Wen-Chuan Chen’s research while affiliated with National Taiwan University and other places

... Synthesis of CAG CAG (Registry No. 84605-18-5; fig. 1 a) is a natural saponin of the Astragalus species found in small amounts [31,32] . CAG used in the present study was synthesized by acid hydrolysis of its glycoside astragaloside IV (Sigma-Aldrich, USA) as described previously [33] . The identity of CAG was determined and confirmed by 1 H-NMR, 13 C-NMR, and mass spectrometry. ...

Reference:

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

... In treatment of cancer [64] 1-O-Galloylpedunculagin Antioxidant activity [65,66] ( +)-cis-5,6-Dihydro-5-hydroxy4-methoxy-6-(2-phenylethyl)-2H-pyran-2-on A triterpenoid, pharmacological activity not know yet Ellagic acid It affects lipid metabolism by promoting cholesterol efflux and decreasing LDL uptake, while also possessing antioxidant, liver-protective, antisteatotic, anticholestatic, antifibrogenic, antihepatocarcinogenic, and antiviral activity [31] Ganoderic acid C Anti-inflammatory (inhibition of TNF α) activity [35,36,67] Ceanothic acid Anticancer and antimicrobial activity [68,69] Asiatic acid Antioxidant, anti-inflammatory and antihyperlipidemia activity [37,70] Azukisapogenol Antibacterial and antifungal activity [71] Liquiritic acid Atheroprotective, anti-inflammatory activity [72,73] (3beta,19alpha)-3,19,23,24-Tetrahydroxy-12-oleanen-28-oic acid A terpenoid showing similar chemical structure to arjunic acid and arjunin acid whose pharmacological activity is not known yet Considering two independent factors concentration of polymer PVPK30 (1,1.5, and 2%) and mixing speed (1000, 1500, and 2000) at three levels each, 9 batches were analyzed using design of experiment software version 6 (Fig. 6). The analysis employed a linear model (Table 3) to examine the correlation between polymer concentration and mixing speed regarding particle size of ACEN. ...

Reference:

Formulation and evaluation of nanobiotherapeutics of Terminalia arjuna through plant tissue culture for atherosclerosis

... revealed by resonances observed at δ C 165.6 (C-1''), 146.8 (C-3''), 122.9 (C-2''), 51.5 (OMe), and 18.0 (C-4'')[25]. The HMBC correlations observed from H-4 (δ H 5.55, dd, J = 3.2, 1.4 Hz) to C-1'' (δ C 165.6) and from the OMe (δ H 3.20, s) to C-7 (δ C 104.4) evidenced the linkage of the methoxy and the crotonyl groups at C-7 and C-4, respectively. ...

Reference:

Semisynthetic derivatives of massarilactone D with cytotoxic and nematicidal activities