WA Kaiser's research while affiliated with Medical University of Vienna and other places

Publications (719)

Article
Background/aim: Previous studies have indicated a highly significant correlation between invasive tumors and accompanying prepectoral edema (PE) in MR-mammography (MRM). The aim of the present study was to identify prognostic factors associated with PE as a diagnostic sign. Materials and methods: A total of 1,109 consecutive MRM exams were inclu...
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Purpose: To examine "constant lesion sharpness" as a morphological diagnostic sign in the differential diagnosis between benign and malignant lesions. Material and methods: This prospective study had institutional review board approval and was HIPAA compliant. In total 1014 consecutive patients were examined (mean age 55 years ± 13 years) and ev...
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Purpose: During clinical routine, we retrospectively discovered diagnostic criteria for "focal mastitis" in MR-Mammography (MRM). The aim of this study was to prospectively evaluate these criteria. Methods: 1975 consecutive patients were examined between 01/2010 and 12/2011. 29 patients fit the diagnostic criteria of focal mastitis. Results: I...
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Purpose: To demonstrate our primary findings, indicating perirenal edema as a first imaging sign towards primary hypertension. Methods: Out of 3190 consecutive MR-Mammography (MRM) examinations, 777 were performed with an additional body array coil. Incidentally, "perirenal edema" could be linked to a patient history of hypertension. We Therefor...
Article
We describe changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in tacrolimus associated encephalopathy. ADC was clearly increased and FA decreased in the involved regions. There was a strong local contrast-enhancing effect along the cortical surface. Repeat magnetic resonance imaging five days later showed an increase in...
Article
To evaluate by means of diffusion tensor magnetic resonance imaging (DTI) if changes in apparent diffusion coefficient (ADC) and diffusion tensor fraction anisotropy (FA) in unidentified bright objects (UBOs) and perilesional normal appearing brain regions of children with neurofibromatosis type 1 (NF1) can be observed. Ten children with NF1 underw...
Article
A variety of morphologic and kinetic signs of benign or malignant breast lesions contribute to a final diagnosis and differential diagnosis in magnetic resonance (MR) mammography (MRM). As a new sign, prepectoral edema (PE) in patients without any history of previous biopsy, operation, radiation, or chemotherapy was detected during routine breast M...
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To evaluate the accuracy of MRI of the breast (DCE-MRI) in a stand-alone setting with extended indications. According to the inclusion criteria, breast specialists were invited to refer patients to our institution for DCE-MRI. Depending on the MR findings, patients received either a follow-up or biopsy. Between 04/2006 and 12/2011 a consecutive tot...
Article
Purpose: 4D co-registration of X-ray- and MR-mammograms (XM and MM) is a new method of image fusion. The present study aims to evaluate its clinical feasibility, radiological accuracy, and potential clinical value. Methods: XM and MM of 25 patients were co-registered. Results were evaluated by a blinded reader. Results: Precision of the 4D co-...
Article
To evaluate the influence of lesion type (mass versus non-mass) and reader experience on the diagnostic performance of breast MRI (BMRI) in a non-screening setting.Materials and methodsConsecutive patients (mean age, 55 ± 12 years) with breast lesions that were verified by biopsy or surgery, and who had had BMRI as part of their diagnostic workup,...
Conference Paper
PURPOSE Morphological and kinetic signs of breast lesions contribute to diagnosis and differential diagnosis in MR-Mammography. Prepectoral edema in patients without any history of previous biopsy, operation, radiation or chemotherapy has been detected as a new diagnostic Sign during clinical routine. The purpose of this study was to evaluate the r...
Conference Paper
PURPOSE To evaluate the role of MR-Mammography (MRM) in patients with "BIRADS 4 cases", i.e. in patients in which conventional assessment (X-Ray or Ultrasound) would otherwise require biopsy. METHOD AND MATERIALS Breast specialists from all over the country were invited to send patients with "BIRADS- 4" findings in either X-Ray-Mammography or Ultr...
Article
In the past decade, there has been significant progress in the development of water soluble near-infrared fluorochromes for use in a wide range of imaging applications. Fluorochromes with high photo and thermal stability, sensitivity, adequate pharmacological properties and absorption/emission maxima within the near infrared window (650-900 nm) are...
Article
Arthritic joints are ideal disease entities to be assessed via optical imaging. Here, we investigated the selective accumulation behavior of two differently sized hemicyanine optical probes in arthritic joints and its modification during glucocorticoid therapy in the course of inflammation. The well-standardized preclinical antigen-induced arthriti...
Conference Paper
The KIT 3D USCT was tested in a pilot study on ten patients. The primary goals of the pilot study were to test the USCT device, the data acquisition protocols, the image reconstruction methods and the image fusion techniques in a clinical environment. The study was conducted successfully; the data acquisition could be carried out for all patients w...
Article
Ziele: Die MR-Mammografie (MRM) ist hochsensitiv fur die Detektion von Brustkrebs. Die semiquantitative Messung von Signalintensitats-Zeit-Kurven (SIK) stellt einen zentralen Teil des Untersuchungsprotokolls und der Bildanalyse dar. Zunehmend wird die Diffusionsbildgebung (DWI) in die MRM integriert, dieses Verfahren bietet quantitative Einblicke i...
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Full-text available
Optical imaging-based diagnostics identify malignancies based on molecular changes instead of morphological criteria in a non-invasive, irradiation free process. The aim of this study was to improve imaging efficiency by the development of a new Cholecystokinin-2-receptor targeted fluorescent peptide that matches the clinical needs regarding biodis...
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Objectives In the face of multiple available diagnostic criteria in MR-mammography (MRM), a practical algorithm for lesion classification is needed. Such an algorithm should be as simple as possible and include only important independent lesion features to differentiate benign from malignant lesions. This investigation aimed to develop a simple cla...
Article
Two echo planar imaging diffusion-weighted imaging (DWI) techniques [one breath hold (DWI(bh)), repetition time/echo time (TR/TE) 2100/62 ms; one at free breathing (DWI(fb)), TR/TE 2000/65 ms] were compared regarding diagnosis of focal liver lesions (FLLs) in 45 patients with suspected liver metastasis without prior treatment. Apparent diffusion co...
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The presence of multidrug resistance-associated protein (MRP) in cancer cells is known to be responsible for many therapeutic failures in current oncological treatments. Here, we show that the combination of different effectors like hyperthermia, iron oxide nanoparticles, and chemotherapeutics influences expression of MRP 1 and 3 in an adenocarcino...
Article
Purpose: To identify the potential of semi-quantitative enhancement-analysis in breast MRI to predict disease-related death in primary breast cancer patients. Materials and methods: The present study was planned and conducted according to international recommendations. All patients referred for pretherapeutic staging of primary breast cancer dur...
Article
Due to their different physical origin, X-ray mammography and Magnetic Resonance Imaging (MRI) provide complementary diagnostic information. However, the correlation of their images is challenging due to differences in dimensionality, patient positioning and compression state of the breast. Our automated registration takes over part of the correlat...
Article
PURPOSE In an agreement between one of the major german insurance companies and our university hospital administration, patients with unclear densities, in which biopsy would have been otherwise the necessary next step without MR-Mammography (MRM), were included. Patients were openly referable through external physicians. The subjects of this study...
Conference Paper
We have developed a three-dimensional ultrasound computer tomography system (3D USCT) for early breast cancer diagnosis. The method gives reproducible volume images of the female breast in 3D. The optimized aperture and transducer array systems show at the used low ultrasound frequency of 2.5 MHz a very high image quality. In contrast to other meth...
Article
Multimodal imaging (e.g. MRI and optical imaging) with targeted nanoparticle based magneto-optical probes allows for detection of a broad range of molecular-cellular targets through their modular design. Here, we propose the construction multimodal probes addressing mVCAM-1 expression on endothelial cells as response to inflammatory factors. Target...
Article
1. Background Despite significant advances in the therapeutic options, breast cancer remains the most frequent and most deadly malignant neoplasm in women [1]. Probably more than in any other oncologic setting, medical imaging plays a central part in the work up of every single patient diagnosed with this disease. This covers not only pretherapeuti...
Article
Many different nanostructures have been developed for biomedical applications to date. Among them, iron oxide nanoparticles have been very prominent in MRI in diagnostic radiology. Nowadays, nanoparticle-based therapeutic applications have gained increased interest, leading to the development of a great variety of different and, in parts, sophistic...
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Accurate staging of primary breast cancer is essential for the therapeutic approach. Modern whole-body MR scanners would allow local and distant staging during a single examination. Accordingly, we designed a dedicated protocol for this purpose and prospectively evaluated the diagnostic accuracy. 65 consecutive breast cancer patients underwent pre-...
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To evaluate the diagnostic accuracy of qualitative descriptors alone and in combination for the classification of focal liver lesions (FLLs) suspicious for metastasis in gadolinium-EOB-DTPA-enhanced liver MR imaging. Consecutive patients with clinically suspected liver metastases were eligible for this retrospective investigation. 50 patients met t...
Article
Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced liver MRI is widely used for detection and differentiation of focal liver lesions. Diffusion weighted imaging (DWI) including apparent diffusion coefficient (ADC) measurements is increasingly utilised as a fast and, with limitations, quantitative method for liver les...
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Full-text available
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is able to detect breast cancer with high sensitivity. Furthermore, this method provides functional information on tissue composition and vascularization. This study aims to identify the potential of DCE-MRI to predict distant metastasis in breast cancer patients using computer assisted...
Chapter
Ziele: In Zeiten begrenzter Personalressourcen ist E-learning attraktiv, da es ein effektives, individuelles Lernen bei gleichzeitig enger Supervision der Lernenden (Studenten oder Assistenzärzte) und flexiblem Zeitmanagement des Lehrenden ermöglicht. Daher haben wir eine E-learning Software samt E-Curriculum zum mehrstufigen, strukturierten E...
Chapter
Ziele: Die Registrierung von „Konventionellen“ und „Magnetresonanz Mammographien“ (KM, MRM) ermöglicht es, Befunde aus zwei komplementären Verfahren exakt zu korrelieren. Bislang werden hierfür nur anatomische Daten verwandt; dynamische MRM-Anreicherungscharakteristika werden nicht berücksichtigt. Wir haben eine 4D-Registrierung entwickelt, welche...
Chapter
Ziele: Das Matching konventioneller und MR-Mammographien (KM und MRM) würde es erlauben, diese komplementären Verfahren in eine einzige diagnostische Untersuchung zu kombinieren. Dies wäre von potenziellem Nutzen für die diagnostische Genauigkeit und den radiologischen Workflow. Daher haben wir hierfür ein automatisches Matchingverfahren entwickel...
Article
Background: Tufted angioma represents a benign vascular lesion of the skin. The knowledge of this distinctive entity is important in distinction of clinically more aggressive and malignant neoplasms respectively. Case report. We report a 8-months-old girl who developed a deep seated tufted haemangioma on her right forearm. Sonography and MRI showed...
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Full-text available
In recent years, much progress has been made in analyzing the molecular origin of many diseases in vivo. For most applications, attention has been devoted to the detection of single molecules only. In this study, we present a proof of concept for the straightforward monitoring of interactions between different molecules via Förster resonance energy...
Article
Purpose: Neurological and smelling disorders (e.g. Alzheimer's disease, sinonasal disease) negatively affect the microstructural integrity of the olfactory bulb's (OB) cortical layers. Recovery processes depend on active restoration of this microstructural integrity enabled by neuroneogenesis in the OB. The aim of this study was to evaluate lamina...
Article
Choline (Cho) signal identification and quantification in (1)H MRS are used in breast cancer diagnosis. However, an influence of the gadolinium-based contrast agent on the Cho amplitude has been reported experimentally. This study aims to identify the impact of gadolinium-based contrast agents on Cho detection and quantification in postcontrast bre...
Article
Current procedures for the identification and characterization of microorganisms are based on complex and time-consuming protocols. Here, we hypothesize that the distinct cellular composition of microorganisms could be identified by dielectric spectroscopy. Gram-positive and Gram-negative bacterial strain permittivity measurement was performed usin...
Conference Paper
PURPOSE As little data of 3 Tesla MR imaging of the internal craniocervical ligament imaging is yet available and the involvement of the internal craniocervical ligaments in whiplash-injury associated disorders is still discussed controversely, the purpose of this study was to assess the morphology and visibility of these ligamentous structures wit...
Conference Paper
PURPOSE As only little data of 3 Tesla MR imaging of the internal craniocervical ligament imaging is yet available and the involvement of the internal craniocervical ligaments in whiplash-injury associated disorders is discussed controversely, the purpose of this study was to assess the morphology and visibility of these ligamentous structures with...
Conference Paper
PURPOSE Presence of axillary lymph node metastases (LNM) is amongst the most powerful prognostic factors in breast cancer. Classification of LNM as „present“or „absent“ is a common approach in clinical practice. Yet, recent publications recommend using the quantity of metastatic lymph nodes as a more accurate predictor for survival outcome. However...
Conference Paper
PURPOSE Dynamic contrast enhanced Magnetic Resonance Imaging (DCE-MRI) enables the assessment of changes in tumor vasculature after neoadjuvant chemotherapy (NEO) of breast cancer. Due to a recent metaanalysis, human reader sensitivity to predict complete response (CR) is limited. Computer Assisted Diagnosis (CAD) is widely used to increase sensiti...
Conference Paper
PURPOSE There is increasing data, suggesting that breast MRI provides not only diagnostic but also prognostic information. Nevertheless, the potential incremental value of this breast imaging technique compared to classical prognostic factors has not been evaluated, yet. Accordingly, this study aims to systematically investigate the potential of cl...