting from activation of purinoceptors in HBE by nucleotides (11,38), which are contained in SMM (14). The concentration of ATP in SMM is approximately 1 mM, similar to the ATP levels observed in CF sputum (14). ...
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... This task, often underestimated and thus neglected, is necessary and is critical in Life Sciences to ensure reproducibility among laboratories and over time monitoring 1-3 . In the past, different groups have developed measurement protocols and published methods for a variety of wide-field and confocal microscope performance aspects [4][5][6][7] . The majority of these QC studies were recently reviewed 8,9 . ...
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