WC Willett's research while affiliated with Dana-Farber Cancer Institute and other places

Publications (246)

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Background Although colorectal cancer (CRC) incidence in the US is declining overall, its incidence is increasing among those younger than 50 years of age. The reasons underlying the increasing trend are largely unknown, although behavioral changes, such as unhealthy diet and lifestyle factors, may be partially responsible. Design A prospective co...
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India has the second largest number of people with type 2 diabetes (T2D) globally. Epidemiological evidence indicates that consumption of white rice is positively associated with T2D risk, while intake of brown rice is inversely associated. Thus, we explored the effect of substituting brown rice for white rice on T2D risk factors among adults in ur...
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This abstract was withdrawn by the authors. Citation Format: Schoemaker MJ, Nichols HB, Wright LB, Brook MN, Jones ME, O'Brien KM, Adami H-O, Baglietto L, Bernstein L, Bertrand KA, Boutron-Ruault M-C, Chen Y, Connor AE, Dorronsoro M, Dossus L, Eliassen AH, Giles GG, Gram IT, Hankinson SE, Kaaks R, Key TJ, Kirsh VA, Kitahara CM, Koh W-P, Larsson SC,...
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Zhao and colleagues are addressing an important question about the efficacy of calcium and vitamin D on fracture risk reduction among community-dwelling adults age 50+. However, we are concerned about four aspects of their approach, which may affect the validity of their conclusions and implications for public health. Introduction: We discuss the...
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OBJECTIVE: To examine open-flame and/or high-temperature cooking (grilling/barbecuing, broiling,orroasting) and doneness preferences (rare, medium,orwell done) for red meat, chicken, and fish in relation to type 2 diabetes (T2D) risk among U.S. adults who consumed animal flesh regularly (≥2 servings/week). RESEARCH DESIGN AND METHODS: The prospecti...
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Introduction: The purpose of this study was to examine whether higher milk and dairy food consumption are associated with risk of hip fracture in older adults following a report of an increased risk for milk in Swedish women. Methods: In two US cohorts, 80,600 postmenopausal women and 43,306 men over 50 years of age were followed for up to 32 ye...
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Background and purpose: Few studies have examined the association between multivitamin use and the risk of stroke incidence and mortality, and the results remain inconclusive as to whether multivitamins are beneficial. Methods: The associations between multivitamin use and the risk of incident stroke and stroke mortality were prospectively exami...
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Introduction: We examined the association between intakes of total and specific sources of protein and hip fracture risk in postmenopausal women and men over 50 years of age. Our hypothesis was that a higher protein intake would not be associated with a higher risk of hip fractures. Methods: In this analysis, we followed 74,443 women in the Nurs...
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Abdominal obesity might increase fracture risk. We studied the prospective associations between waist circumference, waist-to-hip ratio, and hip fracture. The indicators of abdominal obesity were associated with increased hip fracture risk in women, but not in men. The increased risk was restricted to women with low physical activity. Introduction...
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In this study, we compare the extent to which seven available definitions of sarcopenia and two related definitions predict the rate of falling. Our results suggest that the definitions of Baumgartner and Cruz-Jentoft best predict the rate of falls among sarcopenic versus non-sarcopenic community-dwelling seniors. The purpose of the study is to com...
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Is sugar-sweetened beverage (SSB) consumption associated with age at menarche? More frequent SSB consumption was associated with earlier menarche in a population of US girls. SSB consumption is associated with metabolic changes that could potentially impact menarcheal timing, but direct associations with age at menarche have yet to be investigated....
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Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in pancreatic...
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Die hier kommentierte Veröffentlichung von Bolland und Kollegen hat mehrere Studien mit insgesamt sehr großen Teilnehmerzahlen zusammengefasst (Metaanalyse), in denen es um die Effekte einer Vitamin-D-Supplementierung auf verschiedene Endpunkte wie Herzinfarkt, Krebs, Hüftfrakturen und Mortalität ging. Die Autoren schlussfolgern, dass eine zusätzli...
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Background: Use of multivitamins may reduce the risk of colorectal adenoma, but the duration of use needed is unclear. Methods: We prospectively examined years of multivitamin use and risk of colorectal adenoma among 43 641 women who had a first endoscopy between 1991 and 2007 in the Nurses' Health Study II. Use of multivitamins was assessed throu...
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Background: Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer. Methods: We prospectively followed 75 680 women in the Nurses' Health Study, and examined the association between nut consumption and pancreatic cancer risk. Participants with a previous history of cancer were...
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Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry1 . The etiology2 and clinical behavior3 of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition4 . To identify...
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This chapter considers the various perspectives from which diet can be viewed and discusses the calculation of nutrient intakes from data on food consumption. Diets of human populations are extremely complex. They can be viewed in several ways, including as intake of constituent chemicals (such as essential nutrients, non-nutritive components of fo...
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Background/objectives: Obesity is associated with increased triglyceride levels. We examined whether overall obesity (body mass index (BMI)) and abdominal obesity (waist circumference (WC)) are independently associated with hypertriglyceridemia among the Korean population. Subjects/methods: A national sample of 5036 Koreans aged 19-64 was examin...
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Willett WC (Harvard School of Public Health, Boston, MA, USA). Dietary fats and coronary heart disease (Review). J Intern Med 2012; 272: 13–24. The relation of dietary fat to risk of coronary heart disease (CHD) has been studied extensively using many approaches, including controlled feeding studies with surrogate end-points such as plasma lipids,...
Data
Stratified analysis by selected characteristicsa
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169 Background: Given the importance of exposure between menarche and first childbirth in breast cancer risk, adolescent alcohol consumption may influence the risk of proliferative benign breast disease (BBD). Folate may modify the adverse effect of alcohol on breast cancer. Methods: We used data from 29,329 women in the Nurses’ Health Study II who...
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A relative decrease intake of n-3 to n-6 fatty acids has been implicated in the pathogenesis of depression. However, the associations between different sources of dietary n-3, n-6, and their ratio, and the risk of depression have not been prospectively studied. We prospectively studied 54,632 women who were 50 to 77 years of age and free from depre...
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Traditional hand-pounded rice has been replaced today with highly polished white rice in the Asian Indian diets. The study aimed to evaluate the nutritional as well as the sensory differences between the brown (0% polish) and the rice milled to different degrees of polish (2.3, 4.4 and 8.0%). Bapatla and Uma (red pigmented) varieties in both raw an...
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The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty years ago and, from the start, its far-sighted mission was to...
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Many patients avoid coffee, often on the advice of their physicians, because of concerns that it may increase the risk of heart disease. The current study is the largest and longest to date on the subject and combines data from the Health Professionals Follow-up Study (N=44,005) and the Nurses' Health Study (N=84,488). These studies began in 1986 a...
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Purpose: To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women. Design: Prospective cohort analysis. Participants: Seventy-six thousand three hundred eighteen women enrolled in the Nurses' Health Study (NHS). Methods: Women enrolled in the NHS from 1980 to 2000 were observed. Eligible...
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Background: Previous studies suggest possible associations between Western diet and acne. We examined data from the Nurses Health Study II to retrospectively evaluate whether intakes of dairy foods during high school were associated with physician-diagnosed severe teenage acne.
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Objectives We conducted a prospective analysis of the relation between breast size measured by self-reported bra cup size and breast cancer risk among a cohort of premenopausal women. Design Prospective cohort study Setting The Nurses' Health Study II is an ongoing, prospective cohort of 116,671 American female registered nurses. The study was in...
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Background: Epidemiologic studies have suggested a lower risk of coronary heart disease (CHD) at higher intakes of fruit, vegetables, and whole grain. Whether this association is due to antioxidant vitamins or some other factors remains unclear. Objective: We studied the relation between the intake of antioxidant vitamins and CHD risk. Design: A co...