W. Grundler’s research while affiliated with Stuttgart University of Applied Sciences and other places

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Publications (15)


Mechanism of electromagnetic interaction of cellular systems
  • Literature Review

January 1993

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80 Reads

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175 Citations

The Science of Nature

W Grundler

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F Kaiser

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The question of how electromagnetic fields--static or low to high frequency--interact with biological systems is of great interest. The current discussion among biologists, chemists, and physicists emphasizes aspects of experimental verification and of defining microscopic and macroscopic mechanisms. Both aspects are reviewed here. We emphasize that in certain situations nonthermal interactions of electromagnetic fields occur with cellular systems.





Resonant Cellular Effects of Low Intensity Microwaves

January 1988

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38 Reads

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46 Citations

Biological effects of low intensity microwaves have been the subject of a great number of studies and many different reactions were reported ranging from molecular to animal level. The acceptance level is low, however, due to difficulties both in reproducing the effects by others and in demonstrating their real athermal nature. In some cases great efforts were put into repeating athermal experiments, without clear results. In these studies the interpretation of data assumes a statistical behaviour which possibly is not adequate to the biological system (Kaiser 1984). These problems will probably remain as long as the mechanisms of these subtle effects are unknown. It seems worth thinking of new concepts for experimental investigations in athermal bioelectromagnetics. To focus on fundamental mechanisms, experiments must be oriented strongly by theoretical concepts rather than by simply investigating, for instance, biological reactions induced by a fixed frequency.



Nonthermal Resonant Action of Millimeter Microwaves on Yeast Growth

January 1984

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13 Reads

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2 Citations

This talk describes experimental results which prove that microwaves can interact with biological cells in a nonthermal manner. It is shown that observed microwave effects differ strongly from those obtained by applying other Types of energy instead of microwaves at equivalent rates. The two most intriguing aspects of the interaction are that there exists an intensity threshold above which the effects appear, and that the effects are different for minute changes of microwave frequency. A step-like intensity dependence is paired with a resonant frequency dependence. The latter is described by a quality factor of about 104. The effects are as yet unexplained. The locus of interaction is not known. It is however remarkable that both an intensity threshold and a resonant behaviour are predicted in H. Frohlich’s hypotheses of coherent excitations in biology.


Sharp Resonances in Yeast Growth Prove Nonthermal Sensitivity to Microwaves

September 1983

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56 Reads

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147 Citations

Physical Review Letters

Microwaves near 42 GHz are found to influence the growth of Saccharomyces cerevisiae. The growth is measured photometrically in stirred aqueous culture. The microwave effect occurs and saturates above a threshold intensity < 10 mW/cm2, excluding any explanation based on microwave heating. A surprisingly strong frequency dependence is observed, with resonances as narrow as 8 MHz. These results confirm the existence of a nonthermal resonant microwave sensitivity in biology; they suggest yet unknown tuned systems triggering yet unknown biological actions.


Biological Effects of RF and MW Energy at Molecular and Cellular Level

January 1983

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18 Reads

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7 Citations

Primary interaction between absorbed RF and MW energy and biological material takes place at the molecular and cellular levels. Biomolecules or assemblies of molecules are thought to be influenced by these external fields. These disturbances can be studied, for instance as effects on metabolism or regulation. The cell, as the smallest self reproducing unit, offers a great possibility for studying RF and MW effects as most biological mechanisms are involved in growth and cell division. Therefore, experimental studies on this level are both possible and necessary for investigating the basic mechanisms of biological interaction of ELM-wave energy.



Citations (10)


... There were several early reviews of MMW studies beginning in the 1980s that examined subjects like theoretical modeling and possible interaction mechanisms [289][290][291][292][293]. Pakhomov et al. [269] also published an extensive review of MMW research, examining over 300 former Soviet Union Block studies, which had focused primarily on therapeutic/clinical applications of MMWs, as well as about 50 studies from other countries that had focused on public health effects. ...

Reference:

Effects of non-ionizing electromagnetic fields on flora and fauna, part 1. Rising ambient EMF levels in the environment
Biological Effects of RF and MW Energy at Molecular and Cellular Level
  • Citing Chapter
  • January 1983

... Choice of the frequencies was based on the following representations: it was shown that the irradiation with 41.8-42.2 GHz frequencies has a pronounced effect on the biological objects [30,31]: 51.8 GHz frequency is considered to be resonant for water [29]. The chosen time of the irradiation, in turn, was based on our early obtained data, indicating that an hour irradiation exerts the most significantly pronounced effect at the aforementioned frequencies [20,29]. ...

Experimental evidence for coherent excitations correlated with cell growth
  • Citing Article
  • January 1992

... In the case of frequency resonance, the EMF energy is effectively perceived by the object and may lead to restructuring of its structure and properties. It was described both theoretical and experimental determination of resonant frequencies (from molecules to the whole organism), which is the basis for establishing the primary receptors of biological action of weak EMFs [83][84][85][86]. ...

Nonthermal Resonant Effects of 42 GHz Microwaves on the Growth of Yeast Cultures
  • Citing Chapter
  • January 1983

... Some of the animal models with potential significance to wildlife cited in Pakhomov et al. [269] included: yeast: Saccharomyces cerevisiae, [294][295][296][297][298]; Candida albicans [299]; barley seeds [300]; protozoans Spirostum spp. [301]; blue-green algae Spirulina platensisby [302]; midge Acricotopus lucidus [303]; Escherichia coli [304]; rats [305]; frog/nerve cells [306][307][308][309][310]; antibiotic resistance to Staphylococcus aureus [311] and others. ...

Resonant Cellular Effects of Low Intensity Microwaves
  • Citing Chapter
  • January 1988

... Moreover, the practice of irradiating patients with low power density millimetre wave beams as part of the treatment for a variety of medical conditions, ranging from duodenal and peptic ulcers to cancers, has become widespread in the former Soviet Union (Pakhomov et al 1998). However, the mechanisms that may be involved remain the subject of conjecture and published experimental proof that such effects exist at all is far from conclusive (Frohlich 1980, Grundler and Kaiser 1992, Belyaev et al 1993a, Blank 1993, Marani and Feirabend 1993, Belyaev et al 1994, Belyaev et al 1996, Osepchuk and Petersen 1996, Gos et al 1997, Kwee and Rasmark 1998, S Hadjiloucas et al Preece et al 2000). As with any new technology, there may be public concern over possible health effects, especially as terahertz radiation seems to have acquired the rather evocative title 'T-rays'. ...

Intensiy- and frequency-dependent effects of microwaves on cell growth rates
  • Citing Article
  • June 1992

Bioelectrochemistry and Bioenergetics

... In fact, as explained, the differences are several orders of magnitude greater in the case of environmental EMF exposures. This result is in agreement with experimental studies showing that the vast majority of recorded EMF bioeffects are non-thermal (Carpenter and Livstone 1968;Adey 1981;Gründler 1992;Kwee and Raskmark 1998;Velizarov et al. 1999;Panagopoulos et al. 2007a;2007b;2010;and reviews Walleczek 1992;Goodman et al. 1995;Creasey and Goldberg 2001;Belyaev 2005 Wust et al. 2021). Moreover, the above result is in agreement with the suggested mechanism of action of EMFs on cells (Panagopoulos et al. 2000;2015;2020;. ...

Intensity and frequency-dependent effects of microwaves on cell growth rates
  • Citing Article
  • June 1992

Journal of Electroanalytical Chemistry

... Herbert Froehlich (1968) postulated that quantum coherence is an inherent property of living cells, which utilize it for long-range interaction purposes such as synchronization of cell division processes. However, only scant experimental evidence exists to support these claims (Webb 1980;Grundler & Keilman, 1983). Attention has recently been brought to the quantum mechanical nature of photosynthesis (Arndt, Juffman, & Vendral, 2009;van Grondelle & Novoderezhkin, 2006) where reaction centers capture individual photons and transfer exciton energy by tunneling and thereby avoiding decoherence at room temperatures. ...

Sharp Resonances in Yeast Growth Prove Nonthermal Sensitivity to Microwaves
  • Citing Article
  • September 1983

Physical Review Letters

... Several investigators have proposed that mm-waves can produce resonance-type responses in macromolecules, although the experimental data on which these theories are based is often weak. For example, in the late 1970s, Grundler et al. [21] reported that exposure to mm-waves caused sharp frequency-dependent effects in the growth rate of yeast; however, this effect could not subsequently be confirmed by other investigators and presumably is an artifact [22]. More recently, Belyaev et al. [23] reported resonance-like effects of mm-waves on bacterial cells, but this has not been independently confirmed. ...

Resonant growth rate response of yeast cells irradiated by weak microwaves
  • Citing Article
  • September 1977

Physics Letters A

... This large gap in the literature on in vitro studies in bioelectromagnetics prevents researchers from determining the importance of the different exposure parameters in their experimental developments and, therefore, the search for mechanisms of action that may help to elucidate the results found in their research. Many hypotheses have been put forward [26,[46][47][48][49][50][51][52][53][54], but few conclusions have been drawn from the research articles. ...

Mechanism of electromagnetic interaction of cellular systems
  • Citing Article
  • January 1993

The Science of Nature

... Carew et al., (2014a), (2014b) observed a significant decrease in the native grape yeasts population when using high-power microwaves (1150 W) in grape crushing before fermentation, thus attaining a controlling effect. On starter cultures, MW could exert a beneficial effect if used throughout maceration by increasing the fermentation yield and reducing the lag phase of some yeasts (Carew et al., 2014a(Carew et al., , 2014b, probably as a result of an effect on the growth kinetics of Saccharomyces cerevisiae and related yeasts (Grundler et al., 1982). These effects are probably the result of power/intensity of MW treatments, as low-power treatment could improve growth kinetics, while highintensity treatment could determine yeasts' death (Pinto et al., 2020). ...

Resonant-like dependence of yeast growth rate on microwave frequencies
  • Citing Article
  • Full-text available
  • April 1982

The British journal of cancer. Supplement