W Meyer’s research while affiliated with Hochschule Hannover and other places

... In view of current literature demonstrating the effect of MSCs on a broad range of diseases, there is considerable evidence indicating some preferences in the choice of the most suitable species for a study of interest (Fig. 2). For example, pigs have been extensively used to study the wound healing process due to the numerous similarities of pig skin to human skin, such as relatively thick epidermis, dense elastic fibers in the dermis, similar biochemical structure of collagen, sparse hair, and epidermal turnover of approximately 30 days [113,114]. Importantly, pig wound models have been regarded as the most appropriate to model cutaneous wound healing in humans (reviewed in [115]). In a review, Sullivan et al. [116] provided comparison of the data that documents wound therapies in different animal models and found that pig models were 78% consistent with human studies; this record exceeded that of other species, which overlapped with human data by only 53%. ...

Reference:

Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science

... These characteristics make large animals particularly useful for flap research. Among them, pigs are the most commonly utilized model because of the high similarity between pig and human skin [14][15][16]. Both the vascular anatomy and surgical procedure of flap models have been comprehensively explored and have shown great similarities to their human counterparts [17]. ...

Reference:

The vascular anatomy and harvesting of the medial femoral condyle flap in pigs

... While other studies have investigated the characteristics of porcine skin, these studies have focused on specific aspects such as the enzymatic properties and collagen fiber alignment or have been limited to analysis of skin from a specific location. 9,11,34,[61][62][63][64][65] This study shows that significant regional differences in skin histology exist between various body sites and suggests that consideration regarding anatomic location should be made when selecting porcine skin as an analogue for human skin either for in vivo studies or in the development of biologic scaffolds derived from decellularized dermis. ...

Reference:

Regional Variations in the Histology of Porcine Skin

... All fibers and fiber bundles are interwoven by smaller fibers from one bundle to another, forming 3D networks. In typical skin tissues from the back and lateral body wall of the wild boar, collagen fiber bundles are often relatively thick and long and penetrate the subcutis (Meyer et al., 1982). Biological crosslinking between collagen fibrils stabilizes the collagen network and improves the strength of skin (Wells et al., 2013). ...

Reference:

Collagen processing with mesoscale aggregates as templates and building blocks