Weizhe Su's research while affiliated with Cincinnati Children's Hospital Medical Center and other places

Publications (18)

Article
Dynamics in the sequence of count data is usually not only affected by the underlying hidden states to be detected, but also quite likely associated with other static or dynamically changing covariates. The multiple hypotheses testing procedure developed here takes these covariates into consideration by the Poisson regression model. Also, a hidden...
Preprint
Dynamics in the sequence of count data is usually not only affected by the underlying hidden states to be detected , but also quite likely associated with other static or dynamically changing covariates. The multiple hypotheses testing procedure developed here takes these covariates into consideration by the Poisson regression model. Also, a hidden...
Article
Full-text available
Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large‐scale proteomics. We applied the slow off‐rate modified aptamer scan (SOMAscan) to measure 1,305 proteins in serum sam...
Article
Full-text available
Background Data suggest an increased risk of thyroid dysfunction following iodine-based contrast material (IBCM) in children. Objective To estimate the prevalence of thyroid stimulating hormone (TSH) abnormalities following exposure to a single dose of intravenous IBCM during computed tomography (CT) in young children. Materials and methods Inpat...
Article
Full-text available
In autoimmune liver disease (AILD), including autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), and overlap syndrome of AIH and PSC (ASC), the presence of biliary injury portends a worse prognosis. We studied serum matrix metalloproteinase 7 (sMMP7) as a biomarker for pediatric sclerosing cholangitis (SC). We prospectively enrolled...
Article
Background Reports on the feasibility and effectiveness of translating proactive, antitumor necrosis factor (TNF) therapeutic drug monitoring (TDM) for inflammatory bowel disease into practice-wide quality improvement (QI) are lacking. We aimed to determine whether a TDM QI program improved outcomes at a large academic pediatric gastroenterology pr...
Article
Many longitudinal studies often require jointly modeling a biomarker and an event outcome, in order to provide more accurate inference and dynamic prediction of disease progression. Cystic fibrosis (CF) studies have illustrated the benefits of these models, primarily examining the joint evolution of lung-function decline and survival. We propose a...
Article
Background: A subset of patients with nonalcoholic steatohepatitis (NASH) respond to treatment with vitamin E. The characteristics of responders are not known. The objective of this study was to investigate the outcomes of vitamin E use in clinical practice and to determine factors associated with response to treatment. Methods: A pediatric coho...
Article
Background Acute kidney injury (AKI) remains a concern in hospitalized children undergoing CT with intravenous iodinated contrast material (ICM). Adult studies have shown frequencies of AKI after CT with intravenous ICM to be similar to propensity score-matched ICM-unexposed patient groups; similar data in pediatric patients are lacking. Purpose To...
Article
Multiple testing on dependent count data faces two basic modelling elements: the choice of distributions under the null and the non-null states and the modelling of the dependence structure across obser- vations. A Bayesian hidden Markov model is constructed for Pois- son count data to handle these two issues. The proposed Bayesian method is based...
Article
Multiple testing on dependent count data faces two basic modelling elements: the choice of distributions under the null and the non-null states and the modelling of the dependence structure across observations. A Bayesian hidden Markov model is constructed for Poisson count data to handle these two issues. The proposed Bayesian method is based on t...
Article
Purpose: The purpose of this study was to determine GER characteristics after Nissen fundoplication in children with aerodigestive disorders using pH-impedance technology. Methods: In this cross-sectional study, the institutional database of Cincinnati Children's Hospital Medical Center was reviewed to identify patients ages below 21 years who h...
Article
Full-text available
Purpose To define the relationship between compartmental abdominal fat stores, liver and pancreatic fat fractions, and type 2 diabetes mellitus (T2DM) in children with non-alcoholic fatty liver disease (NAFLD). Methods This was a retrospective study of patients with NAFLD who underwent abdominal MRI between August 2015 and July 2017. Using an axia...
Article
Full-text available
Purpose Magnetic resonance imaging (MRI) techniques are increasingly used to quantify and monitor liver tissue characteristics including fat fraction, stiffness, and liver volume. The purpose of this study was to assess the inter-relationships between multiple quantitative liver metrics and patient-specific factors in a large pediatric cohort with...
Article
Full-text available
Background Reticuloendothelial system MRI signal hypointensity is common in pediatric oncology patients with solid abdominal tumors. Objective To assess changes in liver, spleen and bone marrow T2-weighted MRI signal intensity over time and their relationship to blood transfusion history in children with solid abdominal tumors. Materials and method...
Article
Purpose To assess the diagnostic performance of magnetic resonance (MR) elastography-derived liver stiffness to detect liver fibrosis in a pediatric and young adult population with a spectrum of liver diseases. Materials and Methods This retrospective study included patients younger than 21 years of age who underwent MR elastography and liver biops...

Citations

... As the catalytic activity of MMPs is specific to collagen-like peptides, this may result in neoplastic metastases and fibrosis (26)(27)(28). MMPs have been also described as biomarkers in various liver diseases (29)(30)(31)(32)(33). Some research groups have proposed to recognize circulating serum MMPs as specified reliable biomarkers of active fibrosis (34)(35)(36)(37)(38)(39)(40). ...
... In 2019, Rath et al. [74] performed a prospective randomized controlled study on preterm infants undergoing peripherally inserted central catheter (PICC) placement who were exposed to intravenous IBCM -none of these children experienced hypothyroidism over the course of the 2-week follow-up, and the researchers found no statistical difference in thyroid function levels between exposed and control groups. A 2021 propensity-score matched comparative study by Gilligan et al. [75] showed similar prevalence of thyroid stimulating hormone abnormalities over a 3-month interval in hospitalized children ages 2 years and younger who received a single dose of intravenous IBCM compared to a similar group who underwent abdominal US exam without IBCM exposure. On independent literature review, the ACR statement concluded that (1) the risk of clinically significant hypothyroidism related to IBCM exposure is quite low for children younger than 3 months and minimal to absent in children 3 months and older, and (2) the decision to perform thyroid function testing for children exposed to IBCM should be made on an individual basis weighing each child's individual risk factors rather than making a universal recommendation for children through 3 years old [73]. ...
... External validation of population PK models in pediatric CD cohorts shows they can predict IFX trough levels within high accuracy [9,10]. Patients with IBD that had proactive IFX therapeutic drug monitoring (TDM) had better long-term outcomes [8,[11][12][13][14]. Thus, if IFX PK could be used to guide early IFX dose optimization and/or early changes in treatment, it may improve longterm outcomes in children with CD. ...
... When adjusted for age, body mass index, sex, race, and number of scans, the incidence of AKI was 2% versus 0.3% and 3.9% versus 1.6%, for these propensity-matched and paired models, respectively. The 1.4% rate of CA-AKI in this population is lower than previously reported in children (15,16), and while the rarity of AKI limits statistical power, this large sample is beneficial in reducing the risk for a type II error. Our findings support recommendations to weigh benefits against the very small but real risk of giving contrast media to children not undergoing dialysis (22,23). ...
... Different approaches have equally been explored in estimating parameters in the models, such as likelihood and quasi-likelihood. Some of these models are not robust in fitting count data that are over-dispersed and at the same time under-dispersed, such as the studies conducted by [20][21][22][23] . ...
... Previous studies have developed optimal and valid multiple testing procedures based on the hidden Markov model (Sun and Cai, 2009;Wang et al., 2019). Su and Wang (2020) proposed a Bayesian multiple hypotheses testing procedure for sequentially dependent count data (PHMM). Here we extended these studies by incorporating the covariate effects. ...
... Impedance pH monitoring also assesses for symptom correlation with reflux and can be used to evaluate the effectiveness of acid suppression. This may be useful to perform in certain situations, such as after anti-reflux surgery [13]. ...
... Conversely, negligible associations between fatty pancreas and metabolic profiles were found in the following studies: a meta-regression analysis of 9 studies with 1209 healthy individuals [24]; a randomized controlled trial of 137 adults with obesity but not diabetes and weight loss [90], and studies of 277 eligible participants with a long-term low-fat or Mediterranean/low-carbohydrate diet [91], 73 persons without diabetes [92], 158 children and adolescents with overweight/obesity [93], 8 monozygotic male twin pairs [94], 86 patients [95], pancreas sections of 72 Japanese nondiabetic (NDM) autopsy cases and 50 patients with diabetes and 49 age-and BMI-matched NDM patients who underwent pancreatic surgery [96], 1367 volunteers who underwent whole-body MRI and proton density fat fraction [97], 56 participants who underwent a frequent-sampling oral glucose tolerance test and MRI and 1H-MRS [98], and 97 women 3 to 16 months after pregnancy [99]. Theoretically, pancreatic fat accumulation may impair β-cell function via mechanisms including local free fatty acid release, triglyceride metabolite accumulation, oxidative stress, release of proinflammatory and vasoactive factors [100], apoptosis and subsequent fatty replacement [101], all of which induce β-cell injury. ...
... 2 As standard (label-guided) dosing with infliximab (IFX) monotherapy is associated with high rates of immunogenicity, 2 clinicians are left to decide between proactive therapeutic drug monitoring with IFX monotherapy, combination therapy (IFX and an immunomodulator), stratification of risk factors for immunogenicity with pharmacogenomics such as human leucocyte antigen (HLA) polymorphisms or a combination of these approaches to optimise efficacy and durability. [3][4][5] Prior data demonstrated that episodic IFX infusions were a significant risk for anti-TNF immunisation as well as infusion reactions. 6 Whether guided by proactive or reactive therapeutic drug monitoring, IFX dose optimisations during maintenance to achieve a targeted drug concentration has been associated with mucosal healing, improved drug durability and a reduction in hospitalisations. ...
... The performance of USe and TE for predicting fibrosis have been investigated sporadically in smaller pediatric cohorts, and cirrhosis reported to be accurately predicted, whereas distinction between other fibrosis stages were less accurate [9][10][11]. A high success rate of pediatric MRe has been reported [12] and a few studies, largely focusing on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, have reported on the relation between pediatric MRe results and histopathological fibrosis stage [13][14][15]. ...