Vladimir Zalkind's research while affiliated with Hebrew University of Jerusalem and other places

Publications (3)

Article
General anesthetic agents induce loss of consciousness coupled with suppression of movement, analgesia and amnesia. Although these diverse functions are mediated by neural structures located in wide-ranging parts of the neuraxis, anesthesia can be induced rapidly and reversibly by bilateral microinjection of minute quantities of GABAA -R agonists a...
Article
Microinjection of pentobarbital into a restricted region of rat brainstem, the mesopontine tegmental anesthesia area (MPTA), induces a reversible anesthesia-like state characterized by loss of the righting reflex, atonia, antinociception, and loss of consciousness as assessed by electroencephalogram synchronization. We examined cerebral activity du...
Article
Concussion, asphyxia, and systemically administered general anesthetics all induce reversible depression of the organism's response to noxious stimuli as one of the elements of loss of consciousness. This is so even for barbiturate anesthetics, which have only modest analgesic efficacy at subanesthetic doses. Little is known about the neural circui...

Citations

... The parameter measured is postponement of emergence, rather than anesthetic induction per se. However, we have previously documented in rats that pro-anesthetic effects, specifically frank induction of anesthesia, is observed when GABAergic drugs are delivered to the MPTA while the animal is in the awake state (Devor and Zalkind 2001;Devor et al. 2016;Avigdor et al. 2021). Sequentially altering experimental parameters from one protocol to the next improved our ability to detect significant bonus times. ...
... There are also several reports suggesting the importance of sevoflurane action via the MHb, such as the report that nitric oxide (NO) signaling via guanylyl cyclase in the MHb facilitates the effects of sevoflurane [31]. As for the LHb, it is important for propofol-induced sedation [13], and various other sedatives (ketamine, ethanol, pentobarbital, muscimol and chloral hydrate) have been reported to increase c-Fos expression in the LHb [1,29]. The LHb consists mainly of glutamatergic neurons, with the medial part projecting to the raphe nucleus and the lateral part to the reticular formation [2,13,15]. ...
... Direct electrical stimulation at appropriate subcortical locations in humans and animals readily evokes pain experience and pain behavior, subcortical seizure activity can be painful, appropriate subcortical regions are activated in functional imaging and pathway lesions can relieve pain [31,56,95]. What is more, localized microinjection of minute quantities of opiates into the brainstem PAG yields selective whole-body analgesia and microinjecting GABAergic anesthetics into the brainstem MPTA (mesopontine tegmental anesthesia area) yields LOC including insensitivity to noxious stimuli [96][97][98][99]. Most telling of all, localized lesions in the dorsal mesopontine tegmentum readily induce LOC in animals and humans, and lesions limited to the MPTA render animals relatively insensitive to otherwise clinically effective doses of anaesthetics delivered systemically [90,91,[100][101][102]. ...