Wen-Qing Xie's research while affiliated with Central South University and other places

Publications (17)

Article
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Vast quantities of literature regarding the applications of exercise therapy for sarcopenia have been published. The main objective of this study is to determine the top 100 most-cited articles and analyze their bibliometric characteristics. This study reports a bibliometric analysis via a systematic search of the academic literature regarding the...
Article
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Sarcopenia is a geriatric syndrome that is characterized by a progressive and generalized skeletal muscle disorder and can be associated with many comorbidities, including obesity, diabetes, and fracture. Its definitions, given by the AWGS and EWGSOP, are widely used. Sarcopenia is measured by muscle strength, muscle quantity or mass and physical p...
Article
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Sarcopenia, an age-related disease characterized by loss of muscle strength and muscle mass, has attracted the attention of medical experts due to its severe morbidity, low living quality, high expenditure of health care, and mortality. Traditionally, persistent aerobic exercise (PAE) is considered as a valid way to attenuate muscular atrophy. Howe...
Article
Anterior cruciate ligament (ACL) injury is a common disease in orthopedics and mostly occurs as a noncontact injury in athletes. Patients' knee joint stability, which is crucial to their athletic ability, cannot be restored through conservative treatment; it can only be restored through ACLR (ACL reconstruction) surgery. The surgical techniques of...
Article
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Objective To investigate the role of autologous platelet-rich plasma (PRP) on the repair of meniscal white-white zone injury through promoting the proliferation of canine bone marrow-derived mesenchymal stem cells (BMSCs). Methods A total of 24 beagle dogs were selected to construct meniscal white-white zone injury models in both lateral knee join...
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Background To investigate the effect of complete rupture of the posterior cruciate ligament (PCL) on the biomechanics and histology of the medial collateral ligament (MCL). Materials and methods Seventy-two male rabbits were randomly divided into two groups: the ruptured group was treated with complete PCL amputation, while the intact group was on...
Article
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Sarcopenia is a progressive and widespread skeletal muscle disease that is related to an increased possibility of adverse consequences such as falls, fractures, physical disabilities and death, and its risk increases with age. With the deepening of the understanding of sarcopenia, the disease has become a major clinical disease of the elderly and a...
Article
Sphingosine 1-phosphate (S1P) regulates many cellular functions, such as differentiation, proliferation, migration, morphogenesis, cytoskeletal organization, adhesion, tight junction assembly, apoptosis and the localization of different cell types. S1P also controls the migration of osteoclast precursors between the blood and bone, and it keeps ost...
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Cryptococcus gattii (C. gattii) is a lethal pathogen that causes the majority of cryptococcosis cases in previously healthy individuals. This pathogen poses an increasing threat to global public health, but the mechanisms underlying the pathogenesis have remained to be fully elucidated. In the present study, the role of high-osmolarity glycerol (HO...
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Background: To investigated the effect of earthworm extract (EE) on deep second-degree burn wound healing process. Methods: A burn wound model was created on the mice's skin and was subject to different treatments: the control group received no treatment; the Jingwanhong (JWH: a well-established, widely used external ointment for treating burn w...
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Sarcopenic obesity (SO) refers to an obesity disease accompanied by low skeletal muscle quality, strength and/or function, which is more common in the elderly and seriously affects their quality of life and can lead to falls, unstable walking, balance disorders and fractures in the elderly. The increase in aging populations and the various health p...
Article
Cartilage is a relatively simple connective tissue that plays a variety of roles in the human body, including joint support and protection, load bearing of the intervertebral discs, joint lubrication, formation of the external structure of the ears and nose and support of the trachea. The maintenance of cartilage homeostasis is therefore crucial. C...
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Sarcopenia is a potential risk factor for weakness, disability and death in elderly individuals. Therefore, seeking effective methods to delay and treat sarcopenia and to improve the quality of life of elderly individuals is a trending topic in geriatrics. Caloric restriction (CR) is currently recognized as an effective means to extend the lifespan...
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Background. The subchondral bone parallels with the progression of osteoarthritis (OA). However, the biomechanical properties and histopathological changes of subchondral bone changes in the lumbar facet joint (LFJ) after long-term axial loading on the spine have not been explored. In this study, we aimed to investigate the subchondral bone histopa...
Article
Sarcopenia is a new geriatric syndrome that has become a heavily researched topic, and it is a potential risk factor for weakness, disability, and death in elderly people. As the world's population ages, the incidence of sarcopenia has also increased, which has resulted in a series of health problems and in large medical costs. Although there are g...
Article
Full-text available
Sarcopenia is often regarded as an early sign of weakness and is the core element of muscle weakness in elderly individuals. Sarcopenia is closely related to the reduction of exercise, and elderly individuals often suffer from decreased muscle mass and function due to a lack of exercise. At present, studies have confirmed that resistance and aerobi...
Article
Objective: In this study, a new type of reduction device for femoral shaft fractures was developed and designed. The reduction procedure was also standardized and is expected to be useful in clinical practice. Methods: A bone traction retractor that consisted of a special traction needle, a resistant sleeve, a crossbar and an arc-adjusting bar w...

Citations

... Some other attempts have investigated the additive effect of PRP over a previous surgical procedure [13,14,20]. Additionally, animal studies have demonstrated a beneficial effect on the controverted white/white zone when treated with PRP [46]. The additive effect of PRP has been evaluated on open meniscal repair for grade 2-3 horizontal meniscal injuries through a case-control study. ...
... The instrumental laxity using the AK-1000/2000 and the functional assessment using Lysholm score were also similar, suggesting comparability between the two techniques. Several biomechanical studies stated that DB PCL reconstruction better restore antero-posterior stability than SB techniques 9,12,24,25,[62][63][64][65] . A recent biomechanical study demonstrated that a DB PCL reconstruction could better restore knee stability across the full ROM, while SB leads to high graft tension during extension and laxity during flexion 66 www.nature.com/scientificreports/ ...
... Loss of motility and mobility is increasingly believed to be one of the most compelling indicators of poor health outcomes in older people [3,4]. Knowledge accumulated through decades of extensive research with many different animal and human models on skeletal muscle atrophy/deconditioning has provided us with a good understanding of the cellular processes implicated [5][6][7][8][9][10]. To identify other potential cellular mechanisms and improve understanding of those already discovered, is important to reveal the underlying causes of sarcopenia. ...
... The increased bone formation in global CTR-deficient mice was also observed in mice lacking the CTR specifically in osteoclasts, where CT limits the expression of Spns2, which encodes a transmembrane transporter protein facilitating the secretion of sphingosine-1-phosphate (S1P) from osteoclasts. In turn, S1P functions as a paracrine, osteoanabolic molecule, which enhances bone formation by binding to its S1P receptors expressed by osteoblasts [8][9][10][11]. Therefore, CT/CTR signaling functions as a physiologic inhibitor of bone formation and regulates the coupling of bone formation to resorption. ...
... The HOG pathway, one of the most important components of the MAPK cascade, regulates stress, sexual differentiation and virulence in C. neoformans through sensing external challenges, leading to protective responses against different stresses such as high osmolarity, ion concentration and temperature among others, ensuring cell integrity [32,[67][68][69]. HOG pathway seems to play a role in the negative regulation of the cryptococcal capsule. ...
... The imbalance of cartilage homeostasis is mainly the result of cartilage degeneration and inflammation (Ritter et al., 2013;Redondo et al., 2018;Xie et al., 2021). During OA, the initial stage of cartilage degeneration is manifested as superficial cartilage defect or fibrosis, followed by the formation of ulcers and cracks, and gradually expands to subchondral bone, making the cartilage thinner and thinner, leading to full-thickness cartilage defect (McCulloch et al., 2019; Chen et al., 2020). ...
... However, further studies should be conducted to fully understand the mechanisms by which senescent cells contribute to disease progression. Excessive evidence suggests that interventions targeting sarcopenia in association with ageinduced cellular senescence are extremely potential, which involve strategies regulating some molecules on the pathway of cellular senescence in sarcopenia, individual nutrition levels such as caloric restriction (Xie et al., 2020b), and individual physical levels including health education and exercise interventions (Xie et al., 2020a). This review aims to delineate the biological roles of cellular senescence in sarcopenia and their causal roles in mediating or delaying sarcopenia, which may activate therapeutic strategies for sarcopenia clinically, eventually extending health span in the elderly population. ...
... As motor neuron denervation outpaces reinervation, muscle atrophy and the aforementioned muscle fiber type remodeling occurs (Faitg et al. 2019). Studies have also pointed to the benefits of CR on muscle stem cells by decreasing inflammation and improving mitochondrial DNA repair in the mouse fed with CR (Xie et al. 2020). ...
... The multifactorial disorder of sarcopenic obesity is characterized by the loss of skeletal muscle mass, and by obesity [1]. Clinical studies have suggested a direct correlation between the increased intramuscular fat tissue and degenerative decline of skeletal muscle mass and strength [2,3]. The high level of inflammatory cytokines produced by adipose tissue was suggested to accelerate muscle catabolism [4][5][6][7]. ...